Reviewed,
UniProtKB/Swiss-Prot Q54BK1 (GGPPS_DICDI)
Last modified
February 9, 2010.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Geranylgeranyl pyrophosphate synthetase Short name=GGPP synthetase Short name=GGPPSase Alternative name(s): Geranylgeranyl diphosphate synthase Including the following 3 domains: 1- Recommended name: Dimethylallyltranstransferase EC=2.5.1.1 2- Recommended name: Geranyltranstransferase EC=2.5.1.10 3- Recommended name: Farnesyltranstransferase EC=2.5.1.29 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins By similarity. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| Cofactor | Binds 3 magnesium ions per subunit By similarity. |
| Pathway | |
| Subunit structure | Homooligomer By similarity. |
| Subcellular location | Cytoplasm Potential. |
| Sequence similarities | Belongs to the FPP/GGPP synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activityInferred from electronic annotation. Source: EC geranyltranstransferase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | Geranylgeranyl pyrophosphate synthetase | PRO_0000327749 | |||||
Sites | |||||||||
| Metal binding | 71 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 71 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 75 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 75 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 195 | 1 | Magnesium 3 By similarity | ||||||
| Binding site | 32 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 35 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 64 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 80 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 81 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 158 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 159 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 192 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 209 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 219 | 1 | Dimethylallyl diphosphate By similarity | ||||||
Sequences
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References
| [1] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000218 Genomic DNA. Translation: EAL60606.1. |
| RefSeq | XP_629028.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2FVI based on UniProtKB O95749. |
| SMR | Q54BK1. Positions 18-299. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q54BK1. |
Genome annotation databases | |
| GeneID | 8629314. |
| KEGG | ddi:DDB_0233098. |
Organism-specific databases | |
| dictyBase | DDB_G0293588. ggps1. |
Phylogenomic databases | |
| eggNOG | KOG0777. |
| HOGENOM | HBG397395. |
| OMA | DIEDNSI. |
| PhylomeDB | Q54BK1. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.1. 424. 2.5.1.10. 424. 2.5.1.29. 424. |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| PANTHER | PTHR12001. Polyprenyl_synt. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| PROSITE | PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GGPPS_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q54BK1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


