ID   Q548Q7_MOUSE            Unreviewed;       198 AA.
AC   Q548Q7;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   24-JAN-2024, entry version 172.
DE   RecName: Full=Suppressor of cytokine signaling 2 {ECO:0000256|ARBA:ARBA00021409};
GN   Name=Socs2 {ECO:0000313|EMBL:AAI06154.1, ECO:0000313|MGI:MGI:1201787};
GN   Synonyms=Cish2 {ECO:0000313|EMBL:AAL76097.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL76097.1};
RN   [1] {ECO:0000313|EMBL:AAL76097.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv {ECO:0000313|EMBL:AAN84618.1};
RX   PubMed=9806843; DOI=10.1006/geno.1998.5540;
RA   Horvat S., Medrano J.F.;
RT   "A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse
RT   chromosome 10 and identification of the murine Raidd/Cradd gene in the
RT   candidate region.";
RL   Genomics 54:159-164(1998).
RN   [2] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [3] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [4] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [5] {ECO:0000313|EMBL:AAL76097.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wong M.L., Islas-Trejo A., Medrano J.F.;
RT   "Sequence analysis of the mouse high growth (hg) deletion and discovery of
RT   a novel fusion gene between Socs-2 and Plexin C1.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AAL76097.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv {ECO:0000313|EMBL:AAN84618.1};
RX   PubMed=11401434; DOI=10.1006/geno.2000.6441;
RA   Horvat S., Medrano J.F.;
RT   "Lack of Socs2 expression causes the high-growth phenotype in mice.";
RL   Genomics 72:209-212(2001).
RN   [7] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [8] {ECO:0000313|EMBL:AAN84618.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv {ECO:0000313|EMBL:AAN84618.1};
RX   PubMed=12459263; DOI=10.1016/S0378-1119(02)01052-1;
RA   Wong M.L., Islas-Trejo A., Medrano J.F.;
RT   "Structural characterization of the mouse high growth deletion and
RT   discovery of a novel fusion transcript between suppressor of cytokine
RT   signaling-2 (Socs-2) and viral encoded semaphorin receptor (Plexin C1).";
RL   Gene 299:153-163(2002).
RN   [9] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [10] {ECO:0000313|EMBL:AAI06154.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N {ECO:0000313|EMBL:AAI06154.1};
RC   TISSUE=Colon {ECO:0000313|EMBL:AAI06154.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11] {ECO:0000313|EMBL:BAE35854.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA   Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA   Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA   Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA   Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [13] {ECO:0000313|EMBL:BAE23343.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE23343.1};
RC   TISSUE=Cerebellum {ECO:0000313|EMBL:BAE23343.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; BC106153; AAI06154.1; -; mRNA.
DR   EMBL; AF292933; AAL76097.1; -; Genomic_DNA.
DR   EMBL; AE016773; AAN84618.1; -; Genomic_DNA.
DR   EMBL; AK137403; BAE23343.1; -; mRNA.
DR   EMBL; AK160537; BAE35854.1; -; mRNA.
DR   EMBL; AK162591; BAE36978.1; -; mRNA.
DR   RefSeq; NP_001162126.1; NM_001168655.1.
DR   RefSeq; NP_001162127.1; NM_001168656.1.
DR   RefSeq; NP_001162128.1; NM_001168657.1.
DR   RefSeq; NP_031732.1; NM_007706.4.
DR   RefSeq; XP_011241712.1; XM_011243410.2.
DR   AlphaFoldDB; Q548Q7; -.
DR   SMR; Q548Q7; -.
DR   MaxQB; Q548Q7; -.
DR   Antibodypedia; 4158; 343 antibodies from 37 providers.
DR   DNASU; 216233; -.
DR   GeneID; 216233; -.
DR   KEGG; mmu:216233; -.
DR   AGR; MGI:1201787; -.
DR   CTD; 8835; -.
DR   MGI; MGI:1201787; Socs2.
DR   VEuPathDB; HostDB:ENSMUSG00000020027; -.
DR   HOGENOM; CLU_079452_4_0_1; -.
DR   OMA; LRKTGWY; -.
DR   OrthoDB; 5362214at2759; -.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 216233; 1 hit in 75 CRISPR screens.
DR   ChiTaRS; Socs2; mouse.
DR   ExpressionAtlas; Q548Q7; baseline and differential.
DR   GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
DR   GO; GO:0060396; P:growth hormone receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   CDD; cd10383; SH2_SOCS2; 1.
DR   CDD; cd03736; SOCS_SOCS2; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.750.20; SOCS box; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035862; SOCS2_SH2.
DR   InterPro; IPR028410; SOCS2_SOCS_box.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF7; SUPPRESSOR OF CYTOKINE SIGNALING 2; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          48..156
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          151..197
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  22434 MW;  C9051AE9C84BA7F5 CRC64;
     MTLRCLEPSG NGADRTRSQW GTAGLPEEQS PEAARLAKAL RELSQTGWYW GSMTVNEAKE
     KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD
     SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL YLTKPLYTSA PTLQHFCRLA INKCTGTIWG
     LPLPTRLKDY LEEYKFQV
//