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Q549A5 (Q549A5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Clusterin RuleBase RU000629
Gene names
Name:Clu MGI 88423
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the clusterin family. RuleBase RU000629

Ontologies

Keywords
   DomainSignal EMBL AAF06365.1
Gene Ontology (GO)
   Biological_processchaperone-mediated protein folding

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of intrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: Ensembl

protein stabilization

Inferred from electronic annotation. Source: Ensembl

response to misfolded protein

Inferred from electronic annotation. Source: Ensembl

response to virus

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from electronic annotation. Source: Ensembl

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

spherical high-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 23055941. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential EMBL AAF06365.1
Chain18 – 448431 Potential EMBL AAF06365.1
PRO_5000057055

Sequences

Sequence LengthMass (Da)Tools
Q549A5 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: A860600A6F8D47F6

FASTA44851,656
        10         20         30         40         50         60 
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ GVKHIKTLIE 

        70         80         90        100        110        120 
KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC 

       130        140        150        160        170        180 
MKFYARVCRS GSGLVGQQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA 

       190        200        210        220        230        240 
RASGIIDTLF QDRFFARELH DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH 

       250        260        270        280        290        300 
NMFQPFFEMI HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ 

       310        320        330        340        350        360 
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK MLNTSSLLEQ 

       370        380        390        400        410        420 
LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR VTEVVVKLFD SDPITVVLPE 

       430        440 
EVSKDNPKFM DTVAEKALQE YRRKSRAE 

« Hide

References

[1]"Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
(In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SvJ/129 EMBL AAF06365.1.
[2]Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SvJ/129 EMBL AAF06365.1.
[3]"Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis."
McLaughlin L., Zhu G., Mistry M., Ley-Ebert C., Stuart W.D., Florio C.J., Groen P.A., Witt S.A., Kimball T.R., Witte D.P., Harmony J.A., Aronow B.J.
J. Clin. Invest. 106:1105-1113(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SvJ/129 EMBL AAF06365.1.
[4]"Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
You K.H., Jeon J.H.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Balb/c EMBL AAF67184.1.
Tissue: Uterus EMBL AAF67184.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.1.
UniGeneMm.200608.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12759.
KEGGmmu:12759.

Organism-specific databases

CTD1191.
MGIMGI:88423. Clu.

Phylogenomic databases

GeneTreeENSGT00530000063668.
HOVERGENHBG006908.
InParanoidQ549A5.
KOK17252.
OMAKFYARVC.

Gene expression databases

GenevestigatorQ549A5.

Family and domain databases

InterProIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFPIRSF002368. Clusterin. 1 hit.
SMARTSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCLU. mouse.
NextBio282108.
SOURCESearch...

Entry information

Entry nameQ549A5_MOUSE
AccessionPrimary (citable) accession number: Q549A5
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)