Reviewed, UniProtKB/Swiss-Prot Q54BT5 (ABCA3_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter A family member 3
Alternative name(s):
    ABC transporter ABCA.3

Gene names

Name:	abcA3
ORF Names:	DDB_G0293436

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1702 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1702	1702	ABC transporter A family member 3		PRO_0000363835
Regions
	Transmembrane	30 – 50	21	Potential
	Transmembrane	236 – 256	21	Potential
	Transmembrane	278 – 298	21	Potential
	Transmembrane	311 – 331	21	Potential
	Transmembrane	340 – 360	21	Potential
	Transmembrane	362 – 382	21	Potential
	Transmembrane	412 – 432	21	Potential
	Transmembrane	860 – 880	21	Potential
	Transmembrane	985 – 1005	21	Potential
	Transmembrane	1026 – 1046	21	Potential
	Transmembrane	1081 – 1101	21	Potential
	Transmembrane	1109 – 1129	21	Potential
	Transmembrane	1142 – 1162	21	Potential
	Transmembrane	1180 – 1200	21	Potential
	Transmembrane	1225 – 1245	21	Potential
	Domain	500 – 735	236	ABC transporter 1
	Domain	1292 – 1527	236	ABC transporter 2
	Nucleotide binding	536 – 543	8	ATP 1 Potential
	Nucleotide binding	1330 – 1337	8	ATP 2 Potential
	Compositional bias	1096 – 1099	4	Poly-Val
	Compositional bias	1185 – 1188	4	Poly-Phe
	Compositional bias	1265 – 1268	4	Poly-Pro
	Compositional bias	1627 – 1636	10	Poly-Asn
Experimental info
	Sequence conflict	6	1	F → S in AAL85296. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q54BT5-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 1585990ACA7FE5F5	FASTA	1,702	191,800
	10 20 30 40 50 60 MGEFKFQLVT LLKKNSLLKG KSKIKFIGEI LAPMIVIGIL FGLLYLSAII QPDFSPRYAS 70 80 90 100 110 120 GFTEVVGRLK KLLVATNGPL VPYQQTIVNN LRKQIKLAHP DYTNEYIDQC FEIFQDFESM 130 140 150 160 170 180 QGYFLDPENY RGVMGGLWFD ENDYRYNAPK VLKYSISVDA DYTNDNNIQI SPRSDSQIYL 190 200 210 220 230 240 RHYFTQIQTA VDQAIFMAQN VEIPMVVTGQ RFPNPYIHLW QTWTDGRNMI LKETGGIFIT 250 260 270 280 290 300 AAIFVGLFTT ITNMVMEKES KILEAMKIMG LHSLPYYVSI AISSCYTIIP STIIVIVVLK 310 320 330 340 350 360 GSQLIWTTQW YILTIILILF SISLILLAFI LSKFFNRSKF AGLVCFLIVL IMAGIGIAVN 370 380 390 400 410 420 HINVSTTVKL IFCLLSPVAI SLANYSMSMK DLELVKIVNP DWSIIVSENQ VIGMLILDVV 430 440 450 460 470 480 LYAALVWYID NIISGEFGQS KPFYFFLTKS YWCKKNANEN DLVDLSKAIE SPLYLRKKDL 490 500 510 520 530 540 DYNNSQDFEL NEIHSSKATI QIRKLRKEFK TGDGKRVAVD DLSIDMYQDR IHCFLGPNGS 550 560 570 580 590 600 GKSTTIGMLT GLITCTRGSA LINGLDINQN IDLIRKNIGV VLQQDIIWDN LTVLEHLIFY 610 620 630 640 650 660 AQLKGYSNLK EAKTEAKKMG IEVGLELKLH NKAGTLSGGQ KRKLCLGIAF IGPNSNILFL 670 680 690 700 710 720 DEVSSGLDPL SRSEVQDFII SKKKGKTIIL STHYMDEADL LGDTISIIAH GKLKCNGSPL 730 740 750 760 770 780 FLKNRFGVGY LLTITKKSTE FNKDSVMEIT NKYIKQAHIL SDAGTELSIR LPMESLPMFS 790 800 810 820 830 840 QYFKHLEDCK NQLLIDSYGI SISTLEEVFL KIGQETLKST PNFNDPAVKE ALSTKSSGVK 850 860 870 880 890 900 VGQQLKGLLI KRICTTKKDF KSFMFSIVVP LIILALGLVM YKNMRTIETF NDVTTPLTFS 910 920 930 940 950 960 IDDYGDNIYV PWSISGQNQA IDLRIKNSIG KSNHSKLLPA DELEDYLTLN YEGNPGAFAF 970 980 990 1000 1010 1020 GKTIIEDIEM LSFKVYYNRD YLHALPIYIN FVDNLMLSNL GGVGIQTTSR PFQHIKSKFE 1030 1040 1050 1060 1070 1080 LATEKINFSA IIFFIILTLA AFALVVASHA GNIAQERAAR IKRLLYISGL KKYVYWLSNL 1090 1100 1110 1120 1130 1140 IWDYVLTFIM VIFLAVVVVI IDSKFRNQFP LFICALVLFV TAIIPLSYLF SYCWSSHGKA 1150 1160 1170 1180 1190 1200 TGFIFGIHFG IGLLMTVTCF ILRIWVIKDD NDILQTITDI IDLVFFFFSP FYCFSKVMVI 1210 1220 1230 1240 1250 1260 ISNFPGTTRL GESYIANYWG IKFGLPPVCF LALHTLVWTI WIMVLDYYPE LRGKYRKGRN 1270 1280 1290 1300 1310 1320 EKSSPPPPSD EDSDVSHERS KVLSFETSND PIIMRDFFKL YKGKGKAKDN LAVYNTSLSI 1330 1340 1350 1360 1370 1380 PKGQTFGLLG LNGAGKSTTL GCLSGEVIPS GGEIFVNGFN IQTQRLDALR SVGFCHQYNS 1390 1400 1410 1420 1430 1440 LIGLLSAREQ IRLYCRIKGI EESKIQETVE AFIKMMDLGS IGNSNVAGYS GGNKRKVALS 1450 1460 1470 1480 1490 1500 VAIVGNPSVC FLDEVSAGVD PVVARFMWNV ITELKKDKVI ILTTHSMLEC SAVCDRLTIM 1510 1520 1530 1540 1550 1560 KSGKMMCLGS IQHIKDKFGS GYSIDVKFKK EYLLSGINLF QKELPNAKLV DHHDLSASFE 1570 1580 1590 1600 1610 1620 LPNSLDSPIQ LSKIFSIIER NLKPILNDYS VGQTSIDHIF LKLTNLNQQK IKNQQKESIE 1630 1640 1650 1660 1670 1680 NHIIDINNNN NNNNNNSYLK NHKKTTSNNS ILTNNSTTKN FGSSNFLDLE SDNTYLNNLK 1690 1700 YLEDDDFNIE MPPYQNSLKK SF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF465305 Genomic DNA. Translation: AAL85296.1. AAFI02000210 Genomic DNA. Translation: EAL60720.1.
RefSeq	XP_629134.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3385797.
GenomeReviews	Gene locus abcA3 in contig CM000155_GR.
KEGG	ddi:DDB_0201662.
Organism-specific databases
dictyBase	DDB_G0293436. abcA3.
Phylogenomic databases
OMA	KNANEND
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA3_DICDI

Accession

Primary (citable) accession number: Q54BT5
Secondary accession number(s): Q8T6J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	November 24, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)