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Protein
Submitted name:

P2Y12 receptor

Gene

P2ry12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
P2Y12 receptorImported
Submitted name:
Purinergic receptor P2Y, G-protein coupled 12, isoform CRA_aImported
Gene namesi
Name:P2ry12Imported
ORF Names:mCG_13101Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1918089. P2ry12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei108 – 126HelicalSequence analysisAdd BLAST19
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei195 – 219HelicalSequence analysisAdd BLAST25
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei290 – 308HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000036353.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051353.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 304G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST257

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFYD. Eukaryota.
ENOG410ZJD1. LUCA.
HOVERGENiHBG108228.
KOiK04298.
OMAiIKVFIII.
OrthoDBiEOG091G0B3H.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF0. PTHR24233:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q546L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS
60 70 80 90 100
LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT
110 120 130 140 150
LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL
160 170 180 190 200
SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC
210 220 230 240 250
QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV
260 270 280 290 300
FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD
310 320 330 340
PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM
Length:347
Mass (Da):39,474
Last modified:May 24, 2005 - v1
Checksum:iF107488E57E025F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312130 mRNA. Translation: CAC85296.1.
CH466530 Genomic DNA. Translation: EDL35357.1.
CH466530 Genomic DNA. Translation: EDL35358.1.
RefSeqiNP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.3.
XP_006502147.1. XM_006502084.3.
XP_006502148.1. XM_006502085.3.
UniGeneiMm.422675.

Genome annotation databases

GeneIDi70839.
KEGGimmu:70839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312130 mRNA. Translation: CAC85296.1.
CH466530 Genomic DNA. Translation: EDL35357.1.
CH466530 Genomic DNA. Translation: EDL35358.1.
RefSeqiNP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.3.
XP_006502147.1. XM_006502084.3.
XP_006502148.1. XM_006502085.3.
UniGeneiMm.422675.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70839.
KEGGimmu:70839.

Organism-specific databases

CTDi64805.
MGIiMGI:1918089. P2ry12.

Phylogenomic databases

eggNOGiENOG410IFYD. Eukaryota.
ENOG410ZJD1. LUCA.
HOVERGENiHBG108228.
KOiK04298.
OMAiIKVFIII.
OrthoDBiEOG091G0B3H.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036353.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF0. PTHR24233:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ546L4_MOUSE
AccessioniPrimary (citable) accession number: Q546L4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.