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Q549A5

- Q549A5_MOUSE

UniProt

Q549A5 - Q549A5_MOUSE

Protein

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. chaperone-mediated protein folding Source: Ensembl
    2. intrinsic apoptotic signaling pathway Source: Ensembl
    3. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    4. negative regulation of protein homooligomerization Source: Ensembl
    5. positive regulation of apoptotic process Source: Ensembl
    6. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    7. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    8. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    9. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    10. protein stabilization Source: Ensembl
    11. response to misfolded protein Source: Ensembl
    12. response to virus Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ClusterinUniRule annotation
    Gene namesi
    Name:CluImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88423. Clu.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. mitochondrion Source: Ensembl
    3. perinuclear region of cytoplasm Source: Ensembl
    4. spherical high-density lipoprotein particle Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717 PotentialImportedAdd
    BLAST
    Chaini18 – 448431 PotentialImportedPRO_5000057055Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ549A5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the clusterin family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    GeneTreeiENSGT00530000063668.
    HOVERGENiHBG006908.
    InParanoidiQ549A5.
    KOiK17252.
    OMAiKFYARVC.

    Family and domain databases

    InterProiIPR016016. Clusterin.
    IPR000753. Clusterin-like.
    IPR016015. Clusterin_C.
    IPR016014. Clusterin_N.
    [Graphical view]
    PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
    PfamiPF01093. Clusterin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002368. Clusterin. 1 hit.
    SMARTiSM00035. CLa. 1 hit.
    SM00030. CLb. 1 hit.
    [Graphical view]
    PROSITEiPS00492. CLUSTERIN_1. 1 hit.
    PS00493. CLUSTERIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q549A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ    50
    GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV 100
    CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY 150
    FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH 200
    DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI 250
    HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ 300
    CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK 350
    MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR 400
    VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE 448
    Length:448
    Mass (Da):51,656
    Last modified:May 24, 2005 - v1
    Checksum:iA860600A6F8D47F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182509 Genomic DNA. Translation: AAF06365.1.
    AF248057 mRNA. Translation: AAF67184.1.
    RefSeqiNP_038520.2. NM_013492.2.
    XP_006518567.1. XM_006518504.1.
    UniGeneiMm.200608.

    Genome annotation databases

    GeneIDi12759.
    KEGGimmu:12759.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182509 Genomic DNA. Translation: AAF06365.1 .
    AF248057 mRNA. Translation: AAF67184.1 .
    RefSeqi NP_038520.2. NM_013492.2.
    XP_006518567.1. XM_006518504.1.
    UniGenei Mm.200608.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12759.
    KEGGi mmu:12759.

    Organism-specific databases

    CTDi 1191.
    MGIi MGI:88423. Clu.

    Phylogenomic databases

    GeneTreei ENSGT00530000063668.
    HOVERGENi HBG006908.
    InParanoidi Q549A5.
    KOi K17252.
    OMAi KFYARVC.

    Miscellaneous databases

    ChiTaRSi CLU. mouse.
    NextBioi 282108.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q549A5.

    Family and domain databases

    InterProi IPR016016. Clusterin.
    IPR000753. Clusterin-like.
    IPR016015. Clusterin_C.
    IPR016014. Clusterin_N.
    [Graphical view ]
    PANTHERi PTHR10970:SF1. PTHR10970:SF1. 1 hit.
    Pfami PF01093. Clusterin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002368. Clusterin. 1 hit.
    SMARTi SM00035. CLa. 1 hit.
    SM00030. CLb. 1 hit.
    [Graphical view ]
    PROSITEi PS00492. CLUSTERIN_1. 1 hit.
    PS00493. CLUSTERIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
      Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
      (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SvJ/129Imported.
    2. Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SvJ/129Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: SvJ/129Imported.
    4. "Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
      You K.H., Jeon J.H.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Balb/cImported.
      Tissue: UterusImported.

    Entry informationi

    Entry nameiQ549A5_MOUSE
    AccessioniPrimary (citable) accession number: Q549A5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)