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Protein

Vacuolar protein sorting-associated protein 28 homolog

Gene

VPS28

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.UniRule annotation

GO - Biological processi

Keywordsi

Biological processProtein transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 28 homologUniRule annotation
Gene namesi
Name:VPS28Imported
ORF Names:hCG_24005Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000160948.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

EndosomeUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38512.

Expressioni

Gene expression databases

BgeeiENSG00000160948.

Interactioni

Protein-protein interaction databases

IntActiQ548N1. 18 interactors.

Structurei

3D structure databases

SMRiQ548N1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 120VPS28 N-terminalInterPro annotationAdd BLAST108
Domaini124 – 220VPS28 C-terminalInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the VPS28 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3284. Eukaryota.
ENOG4111IQ4. LUCA.
HOVERGENiHBG054248.
KOiK12184.
OMAiKYRLDCP.

Family and domain databases

InterProiView protein in InterPro
IPR037202. ESCRT_assembly_dom.
IPR007143. VPS28.
IPR017899. VPS28_C.
IPR037206. VPS28_C_sf.
IPR017898. VPS28_N.
PANTHERiPTHR12937. PTHR12937. 1 hit.
PfamiView protein in Pfam
PF03997. VPS28. 1 hit.
PIRSFiPIRSF017535. VPS28. 1 hit.
SUPFAMiSSF140111. SSF140111. 1 hit.
SSF140427. SSF140427. 1 hit.
PROSITEiView protein in PROSITE
PS51310. VPS28_C. 1 hit.
PS51313. VPS28_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q548N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHGIPATPG IGAPGNKPEL YEEVKLYKNA REREKYDNMA ELFAVVKTMQ
60 70 80 90 100
ALEKAYIKDC VSPSEYTAAC SRLLVQYKAA FRQVQGSEIS SIDEFCRKFR
110 120 130 140 150
LDCPLAMERI KEDRPITIKD DKGNLNRCIA DVVSLFITVM DKLRLEIRAM
160 170 180 190 200
DEIQPDLREL METMHRMSHL PPDFEGRQTV SQWLQTLSGM SASDELDDSQ
210 220
VRQMLFDLES AYNAFNRFLH A
Length:221
Mass (Da):25,425
Last modified:May 24, 2005 - v1
Checksum:iB2E1697B82D02AB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei221Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316887 mRNA. Translation: AAK00314.1.
KU178635 mRNA. Translation: ALQ34093.1.
CH471162 Genomic DNA. Translation: EAW82094.1.
CH471162 Genomic DNA. Translation: EAW82100.1.
RefSeqiNP_057292.1. NM_016208.3.
UniGeneiHs.418175.
Hs.650693.

Genome annotation databases

GeneIDi51160.
KEGGihsa:51160.

Similar proteinsi

Entry informationi

Entry nameiQ548N1_HUMAN
AccessioniPrimary (citable) accession number: Q548N1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.