Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q54769 (GCH1_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:Synpcc7942_1597
ORF Names:sec0031
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence caution

The sequence AAB82043.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAM82644.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119457

Sites

Metal binding981Zinc By similarity
Metal binding1011Zinc By similarity
Metal binding1691Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54769 [UniParc].

Last modified October 10, 2002. Version 2.
Checksum: 4DA8E3F94B84BE45

FASTA21323,715
        10         20         30         40         50         60 
MTSPSLNGSN SLVDAIRPET EAVSQAEMEA AVRTLLLGVG EDPEREGLLK TPKRVAEAYR 

        70         80         90        100        110        120 
FLTSGYSQSL DDLVNGAIFD EGHNEMVLVR DITAFSLCEH HMLPFMGKVH VAYIPNQKVV 

       130        140        150        160        170        180 
GLSKLARIVE MYSRRLQVQE RLTRQIAESV QEILDPQGVA VVMEATHMCM VMRGVQKPGS 

       190        200        210 
WTVTSAMVGV FQEDQRTREE FLSLIRHQPA AFA 

« Hide

References

« Hide 'large scale' references
[1]"Genes encoding the alpha subunit of carboxyltransferase of the acetyl-CoA carboxylase complex and GTP cyclohydrolase I from cyanobacterium Synechococcus sp. PCC 7942."
Phung L.T., Haselkorn R.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Synechococcus elongatus PCC7942 cosmid 6C3."
Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59236 Genomic DNA. Translation: AAB82043.1. Different initiation.
AY120852 Genomic DNA. Translation: AAM82644.1. Different initiation.
CP000100 Genomic DNA. Translation: ABB57627.1.
RefSeqYP_400614.1. NC_007604.1.

3D structure databases

ProteinModelPortalQ54769.
SMRQ54769. Positions 17-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_1597.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB57627; ABB57627; Synpcc7942_1597.
GeneID3775021.
KEGGsyf:Synpcc7942_1597.
PATRIC23788589. VBISynElo51371_1818.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_1597-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_SYNE7
AccessionPrimary (citable) accession number: Q54769
Secondary accession number(s): Q31MU2, Q8KPT2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways