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Q54BW5 (DUT_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:dut
ORF Names:DDB_G0293374
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the dUTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000327582

Regions

Region97 – 993Substrate binding By similarity
Region111 – 1144Substrate binding By similarity
Region170 – 1712Substrate binding By similarity
Compositional bias21 – 266Poly-Asn

Sites

Binding site1221Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1651Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54BW5 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 46187E1F460A533F

FASTA17919,532
        10         20         30         40         50         60 
MPIEQKYFSL FSNLFKRLTT NNNNNNYLKM APPNFETFKV KKLSDKAIIP QRGSKGAAGY 

        70         80         90        100        110        120 
DLSSAHELVV PAHGKALAMT DLQIAIPDGT YGRIAPRSGL AWKNFIDCGA GVIDSDYRGN 

       130        140        150        160        170 
VGVVLFNHSD VDFKVAVGDR VAQLIFERIV TPEPLEVDEI DETQRGAGGF GSTGVKVQN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000204 Genomic DNA. Translation: EAL60754.1.
RefSeqXP_629169.1. XM_629167.1.

3D structure databases

ProteinModelPortalQ54BW5.
SMRQ54BW5. Positions 38-162.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0230111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0230111; DDB0230111; DDB_G0293374.
GeneID8629190.
KEGGddi:DDB_G0293374.

Organism-specific databases

dictyBaseDDB_G0293374. dut.

Phylogenomic databases

eggNOGCOG0756.
OMAAVKHGIQ.
PhylomeDBQ54BW5.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Other

PROQ54BW5.

Entry information

Entry nameDUT_DICDI
AccessionPrimary (citable) accession number: Q54BW5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase