Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q54B37

- GXCJ_DICDI

UniProt

Q54B37 - GXCJ_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

RhoGEF domain-containing protein gxcJ

Gene

gxcJ

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GTPase-activating protein.By similarity

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_204273. Rho GTPase cycle.
REACT_204470. PPARA activates gene expression.
REACT_211603. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
RhoGEF domain-containing protein gxcJ
Gene namesi
Name:gxcJ
ORF Names:DDB_0233315
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 6, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293978. gxcJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11551155RhoGEF domain-containing protein gxcJPRO_0000377437Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0233315.

Structurei

3D structure databases

ProteinModelPortaliQ54B37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini700 – 874175DHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili192 – 25766Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi119 – 15335Poly-AsnAdd
BLAST
Compositional biasi172 – 1754Poly-Asn
Compositional biasi282 – 30322Poly-AsnAdd
BLAST
Compositional biasi434 – 4407Poly-Pro
Compositional biasi444 – 4496Poly-Ser
Compositional biasi491 – 4966Poly-Ser
Compositional biasi497 – 50913Poly-ThrAdd
BLAST
Compositional biasi610 – 6189Poly-Asn
Compositional biasi631 – 6377Poly-Asn
Compositional biasi652 – 66110Poly-Gln
Compositional biasi680 – 6889Poly-Thr
Compositional biasi1017 – 102610Poly-Ser
Compositional biasi1047 – 106014Poly-AsnAdd
BLAST
Compositional biasi1128 – 113710Poly-Gln

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3519.
InParanoidiQ54B37.
OMAiSTINCIN.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54B37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIHPFIQSF TEIIDNRMKL GNNMEGVIEC KNCQTDTPKC NKVCLTCNSD
60 70 80 90 100
IGERCWRCNY LGKINSKFCF RCNVKLHPTS IPPKDSIQPI PIFTKHPIAS
110 120 130 140 150
TLLINKSIIP TQSENNSIND NNNNNNNNNN NNNNNNNNNN NNNNNNNNNT
160 170 180 190 200
NNNDSKIIDA TITNTKNNNT TNNNNISNNN SSNIISNSNN NNNNNNNNNN
210 220 230 240 250
NNNNNNNNNN NLNFLKKSTS CDNGSFESIS DSISPIKDII NNINNRTKDI
260 270 280 290 300
EKLNSALPLN KKSNSSTSWS NFNTFKNNSK TNNNNNNNNN NNNNNNNNNN
310 320 330 340 350
NNNYKPTITS SQTQPSLMEN SKDIDKKEKI PSNINNNRST TIIYKYQEDN
360 370 380 390 400
SEDYTDDGDF EEFQINSNLT SESSSIDSLI IKDGVIATTV TSSTINCIND
410 420 430 440 450
NNFDPDQLSS STSSIKKPKL FYSITKKKLV SQSPPPPQPP FLASASSSST
460 470 480 490 500
TTITTTDSLE KSIKDSTPIA TTLVNDYQNQ NQNLNNESAA SSSSLSTTTT
510 520 530 540 550
TTTTTTTTTL LPDSQTNLNN LIFIEKLNND LSGSIETLNN SLNNSLNSLN
560 570 580 590 600
SSFNFRLNLN SITNNEDKRL SNSSLLDEII DAFPSPPSKN PYISVLNTSG
610 620 630 640 650
GIGSNSNSSN NNNSNSNNIT NSNSSSFSKK NSNNNNNYQP VISLPIPIVN
660 670 680 690 700
HQQQQQQQQL QTAAILGNNN INFIQNPSST STTTTTTTAS TTTILIKSDH
710 720 730 740 750
RTNLIKEILT TELDYVNDLE TIINVFCKPL RDFISNEDSA SIFSNIEQIW
760 770 780 790 800
QINKQLYENL ISNTLTIGQV FSNMSDSLKV YSVYCNYHQK SLDSLNQLLK
810 820 830 840 850
TPQNESFFDQ LLSKPELRGM GPHSFLIKPV QRICKYPLLL KELLKATAED
860 870 880 890 900
HFDYPQLILA VEKIEKIVGT INSQKKEMET WQRTMQLIQN LKGADNLQLL
910 920 930 940 950
AANRHLILEG SLHLVIGFTE NAEKKNSSLK FKKGVYFLFN DLFLFTKQKG
960 970 980 990 1000
TTYKLLFYTQ LDNVLIHANV SNCFPADKSV FSLVEIGVGG RKWTFCNTNS
1010 1020 1030 1040 1050
NSSNISNSGN SSGIINSSSS SSGSCSNGGN SSGYNNLNNT CGIYSGNSNN
1060 1070 1080 1090 1100
NNNNNNNNNN IFSTIQKLIE KTWEDKFMGQ SSVSHRLSIP STSSPNNGAS
1110 1120 1130 1140 1150
LNGNSSSNSS STSISTVGSP NVTSAAKQQQ QLQQQQQSSK KRNRRLVKSL

VNIKT
Length:1,155
Mass (Da):127,930
Last modified:May 24, 2005 - v1
Checksum:iBC01765B3D694494
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000224 Genomic DNA. Translation: EAL60488.1.
RefSeqiXP_628879.1. XM_628877.1.

Genome annotation databases

EnsemblProtistsiDDB0233315; DDB0233315; DDB_G0293978.
GeneIDi8629495.
KEGGiddi:DDB_G0293978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000224 Genomic DNA. Translation: EAL60488.1 .
RefSeqi XP_628879.1. XM_628877.1.

3D structure databases

ProteinModelPortali Q54B37.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233315 ; DDB0233315 ; DDB_G0293978 .
GeneIDi 8629495.
KEGGi ddi:DDB_G0293978.

Organism-specific databases

dictyBasei DDB_G0293978. gxcJ.

Phylogenomic databases

eggNOGi KOG3519.
InParanoidi Q54B37.
OMAi STINCIN.

Enzyme and pathway databases

Reactomei REACT_204273. Rho GTPase cycle.
REACT_204470. PPARA activates gene expression.
REACT_211603. NRAGE signals death through JNK.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
InterProi IPR000219. DH-domain.
[Graphical view ]
Pfami PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGXCJ_DICDI
AccessioniPrimary (citable) accession number: Q54B37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 24, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3