Q54769 (GCH1_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	Synpcc7942_1597
ORF Names:	sec0031

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.
Sequence caution	The sequence AAB82043.1 differs from that shown. Reason: Erroneous initiation. The sequence AAM82644.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_0000119457
Sites
	Metal binding	98	1	Zinc By similarity
	Metal binding	101	1	Zinc By similarity
	Metal binding	169	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q54769 [UniParc]. Last modified October 10, 2002. Version 2. Checksum: 4DA8E3F94B84BE45	FASTA	213	23,715
	10 20 30 40 50 60 MTSPSLNGSN SLVDAIRPET EAVSQAEMEA AVRTLLLGVG EDPEREGLLK TPKRVAEAYR 70 80 90 100 110 120 FLTSGYSQSL DDLVNGAIFD EGHNEMVLVR DITAFSLCEH HMLPFMGKVH VAYIPNQKVV 130 140 150 160 170 180 GLSKLARIVE MYSRRLQVQE RLTRQIAESV QEILDPQGVA VVMEATHMCM VMRGVQKPGS 190 200 210 WTVTSAMVGV FQEDQRTREE FLSLIRHQPA AFA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genes encoding the alpha subunit of carboxyltransferase of the acetyl-CoA carboxylase complex and GTP cyclohydrolase I from cyanobacterium Synechococcus sp. PCC 7942." Phung L.T., Haselkorn R. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Synechococcus elongatus PCC7942 cosmid 6C3." Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59236 Genomic DNA. Translation: AAB82043.1. Different initiation. AY120852 Genomic DNA. Translation: AAM82644.1. Different initiation. CP000100 Genomic DNA. Translation: ABB57627.1.
RefSeq	YP_400614.1. NC_007604.1.
3D structure databases
ProteinModelPortal	Q54769.
SMR	Q54769. Positions 17-206.
ModBase	Search...
Protein-protein interaction databases
STRING	1140.Synpcc7942_1597.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB57627; ABB57627; Synpcc7942_1597.
GeneID	3775021.
KEGG	syf:Synpcc7942_1597.
PATRIC	23788589. VBISynElo51371_1818.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	SELO1140:GJWQ-1624-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_SYNE7

Accession

Primary (citable) accession number: Q54769
Secondary accession number(s): Q31MU2, Q8KPT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 10, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program