Reviewed, UniProtKB/Swiss-Prot Q54757 (THIL_SYNE7)

Names and origin

Protein names

Recommended name:
    Thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	Synpcc7942_2567

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Thiamine-monophosphate kinase		PRO_0000096199

Sequences

	Sequence		Length	Mass (Da)
	Q54757-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E45C4D0307C644DA	FASTA	327	34,951
	10 20 30 40 50 60 MSDRSLSELG EQGLLPLLQA FCPAEQRGDD AAILTPPAGQ QLVVSSDVLV EGIHFSEATT 70 80 90 100 110 120 PPAAIGWRAA AANLSDLAAM GATPAGITLA LALPSDRRLS WLQQIYQGLD RCLKQYDCPL 130 140 150 160 170 180 IGGDLSRSPT ATLAVTALGW VNPNRVIRRS TAQVGDWIMA TGTHGLSRLG LGHLLGEWTL 190 200 210 220 230 240 AEPLRDQAIA AHQAPKPRLD VVPLLARSQP AGTVWRVAGM DSSDGLADAV LQICRASQVG 250 260 270 280 290 300 AVIEALPLPA TTSFDRDRLI QAALYGGEDF ELVLCLSPDW AQALLELLGE QAQVIGQITE 310 320 KPVVQLRLSD RTEILSLDRG FQHFTTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genes encoding biotin carboxyl carrier protein and elongation factor P from cyanobacterium Synechococcus sp. PCC 7942." Phung L.T., Haselkorn R. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59235 Genomic DNA. Translation: AAB82022.1. CP000100 Genomic DNA. Translation: ABB58597.1.
PIR	T30275.
RefSeq	YP_401584.1.
3D structure databases
SMR	Q54757. Positions 8-304.
ModBase	Search...
Protein-protein interaction databases
STRING	Q54757.
Genome annotation databases
GeneID	3775160.
GenomeReviews	Gene locus Synpcc7942_2567 in contig CP000100_GR.
KEGG	syf:Synpcc7942_2567.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0611.
HOGENOM	HBG577902.
Enzyme and pathway databases
BioCyc	SELO1140:SYNPCC7942_2567-MONOMER.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_SYNE7

Accession

Primary (citable) accession number: Q54757
Secondary accession number(s): Q31K22

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)