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Protein
Submitted name:

Glutamate decarboxylase

Gene

Gad2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate decarboxylaseImported (EC:4.1.1.15Imported)
Submitted name:
Glutamic acid decarboxylase 2Imported
Gene namesi
Name:Gad2Imported
Synonyms:gad65Imported
ORF Names:mCG_15161Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95634. Gad2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei396N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

MaxQBiQ548L4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026787.
ExpressionAtlasiQ548L4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028123.

Structurei

3D structure databases

ProteinModelPortaliQ548L4.
SMRiQ548L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
HOVERGENiHBG004980.
KOiK01580.
OMAiWRAKGTT.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ548L4.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q548L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPGSGFWS FGSEDGSADP ENPGTARAWC QVAQKFTGGI GNKLCALLYG
60 70 80 90 100
DSGKPAEGGG SVTSRAATGK VACTCDQKPC NCPKGDVNYA FLHATDLLPA
110 120 130 140 150
CDGERPTLAF LQDVMNILLQ YVVKSFDRST KVIDFHYPNE LLQEYNWELA
160 170 180 190 200
DQPQNLEEIL THCQTTLKYA IKTGHPRYFN QLSTGLDMVG LAADWLTSTA
210 220 230 240 250
NTNMFTYEIA PVFVLLEYVT LKKMREIIGW PGGSGDGIFS PGGAISNMYA
260 270 280 290 300
MLIARYKMFP EVKEKGMAAV PRLIAFTSEH SHFSLKKGAA ALGIGTDSVI
310 320 330 340 350
LIKCDERGKM IPSDLERRIL EVKQKGFVPF LVSATAGTTV YGAFDPLLAV
360 370 380 390 400
ADICKKYKIW MHVDAAWGGG LLMSRKHKWK LSGVERANSV TWNPHKMMGV
410 420 430 440 450
PLQCSALLVR EEGLMQSCNQ MHASYLFQQD KHYDLSYDTG DKALQCGRHV
460 470 480 490 500
DVFKLWLMWR AKGTTGFEAH IDKCLELAEY LYTIIKNREG YEMVFDGKPQ
510 520 530 540 550
HTNVCFWFVP PSLRTLEDNE ERMSRLSKVA PVIKARMMEY GTTMVSYQPL
560 570 580
GDKVNFFRMV ISNPAATHQD IDFLIEEIER LGQDL
Length:585
Mass (Da):65,224
Last modified:May 24, 2005 - v1
Checksum:iC2F486E85123B057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326549 mRNA. Translation: AAL37395.1.
AF326550 mRNA. Translation: AAL37396.1.
KC134211 mRNA. Translation: AFX68721.1.
CH466542 Genomic DNA. Translation: EDL08136.1.
RefSeqiNP_032104.2. NM_008078.2.
UniGeneiMm.4784.

Genome annotation databases

GeneIDi14417.
KEGGimmu:14417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326549 mRNA. Translation: AAL37395.1.
AF326550 mRNA. Translation: AAL37396.1.
KC134211 mRNA. Translation: AFX68721.1.
CH466542 Genomic DNA. Translation: EDL08136.1.
RefSeqiNP_032104.2. NM_008078.2.
UniGeneiMm.4784.

3D structure databases

ProteinModelPortaliQ548L4.
SMRiQ548L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028123.

Proteomic databases

MaxQBiQ548L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14417.
KEGGimmu:14417.

Organism-specific databases

CTDi2572.
MGIiMGI:95634. Gad2.

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
HOVERGENiHBG004980.
KOiK01580.
OMAiWRAKGTT.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ548L4.

Miscellaneous databases

ChiTaRSiGad2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026787.
ExpressionAtlasiQ548L4. baseline and differential.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ548L4_MOUSE
AccessioniPrimary (citable) accession number: Q548L4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 12, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.