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Protein
Submitted name:

Cofilin 2 (Muscle), isoform CRA_a

Gene

CFL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cofilin 2 (Muscle), isoform CRA_aImported
Submitted name:
Cofilin 2 (Muscle), isoform CRA_cImported
Submitted name:
Cofilin isoformImported
Submitted name:
cDNA, FLJ94864, Homo sapiens cofilin 2 (muscle) (CFL2), mRNAImported
Gene namesi
Name:CFL2Imported
ORF Names:hCG_21174Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000165410.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26424

PTM / Processingi

Proteomic databases

PRIDEiQ549N0

Expressioni

Gene expression databases

BgeeiENSG00000165410
ExpressionAtlasiQ549N0 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ549N0, 7 interactors

Structurei

3D structure databases

SMRiQ549N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HInterPro annotationAdd BLAST150

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1735 Eukaryota
ENOG41122P5 LUCA
HOVERGENiHBG000381
KOiK05765
OMAiGLYDATY
OrthoDBiEOG091G0PWC

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
PANTHERiPTHR11913 PTHR11913, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequencei

Sequence statusi: Complete.

Q549N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE
60 70 80 90 100
EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV
110 120 130 140 150
FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG
160
EKLGGNVVVS LEGKPL
Length:166
Mass (Da):18,737
Last modified:May 24, 2005 - v1
Checksum:i48B6CDCCAE9FE1CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087867 mRNA Translation: AAM10495.1
AK314157 mRNA Translation: BAG36842.1
CH471078 Genomic DNA Translation: EAW65908.1
CH471078 Genomic DNA Translation: EAW65910.1
CH471078 Genomic DNA Translation: EAW65911.1
RefSeqiNP_068733.1, NM_021914.7
NP_619579.1, NM_138638.4
UniGeneiHs.180141

Genome annotation databases

GeneIDi1073
KEGGihsa:1073

Similar proteinsi

Entry informationi

Entry nameiQ549N0_HUMAN
AccessioniPrimary (citable) accession number: Q549N0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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