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Q547J2

- Q547J2_HPV16

UniProt

Q547J2 - Q547J2_HPV16

Protein
Submitted name:

E6

Gene

E6

Organism
Human papillomavirus type 16
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    E6Imported
    Submitted name:
    E6 proteinImported
    Submitted name:
    Early protein E6Imported
    Submitted name:
    Transforming protein E6Imported
    Gene namesi
    Name:E6Imported
    OrganismiHuman papillomavirus type 16Imported
    Taxonomic identifieri333760 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Host nucleus matrix SAAS annotation

    GO - Cellular componenti

    1. host cell nuclear matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleusSAAS annotation

    Structurei

    3D structure databases

    SMRiQ547J2. Positions 88-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR001334. E6.
    [Graphical view]
    PfamiPF00518. E6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q547J2-1 [UniParc]FASTAAdd to Basket

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    MHQKRTAMFQ DPQERPRKLP QLCTELQTTI HDIILECVYC KQQLLRREVY    50
    DFAFRDLCIV YRDGNPYAVC DKCLKFYSKI SEYRHYCYSL YGTTLEQQYN 100
    KPLCDLLIRC INCQKPLCPE EKQRHLDKKQ RFHNIRGRWT GRCMSCCRSS 150
    RTRRETQL 158
    Length:158
    Mass (Da):19,187
    Last modified:May 24, 2005 - v1
    Checksum:i01FEF5ADCFDB37EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF486310 Genomic DNA. Translation: AAL96615.1.
    AF486311 Genomic DNA. Translation: AAL96616.1.
    AF486312 Genomic DNA. Translation: AAL96617.1.
    AF486313 Genomic DNA. Translation: AAL96618.1.
    AF486317 Genomic DNA. Translation: AAL96622.1.
    AF486320 Genomic DNA. Translation: AAL96625.1.
    AF486321 Genomic DNA. Translation: AAL96626.1.
    AY098919 Genomic DNA. Translation: AAM29167.1.
    AY686581 Genomic DNA. Translation: AAV91660.1.
    AY686584 Genomic DNA. Translation: AAV91684.1.
    EF422095 Genomic DNA. Translation: ABR08416.1.
    EF422096 Genomic DNA. Translation: ABR08417.1.
    EF422097 Genomic DNA. Translation: ABR08418.1.
    EF422098 Genomic DNA. Translation: ABR08419.1.
    EF422104 Genomic DNA. Translation: ABR08425.1.
    EF422106 Genomic DNA. Translation: ABR08427.1.
    EF422107 Genomic DNA. Translation: ABR08428.1.
    EF422108 Genomic DNA. Translation: ABR08429.1.
    EU880247 Genomic DNA. Translation: ACK57856.1.
    EU880248 Genomic DNA. Translation: ACK57857.1.
    EU880249 Genomic DNA. Translation: ACK57858.1.
    EU880250 Genomic DNA. Translation: ACK57859.1.
    EU880251 Genomic DNA. Translation: ACK57860.1.
    EU880252 Genomic DNA. Translation: ACK57861.1.
    EU880254 Genomic DNA. Translation: ACK57862.1.
    EU880257 Genomic DNA. Translation: ACK57864.1.
    EU880258 Genomic DNA. Translation: ACK57865.1.
    EU880259 Genomic DNA. Translation: ACK57866.1.
    EU880260 Genomic DNA. Translation: ACK57867.1.
    EU880262 Genomic DNA. Translation: ACK57868.1.
    EU880263 Genomic DNA. Translation: ACK57869.1.
    EU880265 Genomic DNA. Translation: ACK57871.1.
    EU880266 Genomic DNA. Translation: ACK57872.1.
    EU880267 Genomic DNA. Translation: ACK57873.1.
    EU880268 Genomic DNA. Translation: ACK57874.1.
    EU880269 Genomic DNA. Translation: ACK57875.1.
    EU880270 Genomic DNA. Translation: ACK57876.1.
    EU880271 Genomic DNA. Translation: ACK57877.1.
    EU880272 Genomic DNA. Translation: ACK57878.1.
    FJ610146 Genomic DNA. Translation: ACS92644.1.
    FJ610149 Genomic DNA. Translation: ACS92668.1.
    FJ610150 Genomic DNA. Translation: ACS92676.1.
    HM211089 Genomic DNA. Translation: ADY75575.1.
    JN381047 Genomic DNA. Translation: AEV66127.1.
    JN381057 Genomic DNA. Translation: AEV66137.1.
    JN381061 Genomic DNA. Translation: AEV66141.1.
    JX412120 Genomic DNA. Translation: AFS64234.1.
    KC736930 Genomic DNA. Translation: AGK72246.1.
    KC904798 Genomic DNA. Translation: AGS42242.1.
    KC904799 Genomic DNA. Translation: AGS42243.1.
    KC904800 Genomic DNA. Translation: AGS42244.1.
    KC904801 Genomic DNA. Translation: AGS42245.1.
    KC904802 Genomic DNA. Translation: AGS42246.1.
    KC904824 Genomic DNA. Translation: AGS42268.1.
    KC904911 Genomic DNA. Translation: AGS42355.1.
    AB663688 Genomic DNA. Translation: BAN15903.1.
    AB663690 Genomic DNA. Translation: BAN15905.1.
    AB663691 Genomic DNA. Translation: BAN15906.1.
    AB663692 Genomic DNA. Translation: BAN15907.1.
    AB663695 Genomic DNA. Translation: BAN15910.1.
    AB663696 Genomic DNA. Translation: BAN15911.1.
    AB663700 Genomic DNA. Translation: BAN15915.1.
    AB663706 Genomic DNA. Translation: BAN15921.1.
    AB663718 Genomic DNA. Translation: BAN15933.1.
    AB663724 Genomic DNA. Translation: BAN15939.1.
    AB663727 Genomic DNA. Translation: BAN15942.1.
    AB663730 Genomic DNA. Translation: BAN15945.1.
    AB663734 Genomic DNA. Translation: BAN15949.1.
    AB663735 Genomic DNA. Translation: BAN15950.1.
    AB663737 Genomic DNA. Translation: BAN15952.1.
    AB663739 Genomic DNA. Translation: BAN15954.1.
    AB663741 Genomic DNA. Translation: BAN15956.1.
    RefSeqiNP_041325.1. NC_001526.2.

    Genome annotation databases

    GeneIDi1489078.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF486310 Genomic DNA. Translation: AAL96615.1 .
    AF486311 Genomic DNA. Translation: AAL96616.1 .
    AF486312 Genomic DNA. Translation: AAL96617.1 .
    AF486313 Genomic DNA. Translation: AAL96618.1 .
    AF486317 Genomic DNA. Translation: AAL96622.1 .
    AF486320 Genomic DNA. Translation: AAL96625.1 .
    AF486321 Genomic DNA. Translation: AAL96626.1 .
    AY098919 Genomic DNA. Translation: AAM29167.1 .
    AY686581 Genomic DNA. Translation: AAV91660.1 .
    AY686584 Genomic DNA. Translation: AAV91684.1 .
    EF422095 Genomic DNA. Translation: ABR08416.1 .
    EF422096 Genomic DNA. Translation: ABR08417.1 .
    EF422097 Genomic DNA. Translation: ABR08418.1 .
    EF422098 Genomic DNA. Translation: ABR08419.1 .
    EF422104 Genomic DNA. Translation: ABR08425.1 .
    EF422106 Genomic DNA. Translation: ABR08427.1 .
    EF422107 Genomic DNA. Translation: ABR08428.1 .
    EF422108 Genomic DNA. Translation: ABR08429.1 .
    EU880247 Genomic DNA. Translation: ACK57856.1 .
    EU880248 Genomic DNA. Translation: ACK57857.1 .
    EU880249 Genomic DNA. Translation: ACK57858.1 .
    EU880250 Genomic DNA. Translation: ACK57859.1 .
    EU880251 Genomic DNA. Translation: ACK57860.1 .
    EU880252 Genomic DNA. Translation: ACK57861.1 .
    EU880254 Genomic DNA. Translation: ACK57862.1 .
    EU880257 Genomic DNA. Translation: ACK57864.1 .
    EU880258 Genomic DNA. Translation: ACK57865.1 .
    EU880259 Genomic DNA. Translation: ACK57866.1 .
    EU880260 Genomic DNA. Translation: ACK57867.1 .
    EU880262 Genomic DNA. Translation: ACK57868.1 .
    EU880263 Genomic DNA. Translation: ACK57869.1 .
    EU880265 Genomic DNA. Translation: ACK57871.1 .
    EU880266 Genomic DNA. Translation: ACK57872.1 .
    EU880267 Genomic DNA. Translation: ACK57873.1 .
    EU880268 Genomic DNA. Translation: ACK57874.1 .
    EU880269 Genomic DNA. Translation: ACK57875.1 .
    EU880270 Genomic DNA. Translation: ACK57876.1 .
    EU880271 Genomic DNA. Translation: ACK57877.1 .
    EU880272 Genomic DNA. Translation: ACK57878.1 .
    FJ610146 Genomic DNA. Translation: ACS92644.1 .
    FJ610149 Genomic DNA. Translation: ACS92668.1 .
    FJ610150 Genomic DNA. Translation: ACS92676.1 .
    HM211089 Genomic DNA. Translation: ADY75575.1 .
    JN381047 Genomic DNA. Translation: AEV66127.1 .
    JN381057 Genomic DNA. Translation: AEV66137.1 .
    JN381061 Genomic DNA. Translation: AEV66141.1 .
    JX412120 Genomic DNA. Translation: AFS64234.1 .
    KC736930 Genomic DNA. Translation: AGK72246.1 .
    KC904798 Genomic DNA. Translation: AGS42242.1 .
    KC904799 Genomic DNA. Translation: AGS42243.1 .
    KC904800 Genomic DNA. Translation: AGS42244.1 .
    KC904801 Genomic DNA. Translation: AGS42245.1 .
    KC904802 Genomic DNA. Translation: AGS42246.1 .
    KC904824 Genomic DNA. Translation: AGS42268.1 .
    KC904911 Genomic DNA. Translation: AGS42355.1 .
    AB663688 Genomic DNA. Translation: BAN15903.1 .
    AB663690 Genomic DNA. Translation: BAN15905.1 .
    AB663691 Genomic DNA. Translation: BAN15906.1 .
    AB663692 Genomic DNA. Translation: BAN15907.1 .
    AB663695 Genomic DNA. Translation: BAN15910.1 .
    AB663696 Genomic DNA. Translation: BAN15911.1 .
    AB663700 Genomic DNA. Translation: BAN15915.1 .
    AB663706 Genomic DNA. Translation: BAN15921.1 .
    AB663718 Genomic DNA. Translation: BAN15933.1 .
    AB663724 Genomic DNA. Translation: BAN15939.1 .
    AB663727 Genomic DNA. Translation: BAN15942.1 .
    AB663730 Genomic DNA. Translation: BAN15945.1 .
    AB663734 Genomic DNA. Translation: BAN15949.1 .
    AB663735 Genomic DNA. Translation: BAN15950.1 .
    AB663737 Genomic DNA. Translation: BAN15952.1 .
    AB663739 Genomic DNA. Translation: BAN15954.1 .
    AB663741 Genomic DNA. Translation: BAN15956.1 .
    RefSeqi NP_041325.1. NC_001526.2.

    3D structure databases

    SMRi Q547J2. Positions 88-151.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1489078.

    Family and domain databases

    InterProi IPR001334. E6.
    [Graphical view ]
    Pfami PF00518. E6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern China."
      Chan P.K.S., Lam C.W., Cheung T.H., Li W.W.H., Lo K.W.K., Chan M.Y.M., Cheung J.L.K., Xu L.Y., Cheng A.F.
      J. Infect. Dis. 186:696-700(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: E-G187TImported, E-G241TImported, E-G538TImported and E-PImported.
    2. "Human papillomavirus type 16 variants in Central Brazil."
      Cruz M.R., Cerqueira D.M., Camara G.N.L., Silva E.O., Carvalho L.G.S., Martins C.R.F.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Bsb-102Imported.
    3. "Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses."
      Chen Z., Terai M., Fu L., Herrero R., DeSalle R., Burk R.D.
      J. Virol. 79:7014-7023(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Qv15521EImported and Qv17722EImported.
    4. "Genetic variability in E6 and E7 genes of human papillomavirus -16, - 18, -31 and -33 from HIV-1-positive women in Italy."
      Garbuglia A.R., Carletti F., Minosse C., Piselli P., Zaniratti M.S., Serraino D., Capobianchi M.R.
      New Microbiol. 30:377-382(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: P170Imported, P209Imported, P318Imported, P343Imported, P385Imported, P403Imported, P42Imported and P799Imported.
    5. "Human papillomavirus type 16 variants in San Luis Potosi City, Mexico."
      Lopez-Revilla R., Pineda M.A., Ortiz-Valdez J., Sanchez-Garza M., Riego L.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HPV16-13Imported, HPV16-14Imported, HPV16-15Imported, HPV16-16Imported, HPV16-17Imported, HPV16-18Imported, HPV16-20Imported, HPV16-23Imported, HPV16-24Imported, HPV16-25Imported, HPV16-26Imported, HPV16-28Imported, HPV16-29Imported, HPV16-31Imported, HPV16-32Imported, HPV16-33Imported, HPV16-34Imported, HPV16-35Imported, HPV16-36Imported, HPV16-37Imported and HPV16-38Imported.
    6. "Entire genome characterization of human papillomavirus type 16 from infected Thai women with different cytological findings."
      Lurchachaiwong W., Junyangdikul P., Payungporn S., Chansaenroj J., Sampathanukul P., Tresukosol D., Termrungruanglert W., Theamboonlers A., Poovorawan Y.
      Virus Genes 39:30-38(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CU1Imported, CU4Imported and CU5Imported.
    7. "Phylogenetic analysis of E6 gene in Human papillomavirus type 16."
      Tsakogiannis D., Rouether I.G.A., Markoulatos P.
      Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 796Imported.
    8. "Human papillomavirus type 16 variants and their oncogenicity."
      Sasaki T., Fujita H., Kikuchi K.
      Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 05-440Imported, 08-219Imported and 08-257Imported.
    9. "Distribution of Human Papillomavirus and E6/E7 Variation."
      Lijuan Y.
      Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PE19Imported.
    10. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: J06-008Imported, J06-029Imported, J06-030Imported, J06-046Imported, J06-088Imported, J07-004Imported, J07-092Imported, J07-129Imported, J07-199Imported, P1-145Imported, P1-191Imported, P1-98Imported, P7-108Imported, P7-12Imported, P7-5Imported, P7-69Imported and P7-84Imported.
    11. "Characterisation of HPV16 Genome."
      Siddiqa A., Bhatti M.F., Parish J.L.
      Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: AS-001Imported.
    12. "Analysis of mutations in the E6 oncogene of Human Papillomavirus 16 in cervical cancer isolates from Moroccan women."
      Qmichou Z., El Mzibri M., Ennaji M.M., Khyatti M., Attaleb M.
      Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: E-G289Imported, E-T350/rImported and NA1Imported.

    Entry informationi

    Entry nameiQ547J2_HPV16
    AccessioniPrimary (citable) accession number: Q547J2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)