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Q54869

- SYR_STRPN

UniProt

Q54869 - SYR_STRPN

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-2139-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:SP_2078
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Arginine--tRNA ligasePRO_0000151618Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
gatCQ97SE52EBI-2207421,EBI-2207053
groSQ97NV32EBI-2207421,EBI-2206949

Protein-protein interaction databases

IntActiQ54869. 2 interactions.
STRINGi170187.SP_2078.

Structurei

3D structure databases

ProteinModelPortaliQ54869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi121 – 13111"HIGH" regionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
KOiK01887.
OMAiYVKFHDE.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54869-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTKELIASE LSSIIDSLDQ EAILKLLETP KNSEMGDIAF PAFSLAKVER
60 70 80 90 100
KAPQMIAAEL AEKMNSQAFE KVVATGPYVN FFLDKSAISA QVLQAVTTEK
110 120 130 140 150
EHYADQNIGK QENVVIDMSS PNIAKPFSIG HLRSTVIGDS LSHIFQKIGY
160 170 180 190 200
QTVKVNHLGD WGKQFGMLIV AYKKWGDEEA VKAHPIDELL KLYVRINAEA
210 220 230 240 250
ENDPSLDEEA REWFRKLENG DEEALALWQW FRDESLVEFN RLYNELKVEF
260 270 280 290 300
DSYNGEAFYN DKMDAVVDIL SEKGLLLESE GAQVVNLEKY GIEHPALIKK
310 320 330 340 350
SDGATLYITR DLAAALYRKN EYQFAKSIYV VGQEQSAHFK QLKAVLQEMG
360 370 380 390 400
YDWSDDITHV PFGLVTKEGK KLSTRKGNVI LLEPTVAEAV SRAKVQIEAK
410 420 430 440 450
NPELENKDQV AHAVGIGAIK FYDLKTDRTN GYDFDLEAMV SFEGETGPYV
460 470 480 490 500
QYAYARIQSI LRKADFKPET AGNYSLNDTE SWEIIKLIQD FPRIINRAAD
510 520 530 540 550
NFEPSIIAKF AISLAQSFNK YYAHTRILDE SPERDSRLAL SYATAVVLKE
560
ALRLLGVEAP EKM
Length:563
Mass (Da):63,472
Last modified:September 26, 2001 - v2
Checksum:i1FA1E992B1E92D53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK76139.1.
M18729 Genomic DNA. Translation: AAA88595.1.
PIRiB95243.
RefSeqiNP_346499.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK76139; AAK76139; SP_2078.
GeneIDi931968.
KEGGispn:SP_2078.
PATRICi19708743. VBIStrPne105772_2162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK76139.1 .
M18729 Genomic DNA. Translation: AAA88595.1 .
PIRi B95243.
RefSeqi NP_346499.1. NC_003028.3.

3D structure databases

ProteinModelPortali Q54869.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q54869. 2 interactions.
STRINGi 170187.SP_2078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK76139 ; AAK76139 ; SP_2078 .
GeneIDi 931968.
KEGGi spn:SP_2078.
PATRICi 19708743. VBIStrPne105772_2162.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247211.
KOi K01887.
OMAi YVKFHDE.
OrthoDBi EOG6JB13C.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-2139-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.
  2. "Nucleotide sequence of the hexA gene for DNA mismatch repair in Streptococcus pneumoniae and homology of hexA to mutS of Escherichia coli and Salmonella typhimurium."
    Priebe S.D., Hadi S.M., Greenberg B., Lacks S.A.
    J. Bacteriol. 170:190-196(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-109.
    Strain: 175.

Entry informationi

Entry nameiSYR_STRPN
AccessioniPrimary (citable) accession number: Q54869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3