Q54BC9 (DYRK2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase dyrk2
EC=2.7.12.1

Alternative name(s):
Dual specificity tyrosine-phosphorylation-regulated kinase 2

Gene names

Name:	dyrk2
ORF Names:	DDB_G0293750

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 915	915	Probable serine/threonine-protein kinase dyrk2		PRO_0000362010
Regions
	Domain	605 – 902	298	Protein kinase
	Nucleotide binding	611 – 619	9	ATP By similarity
	Compositional bias	58 – 64	7	Poly-Asn
	Compositional bias	65 – 77	13	Poly-Thr
	Compositional bias	170 – 182	13	Poly-Ser
	Compositional bias	194 – 204	11	Poly-Ser
	Compositional bias	207 – 210	4	Poly-Asn
	Compositional bias	295 – 298	4	Poly-Pro
	Compositional bias	299 – 302	4	Poly-Ser
	Compositional bias	303 – 318	16	Poly-Thr
	Compositional bias	319 – 325	7	Poly-Ser
	Compositional bias	378 – 391	14	Poly-Ser
	Compositional bias	439 – 445	7	Poly-Thr
	Compositional bias	448 – 462	15	Poly-Ser
	Compositional bias	466 – 472	7	Poly-Ser
	Compositional bias	488 – 499	12	Poly-Thr
	Compositional bias	514 – 531	18	Poly-Thr
Sites
	Active site	731	1	Proton acceptor By similarity
	Binding site	634	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54BC9 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: A7BFF787F80278D6	FASTA	915	98,276
	10 20 30 40 50 60 MTSLHKQIIE SHNNDITKLK SSMSTRAAAR RSVCLSSMSY TLGADDVTPI TSNTTPSNNN 70 80 90 100 110 120 NNNNTTTTIT TTTTTPTISP LKQSTTGSII PKSILVTKSG SKEEPIVSSS KSSSNSSSIN 130 140 150 160 170 180 NNFNNLYSAS TFSSSTKKVH ERPSINPGFR KPREALLSGN SDSGIIKKPS SSSTSSSSSS 190 200 210 220 230 240 SSTTSNIKAP IQISHSSNSG SSSSGGNNNN SDDNSGSSTI KHTAASLSKM KLSPSHTISD 250 260 270 280 290 300 SPRSSTMKSR SVSISNGSLF SPTNTSVNNS NNNTSSNIKT PTKSSISENL DQNTPPPPSS 310 320 330 340 350 360 SSTTKTPTAT TTTTTTTTSS SSSTSTNTTP SKSSVDDVFA RLANVSKPAI KSRSLSVSAS 370 380 390 400 410 420 LARVEQSPPT KDKGDKESSS SSSSSSSSFS SKFTKILRSS SKTPTPTSSN TTVQPSTTSL 430 440 450 460 470 480 SASKISSRKD TKSLSSFSTT TTTTTLKSSS SSSSSSSSSS KSNIASSSSS SSNNLTNLLT 490 500 510 520 530 540 QSQSISSTST STTTTPTSTS PTLASSMSVL SSPTSTTTTS TSTTSTTTTP TKSSCTIITP 550 560 570 580 590 600 SIALKLYIND LTSAEQSEIL DYPQIYFTGN TNKKTKFNSQ LPNNGYDNDI GEYKVVERDH 610 620 630 640 650 660 IAYRFEIVSI LGQGSFCQVV KGYDYKTGEM VALKILRNQK RFHNQALTEI KILEYLKTND 670 680 690 700 710 720 PNSTASIVHL NNYFYFRNHL ILTFELLSMN LYDFLKVNHF QGYNLNLVRR FGAQILTSLR 730 740 750 760 770 780 FLSKRNIIHA DLKPENILLK SPTKSGIKLI DFGSSCFENE QIFTYIQSRF YRSPEVILGT 790 800 810 820 830 840 KYDKSIDIWS LGCILVEIFT GVPLFPGSDE PEQLACIMEV LGAPPKSVID NSTRKDIFFE 850 860 870 880 890 900 DDGTPKPVKN STTGELYTIG TKSFKDSIRS GDEDFDNFIL DCLKWEPSQR ITAEQGLKHD 910 WIIKVIAPTA PSTPS

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000219 Genomic DNA. Translation: EAL60552.1.
RefSeq	XP_628965.1. XM_628963.1.
3D structure databases
HSSP	HSSP built from PDB template 2EXE based on UniProtKB P49761.
ProteinModelPortal	Q54BC9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0230102; DDB0230102; DDB_G0293750.
GeneID	8629393.
GenomeReviews	Gene locus dyrk2 in contig CM000155_GR.
KEGG	ddi:DDB_G0293750.
Organism-specific databases
dictyBase	DDB_G0293750. dyrk2.
Phylogenomic databases
eggNOG	KOG0667.
GeneTree	EPrGT00060000009507.
InParanoid	Q54BC9.
OMA	ERDHIAY.
PhylomeDB	Q54BC9.
ProtClustDB	CLSZ2846555.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K08825.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYRK2_DICDI

Accession

Primary (citable) accession number: Q54BC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)