Reviewed, UniProtKB/Swiss-Prot Q54800 (CAP3C_STRPN)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	cap3C
Synonyms:	cps3U

Organism

Streptococcus pneumoniae

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism. Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000201365
Experimental info
	Sequence conflict	204	1	N → H in AAC43313. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q54800-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F8E243D00F47EEA8	FASTA	306	33,919
	10 20 30 40 50 60 MKKVKKAVIP AAGLGTRFLP ATKALAKEML PIVDRPTIHF VIEEALRSGI EDILVVTGKS 70 80 90 100 110 120 KRSIEDYFDS TFELEYSLRK QGKMELLKSV NESTDIKVHF VRQSSPRGLG DAVLQAKSFV 130 140 150 160 170 180 GDDPFVVMLG DDLMDITDST AVPLTRQLMD DYNATQASTI AVMPVRYEDV SSYGVISPRL 190 200 210 220 230 240 ESSNGLYSVD AFVEKPKPEE APSNLAIIGR YLLTPEIFSI LETQKPGAGN EIQLTDAIDT 250 260 270 280 290 300 LNKTQSVFAR EFVGKRYDVG DKFNFMKTSI DYALQHPQIK ESLKNYVIAL GKQLEKLDDC SSSGHL

References

[1]	"Sequence and transcriptional analysis of a DNA region involved in the production of capsular polysaccharide in Streptococcus pneumoniae type 3." Arrecubieta C., Garcia E., Lopez R. Gene 167:1-7(1995) [PubMed: 8566758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 406 / Type 3.
[2]	"Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniae." Dillard J.P., Vandersea M.W., Yother J. J. Exp. Med. 181:973-983(1995) [PubMed: 7869055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WU2 / Serotype 3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z47210 Genomic DNA. Translation: CAA87405.1. U15171 Genomic DNA. Translation: AAC43313.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.9. 600.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAP3C_STRPN

Accession

Primary (citable) accession number: Q54800
Secondary accession number(s): Q54612

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	September 22, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)