ID   Q546L3_MOUSE            Unreviewed;       290 AA.
AC   Q546L3;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   22-FEB-2023, entry version 120.
DE   RecName: Full=arylamine N-acetyltransferase {ECO:0000256|ARBA:ARBA00012701};
DE            EC=2.3.1.5 {ECO:0000256|ARBA:ARBA00012701};
GN   Name=Nat1 {ECO:0000313|EMBL:CAC85426.1, ECO:0000313|MGI:MGI:97279};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:CAC85426.1};
RN   [1] {ECO:0000313|EMBL:CAC85426.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Ola {ECO:0000313|EMBL:CAC85426.1}, CBA
RC   {ECO:0000313|EMBL:CAC85410.1}, PO {ECO:0000313|EMBL:CAC85411.1}, and
RC   TO {ECO:0000313|EMBL:CAC85412.1};
RX   PubMed=12142728; DOI=10.1097/00008571-200207000-00006;
RA   Boukouvala S., Price N., Sim E.;
RT   "Identification and functional characterization of novel polymorphisms
RT   associated with the genes for arylamine N-acetyltransferases in mice.";
RL   Pharmacogenetics 12:385-394(2002).
RN   [2] {ECO:0000313|EMBL:AAI19182.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI19182.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the arylamine N-acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006547, ECO:0000256|RuleBase:RU003452}.
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DR   EMBL; BC119181; AAI19182.1; -; mRNA.
DR   EMBL; BC137747; AAI37748.1; -; mRNA.
DR   EMBL; AJ314651; CAC85410.1; -; Genomic_DNA.
DR   EMBL; AJ314652; CAC85411.1; -; Genomic_DNA.
DR   EMBL; AJ314653; CAC85412.1; -; Genomic_DNA.
DR   EMBL; AJ314650; CAC85426.1; -; Genomic_DNA.
DR   RefSeq; NP_032699.1; NM_008673.1.
DR   AlphaFoldDB; Q546L3; -.
DR   SMR; Q546L3; -.
DR   DNASU; 17960; -.
DR   GeneID; 17960; -.
DR   KEGG; mmu:17960; -.
DR   AGR; MGI:97279; -.
DR   CTD; 9; -.
DR   MGI; MGI:97279; Nat1.
DR   VEuPathDB; HostDB:ENSMUSG00000025588; -.
DR   HOGENOM; CLU_049918_3_0_1; -.
DR   OrthoDB; 2696539at2759; -.
DR   BioGRID-ORCS; 17960; 2 hits in 76 CRISPR screens.
DR   ExpressionAtlas; Q546L3; baseline and differential.
DR   GO; GO:0004060; F:arylamine N-acetyltransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.2140.20; -; 1.
DR   InterPro; IPR001447; Arylamine_N-AcTrfase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   PANTHER; PTHR11786:SF2; ARYLAMINE N-ACETYLTRANSFERASE 1; 1.
DR   PANTHER; PTHR11786; N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE; 1.
DR   Pfam; PF00797; Acetyltransf_2; 1.
DR   PRINTS; PR01543; ANATRNSFRASE.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003452,
KW   ECO:0000313|EMBL:CAC85426.1};
KW   Transferase {ECO:0000256|RuleBase:RU003452, ECO:0000313|EMBL:CAC85426.1}.
SQ   SEQUENCE   290 AA;  33713 MW;  228C64130A2AD881 CRC64;
     MDIEAYFERI GYKNSVNKLD LATLTEVLQH QMRAVPFENL NMHCGEAMHL DLQDIFDHIV
     RKKRGGWCLQ VNHLLYWALT KMGFETTMLG GYVYITPVSK YSSEMVHLLV QVTISDRKYI
     VDSAYGGSYQ MWEPLELTSG KDQPQVPAIF LLTEENGTWY LDQIRREQYV PNEEFVNSDL
     LEKNKYRKIY SFTLEPRVIE DFEYVNSYLQ TSPASVFVST SFCSLQTSEG VHCLVGSTFT
     SRRFSYKDDV DLVEFKYVNE EEIEDVLKTA FGISLERKFV PKHGELVFTI
//