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Protein

Proteasome subunit beta type-5

Gene

psmB5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: dictyBase
  • proteolysis involved in cellular protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174113 SCF-beta-TrCP mediated degradation of Emi1
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-382556 ABC-family proteins mediated transport
R-DDI-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.012

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-5 (EC:3.4.25.1)
Gene namesi
Name:psmB5
ORF Names:DDB_G0293784
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293784 psmB5

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, beta-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003274841 – 62Removed in mature formBy similarityAdd BLAST62
ChainiPRO_000032748563 – 272Proteasome subunit beta type-5Add BLAST210

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiQ54BC8

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.1 Publication

Protein-protein interaction databases

STRINGi44689.DDB0232959

Structurei

3D structure databases

ProteinModelPortaliQ54BC8
SMRiQ54BC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0175 Eukaryota
ENOG410XQRP LUCA
InParanoidiQ54BC8
KOiK02737
OMAiTMCAGVT
PhylomeDBiQ54BC8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR000243 Pept_T1A_subB
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54BC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINIDFDNIE QSQPTLYDTL ASDVKFLNTP HFELPPNANP GDFLRETFDH
60 70 80 90 100
PSAPKALEFA HGTTTLAFVY GGGIIVSVDS KSTQGPYVAS RSVKKVIEIT
110 120 130 140 150
PTLLGTMAGG AADCSFWERE LGRRCRLYEL RNKELISVAA ASKILANIVY
160 170 180 190 200
SYKGYGLSMG TMITGWDKTG PQLYYVDNDG TRLHGQRFSC GSGSTYAYGV
210 220 230 240 250
LDTGFKWDMN DEEAYELGRR AVYHATHRDA YSGGAINVYH VQKDGWKKIS
260 270
SDDCFKLYQK YYNIVPINKP AN
Length:272
Mass (Da):30,280
Last modified:May 24, 2005 - v1
Checksum:i9C6D656C754404C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000219 Genomic DNA Translation: EAL60569.1
RefSeqiXP_628966.1, XM_628964.1

Genome annotation databases

EnsemblProtistsiEAL60569; EAL60569; DDB_G0293784
GeneIDi8629394
KEGGiddi:DDB_G0293784

Similar proteinsi

Entry informationi

Entry nameiPSB5_DICDI
AccessioniPrimary (citable) accession number: Q54BC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health