UniProtKB - Q547B8 (Q547B8_HPV16)
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Protein
Protein E7
Gene
E7
Organism
Human papillomavirus type 16
Status
Functioni
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.SAAS annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- transcription factor activity, sequence-specific DNA binding Source: InterPro
GO - Biological processi
- modulation by virus of host G1/S transition checkpoint Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
| Molecular function | ActivatorSAAS annotation, DNA-bindingSAAS annotation |
| Biological process | G1/S host cell cycle checkpoint dysregulation by virusSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virusSAAS annotation, Modulation of host cell cycle by virus, Transcription, Transcription regulationSAAS annotation, Viral immunoevasion |
| Ligand | Metal-binding, Zinc |
Names & Taxonomyi
| Protein namesi | Recommended name: Protein E7SAAS annotation |
| Gene namesi | Name:E7Imported |
| Organismi | Human papillomavirus type 16Imported |
| Taxonomic identifieri | 333760 [NCBI] |
| Taxonomic lineagei | Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Alphapapillomavirus › |
| Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Subcellular locationi
- Host cytoplasm SAAS annotation
- Host nucleus SAAS annotation
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cytoplasmSAAS annotation, Host nucleusSAAS annotationStructurei
3D structure databases
| ProteinModelPortali | Q547B8. |
| SMRi | Q547B8. |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the papillomaviridae E7 protein family.SAAS annotation
Keywords - Domaini
Zinc-fingerSAAS annotationFamily and domain databases
| HAMAPi | MF_04004. PPV_E7. 1 hit. |
| InterProi | View protein in InterPro IPR000148. Papilloma_E7. |
| Pfami | View protein in Pfam PF00527. E7. 1 hit. |
| PIRSFi | PIRSF003407. Papvi_E7. 1 hit. |
Sequencei
Sequence statusi: Fragment.
Q547B8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHGDTPTLHE YMLDLQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA
60 70 80 90
HYNIVTFCCK CDSTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Non-terminal residuei | 98 | Imported | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF512012 Genomic DNA. Translation: AAM74160.1. |
| RefSeqi | NP_041326.1. NC_001526.4. |
Genome annotation databases
| GeneIDi | 1489079. |
| KEGGi | vg:1489079. |
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF512012 Genomic DNA. Translation: AAM74160.1. |
| RefSeqi | NP_041326.1. NC_001526.4. |
3D structure databases
| ProteinModelPortali | Q547B8. |
| SMRi | Q547B8. |
| ModBasei | Search... |
| MobiDBi | Search... |
Protocols and materials databases
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| GeneIDi | 1489079. |
| KEGGi | vg:1489079. |
Family and domain databases
| HAMAPi | MF_04004. PPV_E7. 1 hit. |
| InterProi | View protein in InterPro IPR000148. Papilloma_E7. |
| Pfami | View protein in Pfam PF00527. E7. 1 hit. |
| PIRSFi | PIRSF003407. Papvi_E7. 1 hit. |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | Q547B8_HPV16 | |
| Accessioni | Q547B8Primary (citable) accession number: Q547B8 | |
| Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
| Last sequence update: | May 24, 2005 | |
| Last modified: | June 7, 2017 | |
| This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |