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Reviewed, UniProtKB/Swiss-Prot Q54BK1 (GGPPS_DICDI)

Last modified June 16, 2009. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPPSase
Alternative name(s):
    Geranylgeranyl diphosphate synthase
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29
Gene names
Name: ggps1
ORF Names: DDB_G0293588
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins By similarity.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.

Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Pathway

Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1.

Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.

Subunit structure

Homooctamer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the FPP/GGPP synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Geranylgeranyl pyrophosphate synthetase
PRO_0000327749

Sequences

Sequence LengthMass (Da)Tools
Q54BK1-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: C0DD91100FBC4F88

FASTA30334,876
        10         20         30         40         50         60 
MENSKIHFSY PLDKSDFKLI EPYTYICESS GKGFRNALIK SFDYWLKVGD EKVQDISKVI 

        70         80         90        100        110        120 
QGLHGASLLI DDIEDNSKLR RGKPVAHSIY GIPQTINSAN FVYFLIMDQC NKLGDPKATT 

       130        140        150        160        170        180 
IFIEELIRLH RGQGYDIFWR DTNTSPSEQE YMNMVNEKTG GLFRLGLRLL QAFSDNNTNY 

       190        200        210        220        230        240 
IDLVEDLGMY YQIRDDLINL VSVDYQQNKS FCEDISEGKF SFPIIHAINA DSNDNRLLRI 

       250        260        270        280        290        300 
LKQKTEDRSV KEHALEYIKS KGSLEYTEKK LNVLKEKIIK QINDLGGNPI LMKLMESLEN 


SSI 

« Hide

Cross-references

Sequence databases

AAFI02000218 Genomic DNA. Translation: EAL60606.1.
RefSeqXP_629028.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3385670.
KEGGddi:DDB_0233098.

Organism-specific databases

dictyBaseDDB_G0293588. ggps1.

Phylogenomic databases

OMAQ54BK1. DDYANLS.

Enzyme and pathway databases

BRENDA2.5.1.1. 424.
2.5.1.10. 424.
2.5.1.29. 424.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
PROSITEPS00723. POLYPRENYL_SYNTHET_1. 1 hit.
PS00444. POLYPRENYL_SYNTHET_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGPPS_DICDI
AccessionPrimary (citable) accession number: Q54BK1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents