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Protein

Receptor-interacting serine/threonine-protein kinase 2

Gene

Ripk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei47ATPUniRule annotation1
Active sitei146Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 32ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotation, Transferase
Biological processAdaptive immunityUniRule annotation, Immunity, Innate immunityUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-interacting serine/threonine-protein kinase 2UniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Tyrosine-protein kinase RIPK2UniRule annotation
Gene namesi
Name:Ripk2Imported
ORF Names:mCG_19039Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1891456 Ripk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ547H1

Expressioni

Gene expression databases

BgeeiENSMUSG00000041135
ExpressionAtlasiQ547H1 baseline and differential

Interactioni

Subunit structurei

Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
UbcP629914EBI-7733331,EBI-413074

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-44657N
IntActiQ547H1, 1 interactor

Structurei

3D structure databases

SMRiQ547H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 294Protein kinaseInterPro annotationAdd BLAST277
Domaini435 – 513CARDInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOVERGENiHBG054242
KOiK08846
OMAiQWIQSKR
OrthoDBiEOG091G0505

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017322 Rcpt-int_Ser/Thr_kinase-2
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF037921 STPK_RIP2, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q547H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGDAICSAL PPIPYHKLAD LHYLSRGASG TVSSARHADW RVRVAVKHLH
60 70 80 90 100
IHTPLLDSER NDILREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN
110 120 130 140 150
GSLNELLHRK TEYPDIAWPL RFRILHEIAL GVNYLHNMNP PLLHHDLKTQ
160 170 180 190 200
NILLDNEFHV KIADFGLSKW RMMSLSQSRS YKSAPEGGTI IYMPPENYEP
210 220 230 240 250
GQKSRASVKH DIYSYAVIMW EVLSRKQPFE EVTNPLQIMY SVSQGHRPDT
260 270 280 290 300
SEENLPFDIP HRGLMISLIQ SGWAQNPDER PSFLKCLIEL EPVLRTFEDI
310 320 330 340 350
TFLEAVIQLK KAKIQSSSST IHLCDKKMDL SLNIPANHPP QEESCGSSLL
360 370 380 390 400
SRNTGSPGPS RSLSAPQDKG FLSGAPQDCS SLKAHHCPGN HSWDGIVSVP
410 420 430 440 450
PGAAFCDRRA SSCSLAVISP FLVEKGSERP PIGIAQQWIQ SKREAIVSQM
460 470 480 490 500
TEACLNQSLD ALLSRDLIMK EDYELISTKP TRTSKVRQLL DTSDIQGEEF
510 520 530
AKVVVQKLKD NKQLGLQPYP EVPVLSKAPP SNFPQNKSL
Length:539
Mass (Da):60,400
Last modified:May 24, 2005 - v1
Checksum:i42951BF97CA15DFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487539 mRNA Translation: AAM76919.1
AK159593 mRNA Translation: BAE35213.1
AK172319 mRNA Translation: BAE42942.1
AK172417 mRNA Translation: BAE42997.1
CH466538 Genomic DNA Translation: EDL05589.1
RefSeqiNP_620402.1, NM_138952.4
UniGeneiMm.112765

Genome annotation databases

GeneIDi192656
KEGGimmu:192656

Similar proteinsi

Entry informationi

Entry nameiQ547H1_MOUSE
AccessioniPrimary (citable) accession number: Q547H1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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