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Protein
Submitted name:

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. misfolded protein binding Source: MGI
  2. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. cell morphogenesis Source: MGI
  2. central nervous system myelin maintenance Source: MGI
  3. chaperone-mediated protein complex assembly Source: MGI
  4. chaperone-mediated protein folding Source: MGI
  5. intrinsic apoptotic signaling pathway Source: MGI
  6. microglial cell activation Source: MGI
  7. microglial cell proliferation Source: MGI
  8. negative regulation of beta-amyloid formation Source: MGI
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  10. negative regulation of protein homooligomerization Source: MGI
  11. positive regulation of apoptotic process Source: MGI
  12. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  13. positive regulation of neurofibrillary tangle assembly Source: MGI
  14. positive regulation of neuron death Source: MGI
  15. positive regulation of NF-kappaB transcription factor activity Source: MGI
  16. positive regulation of nitric oxide biosynthetic process Source: MGI
  17. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  18. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  19. positive regulation of tau-protein kinase activity Source: MGI
  20. positive regulation of tumor necrosis factor production Source: MGI
  21. protein import Source: MGI
  22. protein stabilization Source: MGI
  23. regulation of beta-amyloid clearance Source: MGI
  24. regulation of neuronal signal transduction Source: MGI
  25. regulation of neuron death Source: MGI
  26. response to misfolded protein Source: MGI
  27. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ClusterinImported
Submitted name:
Sulfated glycoprotein-2 isoform 1Imported
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: MGI
  2. blood microparticle Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular matrix Source: MGI
  5. extracellular space Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. mitochondrion Source: MGI
  8. neurofibrillary tangle Source: MGI
  9. perinuclear region of cytoplasm Source: MGI
  10. spherical high-density lipoprotein particle Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 PotentialImportedAdd
BLAST
Chaini18 – 448431 PotentialImportedPRO_5000057055Add
BLAST

Proteomic databases

PRIDEiQ549A5.

Expressioni

Gene expression databases

BgeeiQ549A5.
ExpressionAtlasiQ549A5. baseline and differential.
GenevestigatoriQ549A5.

Structurei

3D structure databases

ProteinModelPortaliQ549A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the clusterin family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.
PhylomeDBiQ549A5.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q549A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70 80 90 100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV
110 120 130 140 150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY
160 170 180 190 200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH
210 220 230 240 250
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI
260 270 280 290 300
HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ
310 320 330 340 350
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK
360 370 380 390 400
MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR
410 420 430 440
VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE
Length:448
Mass (Da):51,656
Last modified:May 23, 2005 - v1
Checksum:iA860600A6F8D47F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.2.
UniGeneiMm.200608.

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.2.
UniGeneiMm.200608.

3D structure databases

ProteinModelPortaliQ549A5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ549A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Organism-specific databases

CTDi1191.
MGIiMGI:88423. Clu.

Phylogenomic databases

GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.
PhylomeDBiQ549A5.

Miscellaneous databases

ChiTaRSiClu. mouse.
NextBioi282108.
SOURCEiSearch...

Gene expression databases

BgeeiQ549A5.
ExpressionAtlasiQ549A5. baseline and differential.
GenevestigatoriQ549A5.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
    Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
    (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1998)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  2. Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  4. "Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
    You K.H., Jeon J.H.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Balb/cImported.
    Tissue: UterusImported.

Entry informationi

Entry nameiQ549A5_MOUSE
AccessioniPrimary (citable) accession number: Q549A5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 23, 2005
Last sequence update: May 23, 2005
Last modified: March 31, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.