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Protein

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
ClusterinUniRule annotation
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Signal peptidei1 – 1717 PotentialImportedAdd
BLAST
Chaini18 – 448431 PotentialImportedPRO_5000057055Add
BLAST
Chaini22 – 448427ClusterinUniRule annotationPRO_5001405748Add
BLAST

Interactioni

Subunit structurei

Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022616.

Family & Domainsi

Sequence similaritiesi

Belongs to the clusterin family.UniRule annotation

Keywords - Domaini

SignalUniRule annotationImported

Phylogenomic databases

GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q549A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70 80 90 100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV
110 120 130 140 150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY
160 170 180 190 200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH
210 220 230 240 250
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI
260 270 280 290 300
HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ
310 320 330 340 350
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK
360 370 380 390 400
MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR
410 420 430 440
VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE
Length:448
Mass (Da):51,656
Last modified:May 24, 2005 - v1
Checksum:iA860600A6F8D47F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.2.
UniGeneiMm.200608.

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.2.
UniGeneiMm.200608.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Organism-specific databases

CTDi1191.
MGIiMGI:88423. Clu.

Phylogenomic databases

GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.

Miscellaneous databases

ChiTaRSiClu. mouse.
NextBioi282108.
SOURCEiSearch...

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
    Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
    (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  2. Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  4. "Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
    You K.H., Jeon J.H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Balb/cImported.
    Tissue: UterusImported.

Entry informationi

Entry nameiQ549A5_MOUSE
AccessioniPrimary (citable) accession number: Q549A5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.