E7 - Protein E7 - Human papillomavirus type 16

Functionⁱ

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.SAAS annotation

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processⁱ

modulation by virus of host G1/S transition checkpoint Source: UniProtKB-KW
suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywords - Molecular functionⁱ

ActivatorSAAS annotation

Keywords - Biological processⁱ

G1/S host cell cycle checkpoint dysregulation by virusSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virusSAAS annotation, Modulation of host cell cycle by virus, Transcription, Transcription regulationSAAS annotation, Viral immunoevasion

Keywords - Ligandⁱ

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein E7SAAS annotation Automatic assertion according to rulesⁱ SAAS:SAAS00614352
Gene namesⁱ	Name:E7Imported Automatic assertion inferred from database entriesⁱ EMBL:AAM74160.1
Organismⁱ	Human papillomavirus type 16Imported Automatic assertion inferred from database entriesⁱ EMBL:AAM74160.1
Taxonomic identifierⁱ	333760 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Alphapapillomavirus › Alphapapillomavirus 9
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]

Subcellular locationⁱ

Host cytoplasm
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00614355

Host nucleus
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00614351

GO - Cellular componentⁱ

host cell cytoplasm Source: UniProtKB-SubCell
host cell nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Host cytoplasmSAAS annotation, Host nucleusSAAS annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q547B8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the papillomaviridae E7 protein family.SAAS annotation

Keywords - Domainⁱ

Zinc-fingerSAAS annotation

Family and domain databases

HAMAPⁱ	MF_04004. PPV_E7. 1 hit.
InterProⁱ	IPR000148. Papilloma_E7. [Graphical view]
Pfamⁱ	PF00527. E7. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF003407. Papvi_E7. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q547B8-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MHGDTPTLHE YMLDLQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA 
        60         70         80         90 
HYNIVTFCCK CDSTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP

Length:98

Mass (Da):11,022

Last modified:May 24, 2005 - v1

Checksum:ⁱ9BD612534CD2C9EB

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Non-terminal residueⁱ	98 – 98	1	Imported Automatic assertion inferred from database entriesⁱ EMBL:AAM74160.1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF512012 Genomic DNA. Translation: AAM74160.1.
RefSeqⁱ	NP_041326.1. NC_001526.2.

Genome annotation databases

GeneIDⁱ	1489079.
KEGGⁱ	vg:1489079.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF512012 Genomic DNA. Translation: AAM74160.1.
RefSeqⁱ	NP_041326.1. NC_001526.2.

3D structure databases

ProteinModelPortalⁱ	Q547B8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	1489079.
KEGGⁱ	vg:1489079.

Family and domain databases

HAMAPⁱ	MF_04004. PPV_E7. 1 hit.
InterProⁱ	IPR000148. Papilloma_E7. [Graphical view]
Pfamⁱ	PF00527. E7. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF003407. Papvi_E7. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

Q547B8_HPV16

Accessionⁱ

Primary (citable) accession number: Q547B8

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	July 6, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB - Q547B8 (Q547B8_HPV16)

UniProt

Q547B8 - Q547B8_HPV16

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Protein E7

E7

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywords - Molecular functionⁱ

Keywords - Biological processⁱ

Keywords - Ligandⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

Entry informationⁱ

Similar proteinsⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q547B8 (Q547B8_HPV16)

UniProt

Q547B8 - Q547B8_HPV16

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Protein E7

E7

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ