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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

cap3C

Organism
Streptococcus pneumoniae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Enzyme and pathway databases

UniPathwayiUPA00215.
UPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:cap3C
Synonyms:cps3U
OrganismiStreptococcus pneumoniae
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306UTP--glucose-1-phosphate uridylyltransferasePRO_0000201365Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVKKAVIP AAGLGTRFLP ATKALAKEML PIVDRPTIHF VIEEALRSGI
60 70 80 90 100
EDILVVTGKS KRSIEDYFDS TFELEYSLRK QGKMELLKSV NESTDIKVHF
110 120 130 140 150
VRQSSPRGLG DAVLQAKSFV GDDPFVVMLG DDLMDITDST AVPLTRQLMD
160 170 180 190 200
DYNATQASTI AVMPVRYEDV SSYGVISPRL ESSNGLYSVD AFVEKPKPEE
210 220 230 240 250
APSNLAIIGR YLLTPEIFSI LETQKPGAGN EIQLTDAIDT LNKTQSVFAR
260 270 280 290 300
EFVGKRYDVG DKFNFMKTSI DYALQHPQIK ESLKNYVIAL GKQLEKLDDC

SSSGHL
Length:306
Mass (Da):33,919
Last modified:October 31, 1996 - v1
Checksum:iF8E243D00F47EEA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041N → H in AAC43313 (PubMed:7869055).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47210 Genomic DNA. Translation: CAA87405.1.
U15171 Genomic DNA. Translation: AAC43313.1.
RefSeqiWP_000756065.1. NZ_JFJH01000024.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47210 Genomic DNA. Translation: CAA87405.1.
U15171 Genomic DNA. Translation: AAC43313.1.
RefSeqiWP_000756065.1. NZ_JFJH01000024.1.

3D structure databases

ProteinModelPortaliQ54800.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00215.
UPA00934.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence and transcriptional analysis of a DNA region involved in the production of capsular polysaccharide in Streptococcus pneumoniae type 3."
    Arrecubieta C., Garcia E., Lopez R.
    Gene 167:1-7(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 406 / Type 3.
  2. "Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in Streptococcus pneumoniae."
    Dillard J.P., Vandersea M.W., Yother J.
    J. Exp. Med. 181:973-983(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WU2 / Serotype 3.

Entry informationi

Entry nameiCAP3C_STREE
AccessioniPrimary (citable) accession number: Q54800
Secondary accession number(s): Q54612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1996
Last modified: January 6, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.