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Q54769

- GCH1_SYNE7

UniProt

Q54769 - GCH1_SYNE7

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Protein
GTP cyclohydrolase 1
Gene
folE, Synpcc7942_1597, sec0031
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Zinc By similarity
Metal bindingi101 – 1011Zinc By similarity
Metal bindingi169 – 1691Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1597-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:Synpcc7942_1597
ORF Names:sec0031
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213GTP cyclohydrolase 1UniRule annotation
PRO_0000119457Add
BLAST

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1597.

Structurei

3D structure databases

ProteinModelPortaliQ54769.
SMRiQ54769. Positions 17-206.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54769-1 [UniParc]FASTAAdd to Basket

« Hide

MTSPSLNGSN SLVDAIRPET EAVSQAEMEA AVRTLLLGVG EDPEREGLLK    50
TPKRVAEAYR FLTSGYSQSL DDLVNGAIFD EGHNEMVLVR DITAFSLCEH 100
HMLPFMGKVH VAYIPNQKVV GLSKLARIVE MYSRRLQVQE RLTRQIAESV 150
QEILDPQGVA VVMEATHMCM VMRGVQKPGS WTVTSAMVGV FQEDQRTREE 200
FLSLIRHQPA AFA 213
Length:213
Mass (Da):23,715
Last modified:October 10, 2002 - v2
Checksum:i4DA8E3F94B84BE45
GO

Sequence cautioni

The sequence AAB82043.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAM82644.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59236 Genomic DNA. Translation: AAB82043.1. Different initiation.
AY120852 Genomic DNA. Translation: AAM82644.1. Different initiation.
CP000100 Genomic DNA. Translation: ABB57627.1.
RefSeqiYP_400614.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB57627; ABB57627; Synpcc7942_1597.
GeneIDi3775021.
KEGGisyf:Synpcc7942_1597.
PATRICi23788589. VBISynElo51371_1818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59236 Genomic DNA. Translation: AAB82043.1 . Different initiation.
AY120852 Genomic DNA. Translation: AAM82644.1 . Different initiation.
CP000100 Genomic DNA. Translation: ABB57627.1 .
RefSeqi YP_400614.1. NC_007604.1.

3D structure databases

ProteinModelPortali Q54769.
SMRi Q54769. Positions 17-206.
ModBasei Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_1597.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB57627 ; ABB57627 ; Synpcc7942_1597 .
GeneIDi 3775021.
KEGGi syf:Synpcc7942_1597.
PATRICi 23788589. VBISynElo51371_1818.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SYNEL:SYNPCC7942_1597-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes encoding the alpha subunit of carboxyltransferase of the acetyl-CoA carboxylase complex and GTP cyclohydrolase I from cyanobacterium Synechococcus sp. PCC 7942."
    Phung L.T., Haselkorn R.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Synechococcus elongatus PCC7942 cosmid 6C3."
    Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiGCH1_SYNE7
AccessioniPrimary (citable) accession number: Q54769
Secondary accession number(s): Q31MU2, Q8KPT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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