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Protein

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
ClusterinUniRule annotation
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Chaini22 – 448427ClusterinUniRule annotationPRO_5006532196Add
BLAST

Proteomic databases

MaxQBiQ549A5.

Interactioni

Subunit structurei

Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022616.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 226205CLbInterPro annotationAdd
BLAST
Domaini227 – 442216CLaInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili59 – 9335Sequence analysisAdd
BLAST
Coiled coili319 – 36446Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the clusterin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IHRB. Eukaryota.
ENOG410YYKB. LUCA.
GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.
PhylomeDBiQ549A5.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q549A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70 80 90 100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV
110 120 130 140 150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY
160 170 180 190 200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH
210 220 230 240 250
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI
260 270 280 290 300
HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ
310 320 330 340 350
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK
360 370 380 390 400
MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR
410 420 430 440
VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE
Length:448
Mass (Da):51,656
Last modified:May 24, 2005 - v1
Checksum:iA860600A6F8D47F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126444 Genomic DNA. No translation available.
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.3.
XP_006518567.1. XM_006518504.2.
UniGeneiMm.200608.

Genome annotation databases

EnsembliENSMUST00000022616; ENSMUSP00000022616; ENSMUSG00000022037.
GeneIDi12759.
KEGGimmu:12759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126444 Genomic DNA. No translation available.
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.3.
XP_006518567.1. XM_006518504.2.
UniGeneiMm.200608.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022616.

Proteomic databases

MaxQBiQ549A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022616; ENSMUSP00000022616; ENSMUSG00000022037.
GeneIDi12759.
KEGGimmu:12759.

Organism-specific databases

CTDi1191.
MGIiMGI:88423. Clu.

Phylogenomic databases

eggNOGiENOG410IHRB. Eukaryota.
ENOG410YYKB. LUCA.
GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.
PhylomeDBiQ549A5.

Miscellaneous databases

ChiTaRSiClu. mouse.
NextBioi282108.
SOURCEiSearch...

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
    Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
    (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  2. Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  4. "Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
    You K.H., Jeon J.H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Balb/cImported.
    Tissue: UterusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ549A5_MOUSE
AccessioniPrimary (citable) accession number: Q549A5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 13, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.