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Q546L4

- Q546L4_MOUSE

UniProt

Q546L4 - Q546L4_MOUSE

Protein
Submitted name:

P2Y12 receptor

Gene

P2ry12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ADP receptor activity Source: MGI
    2. G-protein coupled adenosine receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
    2. calcium ion transmembrane transport Source: Ensembl
    3. cell projection organization Source: Ensembl
    4. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
    5. negative regulation of cell differentiation Source: Ensembl
    6. negative regulation of norepinephrine secretion Source: Ensembl
    7. platelet activation Source: MGI
    8. platelet aggregation Source: Ensembl
    9. positive regulation of ion transport Source: MGI
    10. potassium ion transmembrane transport Source: Ensembl
    11. protein kinase B signaling Source: Ensembl
    12. regulation of calcium ion transport Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    P2Y12 receptorImported
    Submitted name:
    Purinergic receptor P2Y, G-protein coupled 12, isoform CRA_aImported
    Gene namesi
    Name:P2ry12Imported
    ORF Names:mCG_13101Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1918089. P2ry12.

    Subcellular locationi

    GO - Cellular componenti

    1. basal plasma membrane Source: Ensembl
    2. caveola Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. integral component of plasma membrane Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ546L4.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG108228.
    InParanoidiQ546L4.
    KOiK04298.
    OMAiIKVFIII.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005394. P2Y12_rcpt.
    [Graphical view]
    PANTHERiPTHR24233:SF0. PTHR24233:SF0. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01569. P2Y12PRNCPTR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q546L4-1 [UniParc]FASTAAdd to Basket

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    MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS    50
    LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT 100
    LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL 150
    SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC 200
    QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV 250
    FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD 300
    PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM 347
    Length:347
    Mass (Da):39,474
    Last modified:May 24, 2005 - v1
    Checksum:iF107488E57E025F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312130 mRNA. Translation: CAC85296.1.
    CH466530 Genomic DNA. Translation: EDL35357.1.
    CH466530 Genomic DNA. Translation: EDL35358.1.
    RefSeqiNP_081847.3. NM_027571.3.
    XP_006502146.1. XM_006502083.1.
    XP_006502147.1. XM_006502084.1.
    XP_006502148.1. XM_006502085.1.
    UniGeneiMm.422675.

    Genome annotation databases

    GeneIDi70839.
    KEGGimmu:70839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ312130 mRNA. Translation: CAC85296.1 .
    CH466530 Genomic DNA. Translation: EDL35357.1 .
    CH466530 Genomic DNA. Translation: EDL35358.1 .
    RefSeqi NP_081847.3. NM_027571.3.
    XP_006502146.1. XM_006502083.1.
    XP_006502147.1. XM_006502084.1.
    XP_006502148.1. XM_006502085.1.
    UniGenei Mm.422675.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 70839.
    KEGGi mmu:70839.

    Organism-specific databases

    CTDi 64805.
    MGIi MGI:1918089. P2ry12.

    Phylogenomic databases

    HOVERGENi HBG108228.
    InParanoidi Q546L4.
    KOi K04298.
    OMAi IKVFIII.

    Miscellaneous databases

    NextBioi 332388.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q546L4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005394. P2Y12_rcpt.
    [Graphical view ]
    PANTHERi PTHR24233:SF0. PTHR24233:SF0. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01569. P2Y12PRNCPTR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional characterization of the mouse P2Y12 receptor."
      von Kugelgen I., Kulick M., Bonisch H., Bruss M.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ546L4_MOUSE
    AccessioniPrimary (citable) accession number: Q546L4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)