Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial substrate carrier family protein Z

Gene

mcfZ

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-DDI-70263. Gluconeogenesis.
R-DDI-75105. Fatty acyl-CoA biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein Z
Gene namesi
Name:mcfZ
Synonyms:mitA
ORF Names:DDB_G0293874
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293874. mcfZ.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19Mitochondrial intermembraneBy similarityAdd BLAST19
Transmembranei20 – 37Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini38 – 65Mitochondrial matrixBy similarityAdd BLAST28
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 117Mitochondrial intermembraneBy similarityAdd BLAST31
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 174Mitochondrial matrixBy similarityAdd BLAST36
Transmembranei175 – 191Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini192 – 212Mitochondrial intermembraneBy similarityAdd BLAST21
Transmembranei213 – 229Helical; Name=5Sequence analysisAdd BLAST17
Topological domaini230 – 275Mitochondrial matrixBy similarityAdd BLAST46
Transmembranei276 – 296Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini297 – 301Mitochondrial intermembraneBy similarity5

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855321 – 301Mitochondrial substrate carrier family protein ZAdd BLAST301

Proteomic databases

PaxDbiQ54B67.

Expressioni

Developmental stagei

Present in vegetative cells but expression decreases rapidly after the initiation of development. Accumulates also in prestalk cells.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0229992.

Structurei

3D structure databases

ProteinModelPortaliQ54B67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 101Solcar 1Add BLAST88
Repeati116 – 200Solcar 2Add BLAST85
Repeati210 – 293Solcar 3Add BLAST84

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0756. Eukaryota.
ENOG410YAYP. LUCA.
InParanoidiQ54B67.
KOiK15100.
OMAiVMRLGRT.
PhylomeDBiQ54B67.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q54B67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKEENKQQ QHVNFPWKRL VAGAVAGTAD VWACHPLDRI KTQLQNNPGK
60 70 80 90 100
SIVGTFGDIV SKGKGFTGGV NALYEGILPM TAEAIFKVGI RYFAFSWFTE
110 120 130 140 150
QYKTTVYKGE TLNKKQQFGA NLLGGAFAGT IESFVVVIPC ELLKVRHMTQ
160 170 180 190 200
EHNKSFGTVF RDVLREEGFQ GLYKGGSATL LRQITNHMIR FPTFYAISDY
210 220 230 240 250
LKGGDHSVHL PVWQNLSAGA IAGTASTLFN NPLDTIKTRM QKQGQNQTTM
260 270 280 290 300
QVVRGIYQET GVKGYWAGVI PRILRVAPGQ AITWAVVELV MGILEPSSKK

H
Length:301
Mass (Da):33,268
Last modified:May 24, 2005 - v1
Checksum:i57BC42A3C09EBA30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000223 Genomic DNA. Translation: EAL60508.1.
RefSeqiXP_628921.1. XM_628919.1.

Genome annotation databases

EnsemblProtistsiEAL60508; EAL60508; DDB_G0293874.
GeneIDi8629463.
KEGGiddi:DDB_G0293874.

Similar proteinsi

Entry informationi

Entry nameiMCFZ_DICDI
AccessioniPrimary (citable) accession number: Q54B67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families