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Q548Q7

- Q548Q7_MOUSE

UniProt

Q548Q7 - Q548Q7_MOUSE

Protein
Submitted name:

MCG4302, isoform CRA_c

Gene

Socs2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Pathwayi

    GO - Molecular functioni

    1. growth hormone receptor binding Source: MGI

    GO - Biological processi

    1. intracellular signal transduction Source: MGI
    2. lactation Source: MGI
    3. mammary gland alveolus development Source: MGI
    4. negative regulation of JAK-STAT cascade Source: MGI
    5. negative regulation of multicellular organism growth Source: MGI
    6. positive regulation of neuron differentiation Source: MGI
    7. protein ubiquitination Source: UniProtKB-UniPathway
    8. regulation of cell growth Source: InterPro
    9. regulation of multicellular organism growth Source: MGI

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MCG4302, isoform CRA_cImported
    Submitted name:
    Suppressor of cytokine signaling 2Imported
    Submitted name:
    Suppressor of cytokine signaling SOCS2Imported
    Submitted name:
    Suppressor of cytokine signaling-2Imported
    Gene namesi
    Name:Socs2Imported
    Synonyms:Cish2Imported
    ORF Names:mCG_4302Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1201787. Socs2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Expressioni

    Gene expression databases

    GenevestigatoriQ548Q7.

    Family & Domainsi

    Sequence similaritiesi

    Contains SOCS box domain.SAAS annotation

    Phylogenomic databases

    eggNOGiNOG320153.
    GeneTreeiENSGT00740000115151.
    HOVERGENiHBG002457.
    InParanoidiQ548Q7.
    KOiK04695.
    OMAiWELPLPT.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR028413. SOCS.
    IPR028410. SOCS2.
    IPR001496. SOCS_C.
    [Graphical view]
    PANTHERiPTHR10385. PTHR10385. 1 hit.
    PTHR10385:SF27. PTHR10385:SF27. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00253. SOCS. 1 hit.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q548Q7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLRCLEPSG NGADRTRSQW GTAGLPEEQS PEAARLAKAL RELSQTGWYW    50
    GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ 100
    DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL 150
    YLTKPLYTSA PTLQHFCRLA INKCTGTIWG LPLPTRLKDY LEEYKFQV 198
    Length:198
    Mass (Da):22,434
    Last modified:May 24, 2005 - v1
    Checksum:iC9051AE9C84BA7F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC106153 mRNA. Translation: AAI06154.1.
    AF292933 Genomic DNA. Translation: AAL76097.1.
    AE016773 Genomic DNA. Translation: AAN84618.1.
    AK137403 mRNA. Translation: BAE23343.1.
    AK160537 mRNA. Translation: BAE35854.1.
    AK162591 mRNA. Translation: BAE36978.1.
    CH466539 Genomic DNA. Translation: EDL21600.1.
    CH466539 Genomic DNA. Translation: EDL21602.1.
    CH466539 Genomic DNA. Translation: EDL21603.1.
    RefSeqiNP_001162126.1. NM_001168655.1.
    NP_001162127.1. NM_001168656.1.
    NP_001162128.1. NM_001168657.1.
    NP_031732.1. NM_007706.4.
    UniGeneiMm.474283.
    Mm.490329.

    Genome annotation databases

    GeneIDi216233.
    KEGGimmu:216233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC106153 mRNA. Translation: AAI06154.1 .
    AF292933 Genomic DNA. Translation: AAL76097.1 .
    AE016773 Genomic DNA. Translation: AAN84618.1 .
    AK137403 mRNA. Translation: BAE23343.1 .
    AK160537 mRNA. Translation: BAE35854.1 .
    AK162591 mRNA. Translation: BAE36978.1 .
    CH466539 Genomic DNA. Translation: EDL21600.1 .
    CH466539 Genomic DNA. Translation: EDL21602.1 .
    CH466539 Genomic DNA. Translation: EDL21603.1 .
    RefSeqi NP_001162126.1. NM_001168655.1.
    NP_001162127.1. NM_001168656.1.
    NP_001162128.1. NM_001168657.1.
    NP_031732.1. NM_007706.4.
    UniGenei Mm.474283.
    Mm.490329.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 216233.
    KEGGi mmu:216233.

    Organism-specific databases

    CTDi 8835.
    MGIi MGI:1201787. Socs2.

    Phylogenomic databases

    eggNOGi NOG320153.
    GeneTreei ENSGT00740000115151.
    HOVERGENi HBG002457.
    InParanoidi Q548Q7.
    KOi K04695.
    OMAi WELPLPT.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi SOCS2. mouse.
    NextBioi 375089.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q548Q7.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR028413. SOCS.
    IPR028410. SOCS2.
    IPR001496. SOCS_C.
    [Graphical view ]
    PANTHERi PTHR10385. PTHR10385. 1 hit.
    PTHR10385:SF27. PTHR10385:SF27. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00253. SOCS. 1 hit.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region."
      Horvat S., Medrano J.F.
      Genomics 54:159-164(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    2. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    5. "Sequence analysis of the mouse high growth (hg) deletion and discovery of a novel fusion gene between Socs-2 and Plexin C1."
      Wong M.L., Islas-Trejo A., Medrano J.F.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Lack of Socs2 expression causes the high-growth phenotype in mice."
      Horvat S., Medrano J.F.
      Genomics 72:209-212(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    7. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    8. "Structural characterization of the mouse high growth deletion and discovery of a novel fusion transcript between suppressor of cytokine signaling-2 (Socs-2) and viral encoded semaphorin receptor (Plexin C1)."
      Wong M.L., Islas-Trejo A., Medrano J.F.
      Gene 299:153-163(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    9. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    10. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: ColonImported.
    12. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    13. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    14. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    15. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: CerebellumImported.
    16. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ548Q7_MOUSE
    AccessioniPrimary (citable) accession number: Q548Q7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)