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Q54769

- GCH1_SYNE7

UniProt

Q54769 - GCH1_SYNE7

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981ZincBy similarity
    Metal bindingi101 – 1011ZincBy similarity
    Metal bindingi169 – 1691ZincBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_1597-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1 (EC:3.5.4.16)
    Alternative name(s):
    GTP cyclohydrolase I
    Short name:
    GTP-CH-I
    Gene namesi
    Name:folE
    Ordered Locus Names:Synpcc7942_1597
    ORF Names:sec0031
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213GTP cyclohydrolase 1PRO_0000119457Add
    BLAST

    Interactioni

    Subunit structurei

    Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_1597.

    Structurei

    3D structure databases

    ProteinModelPortaliQ54769.
    SMRiQ54769. Positions 17-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54769-1 [UniParc]FASTAAdd to Basket

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    MTSPSLNGSN SLVDAIRPET EAVSQAEMEA AVRTLLLGVG EDPEREGLLK    50
    TPKRVAEAYR FLTSGYSQSL DDLVNGAIFD EGHNEMVLVR DITAFSLCEH 100
    HMLPFMGKVH VAYIPNQKVV GLSKLARIVE MYSRRLQVQE RLTRQIAESV 150
    QEILDPQGVA VVMEATHMCM VMRGVQKPGS WTVTSAMVGV FQEDQRTREE 200
    FLSLIRHQPA AFA 213
    Length:213
    Mass (Da):23,715
    Last modified:October 10, 2002 - v2
    Checksum:i4DA8E3F94B84BE45
    GO

    Sequence cautioni

    The sequence AAB82043.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAM82644.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59236 Genomic DNA. Translation: AAB82043.1. Different initiation.
    AY120852 Genomic DNA. Translation: AAM82644.1. Different initiation.
    CP000100 Genomic DNA. Translation: ABB57627.1.
    RefSeqiYP_400614.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB57627; ABB57627; Synpcc7942_1597.
    GeneIDi3775021.
    KEGGisyf:Synpcc7942_1597.
    PATRICi23788589. VBISynElo51371_1818.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59236 Genomic DNA. Translation: AAB82043.1 . Different initiation.
    AY120852 Genomic DNA. Translation: AAM82644.1 . Different initiation.
    CP000100 Genomic DNA. Translation: ABB57627.1 .
    RefSeqi YP_400614.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali Q54769.
    SMRi Q54769. Positions 17-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_1597.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB57627 ; ABB57627 ; Synpcc7942_1597 .
    GeneIDi 3775021.
    KEGGi syf:Synpcc7942_1597.
    PATRICi 23788589. VBISynElo51371_1818.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci SYNEL:SYNPCC7942_1597-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes encoding the alpha subunit of carboxyltransferase of the acetyl-CoA carboxylase complex and GTP cyclohydrolase I from cyanobacterium Synechococcus sp. PCC 7942."
      Phung L.T., Haselkorn R.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Synechococcus elongatus PCC7942 cosmid 6C3."
      Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiGCH1_SYNE7
    AccessioniPrimary (citable) accession number: Q54769
    Secondary accession number(s): Q31MU2, Q8KPT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3