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Protein

cAMP-dependent protein kinase inhibitor

Gene

PKIG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei16Important for inhibitionUniRule annotation1
Sitei19Important for inhibitionUniRule annotation1
Sitei20Important for inhibitionUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Protein kinase inhibitorUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitorUniRule annotation
Gene namesi
Name:PKIGImported
ORF Names:hCG_38104Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33351.

Expressioni

Gene expression databases

BgeeiENSG00000168734.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-10243311,EBI-10172134

Protein-protein interaction databases

IntActiQ549H9. 1 interactor.
STRINGi9606.ENSP00000338067.

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410J1ME. Eukaryota.
ENOG410ZDGT. LUCA.
HOVERGENiHBG104492.
OMAiEANTPDK.
OrthoDBiEOG091G13WE.

Family and domain databases

InterProiView protein in InterPro
IPR004171. cAMP_dep_PKI.
PfamiView protein in Pfam
PF02827. PKI. 1 hit.
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366. cAMP_dep_PKI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q549H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQVEGSAPD KEAGNQPQSS DGTTSS
Length:76
Mass (Da):7,910
Last modified:May 24, 2005 - v1
Checksum:iF01B4C73ED2CC6EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104256 mRNA. Translation: AAI04257.1.
BC104257 mRNA. Translation: AAI04258.1.
AF115966 mRNA. Translation: AAP97238.1.
AK312048 mRNA. Translation: BAG34984.1.
CH471077 Genomic DNA. Translation: EAW75908.1.
CH471077 Genomic DNA. Translation: EAW75910.1.
CH471077 Genomic DNA. Translation: EAW75911.1.
CH471077 Genomic DNA. Translation: EAW75912.1.
CH471077 Genomic DNA. Translation: EAW75913.1.
CH471077 Genomic DNA. Translation: EAW75914.1.
RefSeqiNP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
XP_016883103.1. XM_017027614.1.
XP_016883104.1. XM_017027615.1.
XP_016883105.1. XM_017027616.1.
UniGeneiHs.472831.

Genome annotation databases

GeneIDi11142.
KEGGihsa:11142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104256 mRNA. Translation: AAI04257.1.
BC104257 mRNA. Translation: AAI04258.1.
AF115966 mRNA. Translation: AAP97238.1.
AK312048 mRNA. Translation: BAG34984.1.
CH471077 Genomic DNA. Translation: EAW75908.1.
CH471077 Genomic DNA. Translation: EAW75910.1.
CH471077 Genomic DNA. Translation: EAW75911.1.
CH471077 Genomic DNA. Translation: EAW75912.1.
CH471077 Genomic DNA. Translation: EAW75913.1.
CH471077 Genomic DNA. Translation: EAW75914.1.
RefSeqiNP_001268373.1. NM_001281444.1.
NP_001268374.1. NM_001281445.1.
NP_008997.1. NM_007066.4.
NP_861520.1. NM_181804.2.
NP_861521.1. NM_181805.2.
XP_016883103.1. XM_017027614.1.
XP_016883104.1. XM_017027615.1.
XP_016883105.1. XM_017027616.1.
UniGeneiHs.472831.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ549H9. 1 interactor.
STRINGi9606.ENSP00000338067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11142.
KEGGihsa:11142.

Organism-specific databases

CTDi11142.
PharmGKBiPA33351.

Phylogenomic databases

eggNOGiENOG410J1ME. Eukaryota.
ENOG410ZDGT. LUCA.
HOVERGENiHBG104492.
OMAiEANTPDK.
OrthoDBiEOG091G13WE.

Miscellaneous databases

ChiTaRSiPKIG. human.
GenomeRNAii11142.

Gene expression databases

BgeeiENSG00000168734.

Family and domain databases

InterProiView protein in InterPro
IPR004171. cAMP_dep_PKI.
PfamiView protein in Pfam
PF02827. PKI. 1 hit.
PIRSFiPIRSF001667. PKI. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366. cAMP_dep_PKI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ549H9_HUMAN
AccessioniPrimary (citable) accession number: Q549H9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 10, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.