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Q546L4

- Q546L4_MOUSE

UniProt

Q546L4 - Q546L4_MOUSE

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Protein
Submitted name:

P2Y12 receptor

Gene

P2ry12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ADP receptor activity Source: MGI
  2. G-protein coupled adenosine receptor activity Source: MGI

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  3. calcium ion transmembrane transport Source: Ensembl
  4. cell projection organization Source: Ensembl
  5. G-protein coupled purinergic nucleotide receptor signaling pathway Source: GOC
  6. negative regulation of cell differentiation Source: Ensembl
  7. negative regulation of norepinephrine secretion Source: Ensembl
  8. platelet activation Source: MGI
  9. platelet aggregation Source: Ensembl
  10. positive regulation of ion transport Source: MGI
  11. potassium ion transmembrane transport Source: Ensembl
  12. protein kinase B signaling Source: Ensembl
  13. regulation of calcium ion transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
P2Y12 receptorImported
Submitted name:
Purinergic receptor P2Y, G-protein coupled 12, isoform CRA_aImported
Gene namesi
Name:P2ry12Imported
ORF Names:mCG_13101Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1918089. P2ry12.

Subcellular locationi

GO - Cellular componenti

  1. basal plasma membrane Source: Ensembl
  2. caveola Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. integral component of plasma membrane Source: MGI
  5. mitochondrion Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ546L4.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG108228.
KOiK04298.
OMAiIKVFIII.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view]
PANTHERiPTHR24233:SF0. PTHR24233:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q546L4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS
60 70 80 90 100
LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT
110 120 130 140 150
LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL
160 170 180 190 200
SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC
210 220 230 240 250
QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV
260 270 280 290 300
FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD
310 320 330 340
PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM
Length:347
Mass (Da):39,474
Last modified:May 24, 2005 - v1
Checksum:iF107488E57E025F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312130 mRNA. Translation: CAC85296.1.
CH466530 Genomic DNA. Translation: EDL35357.1.
CH466530 Genomic DNA. Translation: EDL35358.1.
RefSeqiNP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.1.
XP_006502147.1. XM_006502084.1.
XP_006502148.1. XM_006502085.1.
UniGeneiMm.422675.

Genome annotation databases

GeneIDi70839.
KEGGimmu:70839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312130 mRNA. Translation: CAC85296.1 .
CH466530 Genomic DNA. Translation: EDL35357.1 .
CH466530 Genomic DNA. Translation: EDL35358.1 .
RefSeqi NP_081847.3. NM_027571.3.
XP_006502146.1. XM_006502083.1.
XP_006502147.1. XM_006502084.1.
XP_006502148.1. XM_006502085.1.
UniGenei Mm.422675.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 70839.
KEGGi mmu:70839.

Organism-specific databases

CTDi 64805.
MGIi MGI:1918089. P2ry12.

Phylogenomic databases

HOVERGENi HBG108228.
KOi K04298.
OMAi IKVFIII.

Miscellaneous databases

NextBioi 332388.
SOURCEi Search...

Gene expression databases

Genevestigatori Q546L4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005394. P2Y12_rcpt.
[Graphical view ]
PANTHERi PTHR24233:SF0. PTHR24233:SF0. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01569. P2Y12PRNCPTR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and functional characterization of the mouse P2Y12 receptor."
    von Kugelgen I., Kulick M., Bonisch H., Bruss M.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ546L4_MOUSE
AccessioniPrimary (citable) accession number: Q546L4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)