Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Purinergic receptor P2Y, G-protein coupled 12, isoform CRA_a

Gene

P2ry12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Purinergic receptor P2Y, G-protein coupled 12, isoform CRA_aImported
Submitted name:
p2Y12 receptorImported
Gene namesi
Name:P2ry12Imported
ORF Names:mCG_13101Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1918089 P2ry12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei108 – 126HelicalSequence analysisAdd BLAST19
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei195 – 219HelicalSequence analysisAdd BLAST25
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei290 – 308HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000036353
ExpressionAtlasiQ546L4 baseline and differential

Structurei

3D structure databases

SMRiQ546L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 304G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST257

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFYD Eukaryota
ENOG410ZJD1 LUCA
HOVERGENiHBG108228
KOiK04298
OMAiIKVFIII
OrthoDBiEOG091G0B3H

Family and domain databases

CDDicd15150 7tmA_P2Y12, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005394 P2Y12_rcpt
PANTHERiPTHR24233:SF0 PTHR24233:SF0, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01569 P2Y12PRNCPTR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q546L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS
60 70 80 90 100
LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT
110 120 130 140 150
LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL
160 170 180 190 200
SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC
210 220 230 240 250
QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV
260 270 280 290 300
FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD
310 320 330 340
PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM
Length:347
Mass (Da):39,474
Last modified:May 24, 2005 - v1
Checksum:iF107488E57E025F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312130 mRNA Translation: CAC85296.1
CH466530 Genomic DNA Translation: EDL35357.1
CH466530 Genomic DNA Translation: EDL35358.1
RefSeqiNP_081847.3, NM_027571.3
XP_006502146.1, XM_006502083.3
XP_006502147.1, XM_006502084.3
XP_006502148.1, XM_006502085.3
UniGeneiMm.422675

Genome annotation databases

GeneIDi70839
KEGGimmu:70839

Similar proteinsi

Entry informationi

Entry nameiQ546L4_MOUSE
AccessioniPrimary (citable) accession number: Q546L4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health