Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q54B37

- GXCJ_DICDI

UniProt

Q54B37 - GXCJ_DICDI

Protein

RhoGEF domain-containing protein gxcJ

Gene

gxcJ

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GTPase-activating protein.By similarity

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_204273. Rho GTPase cycle.
    REACT_204470. PPARA activates gene expression.
    REACT_211603. NRAGE signals death through JNK.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RhoGEF domain-containing protein gxcJ
    Gene namesi
    Name:gxcJ
    ORF Names:DDB_0233315
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0293978. gxcJ.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11551155RhoGEF domain-containing protein gxcJPRO_0000377437Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0233315.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54B37.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini700 – 874175DHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili192 – 25766Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi119 – 15335Poly-AsnAdd
    BLAST
    Compositional biasi172 – 1754Poly-Asn
    Compositional biasi282 – 30322Poly-AsnAdd
    BLAST
    Compositional biasi434 – 4407Poly-Pro
    Compositional biasi444 – 4496Poly-Ser
    Compositional biasi491 – 4966Poly-Ser
    Compositional biasi497 – 50913Poly-ThrAdd
    BLAST
    Compositional biasi610 – 6189Poly-Asn
    Compositional biasi631 – 6377Poly-Asn
    Compositional biasi652 – 66110Poly-Gln
    Compositional biasi680 – 6889Poly-Thr
    Compositional biasi1017 – 102610Poly-Ser
    Compositional biasi1047 – 106014Poly-AsnAdd
    BLAST
    Compositional biasi1128 – 113710Poly-Gln

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiKOG3519.
    InParanoidiQ54B37.
    OMAiSTINCIN.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    InterProiIPR000219. DH-domain.
    [Graphical view]
    PfamiPF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54B37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIHPFIQSF TEIIDNRMKL GNNMEGVIEC KNCQTDTPKC NKVCLTCNSD     50
    IGERCWRCNY LGKINSKFCF RCNVKLHPTS IPPKDSIQPI PIFTKHPIAS 100
    TLLINKSIIP TQSENNSIND NNNNNNNNNN NNNNNNNNNN NNNNNNNNNT 150
    NNNDSKIIDA TITNTKNNNT TNNNNISNNN SSNIISNSNN NNNNNNNNNN 200
    NNNNNNNNNN NLNFLKKSTS CDNGSFESIS DSISPIKDII NNINNRTKDI 250
    EKLNSALPLN KKSNSSTSWS NFNTFKNNSK TNNNNNNNNN NNNNNNNNNN 300
    NNNYKPTITS SQTQPSLMEN SKDIDKKEKI PSNINNNRST TIIYKYQEDN 350
    SEDYTDDGDF EEFQINSNLT SESSSIDSLI IKDGVIATTV TSSTINCIND 400
    NNFDPDQLSS STSSIKKPKL FYSITKKKLV SQSPPPPQPP FLASASSSST 450
    TTITTTDSLE KSIKDSTPIA TTLVNDYQNQ NQNLNNESAA SSSSLSTTTT 500
    TTTTTTTTTL LPDSQTNLNN LIFIEKLNND LSGSIETLNN SLNNSLNSLN 550
    SSFNFRLNLN SITNNEDKRL SNSSLLDEII DAFPSPPSKN PYISVLNTSG 600
    GIGSNSNSSN NNNSNSNNIT NSNSSSFSKK NSNNNNNYQP VISLPIPIVN 650
    HQQQQQQQQL QTAAILGNNN INFIQNPSST STTTTTTTAS TTTILIKSDH 700
    RTNLIKEILT TELDYVNDLE TIINVFCKPL RDFISNEDSA SIFSNIEQIW 750
    QINKQLYENL ISNTLTIGQV FSNMSDSLKV YSVYCNYHQK SLDSLNQLLK 800
    TPQNESFFDQ LLSKPELRGM GPHSFLIKPV QRICKYPLLL KELLKATAED 850
    HFDYPQLILA VEKIEKIVGT INSQKKEMET WQRTMQLIQN LKGADNLQLL 900
    AANRHLILEG SLHLVIGFTE NAEKKNSSLK FKKGVYFLFN DLFLFTKQKG 950
    TTYKLLFYTQ LDNVLIHANV SNCFPADKSV FSLVEIGVGG RKWTFCNTNS 1000
    NSSNISNSGN SSGIINSSSS SSGSCSNGGN SSGYNNLNNT CGIYSGNSNN 1050
    NNNNNNNNNN IFSTIQKLIE KTWEDKFMGQ SSVSHRLSIP STSSPNNGAS 1100
    LNGNSSSNSS STSISTVGSP NVTSAAKQQQ QLQQQQQSSK KRNRRLVKSL 1150
    VNIKT 1155
    Length:1,155
    Mass (Da):127,930
    Last modified:May 24, 2005 - v1
    Checksum:iBC01765B3D694494
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000224 Genomic DNA. Translation: EAL60488.1.
    RefSeqiXP_628879.1. XM_628877.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233315; DDB0233315; DDB_G0293978.
    GeneIDi8629495.
    KEGGiddi:DDB_G0293978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000224 Genomic DNA. Translation: EAL60488.1 .
    RefSeqi XP_628879.1. XM_628877.1.

    3D structure databases

    ProteinModelPortali Q54B37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0233315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233315 ; DDB0233315 ; DDB_G0293978 .
    GeneIDi 8629495.
    KEGGi ddi:DDB_G0293978.

    Organism-specific databases

    dictyBasei DDB_G0293978. gxcJ.

    Phylogenomic databases

    eggNOGi KOG3519.
    InParanoidi Q54B37.
    OMAi STINCIN.

    Enzyme and pathway databases

    Reactomei REACT_204273. Rho GTPase cycle.
    REACT_204470. PPARA activates gene expression.
    REACT_211603. NRAGE signals death through JNK.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    InterProi IPR000219. DH-domain.
    [Graphical view ]
    Pfami PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiGXCJ_DICDI
    AccessioniPrimary (citable) accession number: Q54B37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3