UniProtKB - Q547B8 (Q547B8_HPV16)
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Protein
Protein E7
Gene
E7
Organism
Human papillomavirus type 16
Status
Functioni
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).SAAS annotation
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- modulation by virus of host G1/S transition checkpoint Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | ActivatorSAAS annotation, DNA-bindingSAAS annotation |
Biological process | G1/S host cell cycle checkpoint dysregulation by virusSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virusSAAS annotation, Modulation of host cell cycle by virus, Transcription, Transcription regulationSAAS annotation, Viral immunoevasion |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein E7SAAS annotation |
Gene namesi | Name:E7Imported |
Organismi | Human papillomavirus type 16Imported |
Taxonomic identifieri | 333760 [NCBI] |
Taxonomic lineagei | Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Alphapapillomavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Subcellular locationi
- Host cytoplasm SAAS annotation
- Host nucleus SAAS annotation
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cytoplasmSAAS annotation, Host nucleusSAAS annotationStructurei
3D structure databases
ProteinModelPortali | Q547B8 |
SMRi | Q547B8 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the papillomaviridae E7 protein family.SAAS annotation
Keywords - Domaini
Zinc-fingerSAAS annotationPhylogenomic databases
KOi | K21809 |
Family and domain databases
HAMAPi | MF_04004 PPV_E7, 1 hit |
InterProi | View protein in InterPro IPR000148 Papilloma_E7 |
Pfami | View protein in Pfam PF00527 E7, 1 hit |
PIRSFi | PIRSF003407 Papvi_E7, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q547B8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHGDTPTLHE YMLDLQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA
60 70 80 90
HYNIVTFCCK CDSTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 98 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF512012 Genomic DNA Translation: AAM74160.1 |
RefSeqi | NP_041326.1, NC_001526.4 |
Genome annotation databases
GeneIDi | 1489079 |
KEGGi | vg:1489079 |
Similar proteinsi
Entry informationi
Entry namei | Q547B8_HPV16 | |
Accessioni | Q547B8Primary (citable) accession number: Q547B8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 24, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 28, 2018 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |