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Protein

RhoGEF domain-containing protein gxcJ

Gene

gxcJ

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GTPase-activating protein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
RhoGEF domain-containing protein gxcJ
Gene namesi
Name:gxcJ
ORF Names:DDB_0233315
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0293978. gxcJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003774371 – 1155RhoGEF domain-containing protein gxcJAdd BLAST1155

Proteomic databases

PaxDbiQ54B37.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0233315.

Structurei

3D structure databases

ProteinModelPortaliQ54B37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini700 – 874DHPROSITE-ProRule annotationAdd BLAST175

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili192 – 257Sequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi119 – 153Poly-AsnAdd BLAST35
Compositional biasi172 – 175Poly-Asn4
Compositional biasi282 – 303Poly-AsnAdd BLAST22
Compositional biasi434 – 440Poly-Pro7
Compositional biasi444 – 449Poly-Ser6
Compositional biasi491 – 496Poly-Ser6
Compositional biasi497 – 509Poly-ThrAdd BLAST13
Compositional biasi610 – 618Poly-Asn9
Compositional biasi631 – 637Poly-Asn7
Compositional biasi652 – 661Poly-Gln10
Compositional biasi680 – 688Poly-Thr9
Compositional biasi1017 – 1026Poly-Ser10
Compositional biasi1047 – 1060Poly-AsnAdd BLAST14
Compositional biasi1128 – 1137Poly-Gln10

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ITRU. Eukaryota.
ENOG4110XZ1. LUCA.
InParanoidiQ54B37.
OMAiSTINCIN.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54B37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIHPFIQSF TEIIDNRMKL GNNMEGVIEC KNCQTDTPKC NKVCLTCNSD
60 70 80 90 100
IGERCWRCNY LGKINSKFCF RCNVKLHPTS IPPKDSIQPI PIFTKHPIAS
110 120 130 140 150
TLLINKSIIP TQSENNSIND NNNNNNNNNN NNNNNNNNNN NNNNNNNNNT
160 170 180 190 200
NNNDSKIIDA TITNTKNNNT TNNNNISNNN SSNIISNSNN NNNNNNNNNN
210 220 230 240 250
NNNNNNNNNN NLNFLKKSTS CDNGSFESIS DSISPIKDII NNINNRTKDI
260 270 280 290 300
EKLNSALPLN KKSNSSTSWS NFNTFKNNSK TNNNNNNNNN NNNNNNNNNN
310 320 330 340 350
NNNYKPTITS SQTQPSLMEN SKDIDKKEKI PSNINNNRST TIIYKYQEDN
360 370 380 390 400
SEDYTDDGDF EEFQINSNLT SESSSIDSLI IKDGVIATTV TSSTINCIND
410 420 430 440 450
NNFDPDQLSS STSSIKKPKL FYSITKKKLV SQSPPPPQPP FLASASSSST
460 470 480 490 500
TTITTTDSLE KSIKDSTPIA TTLVNDYQNQ NQNLNNESAA SSSSLSTTTT
510 520 530 540 550
TTTTTTTTTL LPDSQTNLNN LIFIEKLNND LSGSIETLNN SLNNSLNSLN
560 570 580 590 600
SSFNFRLNLN SITNNEDKRL SNSSLLDEII DAFPSPPSKN PYISVLNTSG
610 620 630 640 650
GIGSNSNSSN NNNSNSNNIT NSNSSSFSKK NSNNNNNYQP VISLPIPIVN
660 670 680 690 700
HQQQQQQQQL QTAAILGNNN INFIQNPSST STTTTTTTAS TTTILIKSDH
710 720 730 740 750
RTNLIKEILT TELDYVNDLE TIINVFCKPL RDFISNEDSA SIFSNIEQIW
760 770 780 790 800
QINKQLYENL ISNTLTIGQV FSNMSDSLKV YSVYCNYHQK SLDSLNQLLK
810 820 830 840 850
TPQNESFFDQ LLSKPELRGM GPHSFLIKPV QRICKYPLLL KELLKATAED
860 870 880 890 900
HFDYPQLILA VEKIEKIVGT INSQKKEMET WQRTMQLIQN LKGADNLQLL
910 920 930 940 950
AANRHLILEG SLHLVIGFTE NAEKKNSSLK FKKGVYFLFN DLFLFTKQKG
960 970 980 990 1000
TTYKLLFYTQ LDNVLIHANV SNCFPADKSV FSLVEIGVGG RKWTFCNTNS
1010 1020 1030 1040 1050
NSSNISNSGN SSGIINSSSS SSGSCSNGGN SSGYNNLNNT CGIYSGNSNN
1060 1070 1080 1090 1100
NNNNNNNNNN IFSTIQKLIE KTWEDKFMGQ SSVSHRLSIP STSSPNNGAS
1110 1120 1130 1140 1150
LNGNSSSNSS STSISTVGSP NVTSAAKQQQ QLQQQQQSSK KRNRRLVKSL

VNIKT
Length:1,155
Mass (Da):127,930
Last modified:May 24, 2005 - v1
Checksum:iBC01765B3D694494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000224 Genomic DNA. Translation: EAL60488.1.
RefSeqiXP_628879.1. XM_628877.1.

Genome annotation databases

EnsemblProtistsiEAL60488; EAL60488; DDB_G0293978.
GeneIDi8629495.
KEGGiddi:DDB_G0293978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000224 Genomic DNA. Translation: EAL60488.1.
RefSeqiXP_628879.1. XM_628877.1.

3D structure databases

ProteinModelPortaliQ54B37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233315.

Proteomic databases

PaxDbiQ54B37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL60488; EAL60488; DDB_G0293978.
GeneIDi8629495.
KEGGiddi:DDB_G0293978.

Organism-specific databases

dictyBaseiDDB_G0293978. gxcJ.

Phylogenomic databases

eggNOGiENOG410ITRU. Eukaryota.
ENOG4110XZ1. LUCA.
InParanoidiQ54B37.
OMAiSTINCIN.

Miscellaneous databases

PROiQ54B37.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGXCJ_DICDI
AccessioniPrimary (citable) accession number: Q54B37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: May 24, 2005
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.