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Q549A5

- Q549A5_MOUSE

UniProt

Q549A5 - Q549A5_MOUSE

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Protein
Clusterin
Gene
Clu
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. chaperone-mediated protein folding Source: Ensembl
  2. intrinsic apoptotic signaling pathway Source: Ensembl
  3. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  4. negative regulation of protein homooligomerization Source: Ensembl
  5. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  6. positive regulation of apoptotic process Source: Ensembl
  7. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  8. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  9. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  10. protein stabilization Source: Ensembl
  11. response to misfolded protein Source: Ensembl
  12. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClusterinUniRule annotation
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. mitochondrion Source: Ensembl
  3. perinuclear region of cytoplasm Source: Ensembl
  4. spherical high-density lipoprotein particle Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 PredictedImported
Add
BLAST
Chaini18 – 448431 PredictedImported
PRO_5000057055Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ549A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the clusterin family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
InParanoidiQ549A5.
KOiK17252.
OMAiKFYARVC.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q549A5-1 [UniParc]FASTAAdd to Basket

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MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ    50
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV 100
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY 150
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH 200
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI 250
HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ 300
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK 350
MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR 400
VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE 448
Length:448
Mass (Da):51,656
Last modified:May 24, 2005 - v1
Checksum:iA860600A6F8D47F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.1.
UniGeneiMm.200608.

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1 .
AF248057 mRNA. Translation: AAF67184.1 .
RefSeqi NP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.1.
UniGenei Mm.200608.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12759.
KEGGi mmu:12759.

Organism-specific databases

CTDi 1191.
MGIi MGI:88423. Clu.

Phylogenomic databases

GeneTreei ENSGT00530000063668.
HOVERGENi HBG006908.
InParanoidi Q549A5.
KOi K17252.
OMAi KFYARVC.

Miscellaneous databases

ChiTaRSi CLU. mouse.
NextBioi 282108.
SOURCEi Search...

Gene expression databases

Genevestigatori Q549A5.

Family and domain databases

InterProi IPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view ]
PANTHERi PTHR10970:SF1. PTHR10970:SF1. 1 hit.
Pfami PF01093. Clusterin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002368. Clusterin. 1 hit.
SMARTi SM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view ]
PROSITEi PS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
    Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
    (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  2. Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  4. "Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
    You K.H., Jeon J.H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Balb/cImported.
    Tissue: UterusImported.

Entry informationi

Entry nameiQ549A5_MOUSE
AccessioniPrimary (citable) accession number: Q549A5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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