Q549A5 (Q549A5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Clusterin RuleBase RU000629

Gene names

Name:

Clu MGI 88423

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the clusterin family. RuleBase RU000629

Ontologies

Keywords
Domain	Signal EMBL AAF06365.1
Gene Ontology (GO)
Biological_process	chaperone-mediated protein folding Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of protein homooligomerization Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of intrinsic apoptotic signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara protein stabilization Inferred from electronic annotation. Source: Compara response to misfolded protein Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara spherical high-density lipoprotein particle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential EMBL AAF06365.1
	Chain	18 – 448	431	Potential EMBL AAF06365.1		PRO_5000057055

Sequences

	Sequence		Length	Mass (Da)
	Q549A5 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: A860600A6F8D47F6	FASTA	448	51,656
	10 20 30 40 50 60 MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ GVKHIKTLIE 70 80 90 100 110 120 KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC 130 140 150 160 170 180 MKFYARVCRS GSGLVGQQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA 190 200 210 220 230 240 RASGIIDTLF QDRFFARELH DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH 250 260 270 280 290 300 NMFQPFFEMI HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ 310 320 330 340 350 360 CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK MLNTSSLLEQ 370 380 390 400 410 420 LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR VTEVVVKLFD SDPITVVLPE 430 440 EVSKDNPKFM DTVAEKALQE YRRKSRAE

References

[1]	"Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury." Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J. (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999) Cited for: NUCLEOTIDE SEQUENCE. Strain: SvJ/129 EMBL AAF06365.1.
[2]	Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SvJ/129 EMBL AAF06365.1.
[3]	"Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis." McLaughlin L., Zhu G., Mistry M., Ley-Ebert C., Stuart W.D., Florio C.J., Groen P.A., Witt S.A., Kimball T.R., Witte D.P., Harmony J.A., Aronow B.J. J. Clin. Invest. 106:1105-1113(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SvJ/129 EMBL AAF06365.1.
[4]	"Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion." You K.H., Jeon J.H. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Balb/c EMBL AAF67184.1. Tissue: Uterus EMBL AAF67184.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF182509 Genomic DNA. Translation: AAF06365.1. AF248057 mRNA. Translation: AAF67184.1.
IPI	IPI00320420.
RefSeq	NP_038520.2. NM_013492.2.
UniGene	Mm.200608.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12759.
KEGG	mmu:12759.
Organism-specific databases
CTD	1191.
MGI	MGI:88423. Clu.
Phylogenomic databases
GeneTree	ENSGT00530000063668.
HOVERGEN	HBG006908.
InParanoid	Q549A5.
OMA	SSPFYFW.
Gene expression databases
Genevestigator	Q549A5.
Family and domain databases
InterPro	IPR016016. Clusterin. IPR000753. Clusterin-like. IPR016015. Clusterin_C. IPR016014. Clusterin_N. [Graphical view]
PANTHER	PTHR10970:SF1. PTHR10970:SF1. 1 hit.
Pfam	PF01093. Clusterin. 1 hit. [Graphical view]
PIRSF	PIRSF002368. Clusterin. 1 hit.
SMART	SM00035. CLa. 1 hit. SM00030. CLb. 1 hit. [Graphical view]
PROSITE	PS00492. CLUSTERIN_1. 1 hit. PS00493. CLUSTERIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CLU. mouse.
NextBio	282108.
SOURCE	Search...

Entry information

Entry name

Q549A5_MOUSE

Accession

Primary (citable) accession number: Q549A5

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	May 29, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)