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Protein

C-X-C motif chemokine

Gene

Cxcl10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokineUniRule annotation
Gene namesi
Name:Cxcl10Imported
Synonyms:Scyb10Imported
ORF Names:mCG_12531Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352450. Cxcl10.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Chaini22 – 9877C-X-C motif chemokineUniRule annotationPRO_5007364826Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 8963SCYInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the intercrine alpha (chemokine CxC) family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOVERGENiHBG107789.
KOiK12671.
OMAiRCTCIKI.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF47. PTHR10179:SF47. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q548V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI
60 70 80 90
IPASLSCPRV EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP
Length:98
Mass (Da):10,789
Last modified:May 24, 2005 - v1
Checksum:i42B0E6A0CC56FE36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122365 Genomic DNA. No translation available.
AF227743 mRNA. Translation: AAG10400.1.
AK144279 mRNA. Translation: BAE25810.1.
AK150765 mRNA. Translation: BAE29832.1.
AK151210 mRNA. Translation: BAE30205.1.
AK151415 mRNA. Translation: BAE30380.1.
AK151534 mRNA. Translation: BAE30481.1.
AK152568 mRNA. Translation: BAE31320.1.
AK152814 mRNA. Translation: BAE31517.1.
AK153181 mRNA. Translation: BAE31783.1.
AK157130 mRNA. Translation: BAE33973.1.
AK157139 mRNA. Translation: BAE33975.1.
AK157589 mRNA. Translation: BAE34130.1.
AK157678 mRNA. Translation: BAE34149.1.
AK172540 mRNA. Translation: BAE43058.1.
CH466617 Genomic DNA. Translation: EDL05256.1.
RefSeqiNP_067249.1. NM_021274.2.
UniGeneiMm.877.

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
GeneIDi15945.
KEGGimmu:15945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122365 Genomic DNA. No translation available.
AF227743 mRNA. Translation: AAG10400.1.
AK144279 mRNA. Translation: BAE25810.1.
AK150765 mRNA. Translation: BAE29832.1.
AK151210 mRNA. Translation: BAE30205.1.
AK151415 mRNA. Translation: BAE30380.1.
AK151534 mRNA. Translation: BAE30481.1.
AK152568 mRNA. Translation: BAE31320.1.
AK152814 mRNA. Translation: BAE31517.1.
AK153181 mRNA. Translation: BAE31783.1.
AK157130 mRNA. Translation: BAE33973.1.
AK157139 mRNA. Translation: BAE33975.1.
AK157589 mRNA. Translation: BAE34130.1.
AK157678 mRNA. Translation: BAE34149.1.
AK172540 mRNA. Translation: BAE43058.1.
CH466617 Genomic DNA. Translation: EDL05256.1.
RefSeqiNP_067249.1. NM_021274.2.
UniGeneiMm.877.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855.
GeneIDi15945.
KEGGimmu:15945.

Organism-specific databases

CTDi3627.
MGIiMGI:1352450. Cxcl10.

Phylogenomic databases

eggNOGiENOG410J1VC. Eukaryota.
ENOG410ZTJK. LUCA.
GeneTreeiENSGT00530000063958.
HOVERGENiHBG107789.
KOiK12671.
OMAiRCTCIKI.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF47. PTHR10179:SF47. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  4. "Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression."
    Fischer F.R., Santambrogio L., Luo Y., Berman M.A., Hancock W.W., Dorf M.E.
    J. Neuroimmunol. 110:195-208(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SJL/JImported.
    Tissue: Spinal cordImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
    Tissue: Activated spleenImported.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: Activated spleenImported, Bone marrowImported and Jejunal and colic lymph nodeImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  14. Ensembl
    Submitted (AUG-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ548V9_MOUSE
AccessioniPrimary (citable) accession number: Q548V9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.