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Protein

Early growth response protein

Gene

EGR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response proteinUniRule annotation
Gene namesi
Name:EGR1Imported
ORF Names:hCG_18777Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000120738.7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27673.

Expressioni

Gene expression databases

BgeeiENSG00000120738.
ExpressionAtlasiQ546S1. baseline and differential.

Structurei

3D structure databases

SMRiQ546S1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini338 – 367C2H2-typeInterPro annotationAdd BLAST30
Domaini368 – 395C2H2-typeInterPro annotationAdd BLAST28
Domaini396 – 423C2H2-typeInterPro annotationAdd BLAST28

Sequence similaritiesi

Belongs to the EGR C2H2-type zinc-finger protein family.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG003909.
KOiK09203.
OMAiFATQTGS.
OrthoDBiEOG091G06VX.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR021839. DUF3432.
IPR021849. DUF3446.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF11914. DUF3432. 2 hits.
PF11928. DUF3446. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q546S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG
60 70 80 90 100
AAGAPEGSGS NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL
110 120 130 140 150
TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW
160 170 180 190 200
PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS SASASQSPPL SCAVPSNDSS
210 220 230 240 250
PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY PAAKGGFQVP
260 270 280 290 300
MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG
310 320 330 340 350
SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS
360 370 380 390 400
RSDELTRHIR IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI
410 420 430 440 450
CGRKFARSDE RKRHTKIHLR QKDKKADKSV VASSATSSLS SYPSPVATSY
460 470 480 490 500
PSPVTTSYPS PATTSYPSPV PTSFSSPGSS TYPSPVHSGF PSPSVATTYS
510 520 530 540
SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI EIC
Length:543
Mass (Da):57,507
Last modified:May 24, 2005 - v1
Checksum:i768CE670D9743E4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243425 Genomic DNA. Translation: CAB46678.1.
CH471062 Genomic DNA. Translation: EAW62135.1.
RefSeqiNP_001955.1. NM_001964.2.
UniGeneiHs.326035.
Hs.708393.

Genome annotation databases

GeneIDi1958.
KEGGihsa:1958.
UCSCiuc003ldb.2. human.

Similar proteinsi

Entry informationi

Entry nameiQ546S1_HUMAN
AccessioniPrimary (citable) accession number: Q546S1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.