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Protein

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
ClusterinUniRule annotation
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_501102388222 – 448ClusterinUniRule annotationAdd BLAST427

Proteomic databases

MaxQBiQ549A5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022037.

Interactioni

Subunit structurei

Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ549A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 226CLbInterPro annotationAdd BLAST205
Domaini227 – 442CLaInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili59 – 93Sequence analysisAdd BLAST35
Coiled coili319 – 364Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the clusterin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IHRB. Eukaryota.
ENOG410YYKB. LUCA.
HOVERGENiHBG006908.
KOiK17252.
OMAiMKFYARV.
OrthoDBiEOG091G05R5.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR033986. Clusterin_CS.
IPR016014. Clusterin_N.
PANTHERiPTHR10970. PTHR10970. 1 hit.
PTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiView protein in Pfam
PF01093. Clusterin. 1 hit.
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiView protein in SMART
SM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
PROSITEiView protein in PROSITE
PS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q549A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70 80 90 100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV
110 120 130 140 150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY
160 170 180 190 200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH
210 220 230 240 250
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI
260 270 280 290 300
HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ
310 320 330 340 350
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK
360 370 380 390 400
MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR
410 420 430 440
VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE
Length:448
Mass (Da):51,656
Last modified:May 24, 2005 - v1
Checksum:iA860600A6F8D47F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.3.
XP_006518567.1. XM_006518504.3.
UniGeneiMm.200608.

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Similar proteinsi

Entry informationi

Entry nameiQ549A5_MOUSE
AccessioniPrimary (citable) accession number: Q549A5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)