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Q549A5

- Q549A5_MOUSE

UniProt

Q549A5 - Q549A5_MOUSE

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Protein

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cell morphogenesis Source: Ensembl
  2. central nervous system myelin maintenance Source: Ensembl
  3. chaperone-mediated protein complex assembly Source: Ensembl
  4. chaperone-mediated protein folding Source: Ensembl
  5. intrinsic apoptotic signaling pathway Source: Ensembl
  6. microglial cell activation Source: Ensembl
  7. microglial cell proliferation Source: Ensembl
  8. negative regulation of beta-amyloid formation Source: Ensembl
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  10. negative regulation of protein homooligomerization Source: Ensembl
  11. positive regulation of apoptotic process Source: Ensembl
  12. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  13. positive regulation of neurofibrillary tangle assembly Source: Ensembl
  14. positive regulation of neuron death Source: Ensembl
  15. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  16. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  17. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  18. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  19. positive regulation of tau-protein kinase activity Source: Ensembl
  20. positive regulation of tumor necrosis factor production Source: Ensembl
  21. protein import Source: Ensembl
  22. protein stabilization Source: Ensembl
  23. regulation of beta-amyloid clearance Source: Ensembl
  24. regulation of neuronal signal transduction Source: Ensembl
  25. response to misfolded protein Source: Ensembl
  26. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ClusterinUniRule annotation
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: Ensembl
  2. blood microparticle Source: Ensembl
  3. extracellular matrix Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. mitochondrion Source: Ensembl
  6. neurofibrillary tangle Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. spherical high-density lipoprotein particle Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 PotentialImportedAdd
BLAST
Chaini18 – 448431 PotentialImportedPRO_5000057055Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ549A5.

Family & Domainsi

Sequence similaritiesi

Belongs to the clusterin family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

GeneTreeiENSGT00530000063668.
HOVERGENiHBG006908.
KOiK17252.
OMAiKFYARVC.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
PIRSFiPIRSF002368. Clusterin. 1 hit.
SMARTiSM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q549A5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70 80 90 100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV
110 120 130 140 150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY
160 170 180 190 200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH
210 220 230 240 250
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI
260 270 280 290 300
HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ
310 320 330 340 350
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK
360 370 380 390 400
MLNTSSLLEQ LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR
410 420 430 440
VTEVVVKLFD SDPITVVLPE EVSKDNPKFM DTVAEKALQE YRRKSRAE
Length:448
Mass (Da):51,656
Last modified:May 24, 2005 - v1
Checksum:iA860600A6F8D47F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1.
AF248057 mRNA. Translation: AAF67184.1.
RefSeqiNP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.1.
UniGeneiMm.200608.

Genome annotation databases

GeneIDi12759.
KEGGimmu:12759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182509 Genomic DNA. Translation: AAF06365.1 .
AF248057 mRNA. Translation: AAF67184.1 .
RefSeqi NP_038520.2. NM_013492.2.
XP_006518567.1. XM_006518504.1.
UniGenei Mm.200608.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12759.
KEGGi mmu:12759.

Organism-specific databases

CTDi 1191.
MGIi MGI:88423. Clu.

Phylogenomic databases

GeneTreei ENSGT00530000063668.
HOVERGENi HBG006908.
KOi K17252.
OMAi KFYARVC.

Miscellaneous databases

ChiTaRSi Clu. mouse.
NextBioi 282108.
SOURCEi Search...

Gene expression databases

Genevestigatori Q549A5.

Family and domain databases

InterProi IPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016015. Clusterin_C.
IPR016014. Clusterin_N.
[Graphical view ]
PANTHERi PTHR10970:SF1. PTHR10970:SF1. 1 hit.
Pfami PF01093. Clusterin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002368. Clusterin. 1 hit.
SMARTi SM00035. CLa. 1 hit.
SM00030. CLb. 1 hit.
[Graphical view ]
PROSITEi PS00492. CLUSTERIN_1. 1 hit.
PS00493. CLUSTERIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Clusterin Gene Locus Structure and Function in Development, Homeostasis, and Tissue Injury."
    Zhu G., Ley-Ebert C., Barrie A.M. III, Witte D.P., Rosenberg M., Harmony J.A.K., Aronow B.J.
    (In) Landes R.G. (eds.); CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION., pp.1-16, Springer-Verlag, Austin, TX (1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  2. Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K., Aronow B.J.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SvJ/129Imported.
  4. "Identification of Truncated SGP-2 Lacking a Signal Peptide for Secretion."
    You K.H., Jeon J.H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Balb/cImported.
    Tissue: UterusImported.

Entry informationi

Entry nameiQ549A5_MOUSE
AccessioniPrimary (citable) accession number: Q549A5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)