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Q546I3 (Q546I3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Peroxisome proliferator activated receptor beta/delta EMBL CAD44517.1
Gene names
Name:Ppard MGI 101884
Synonyms:PPARb/d EMBL CAD44517.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS000536
   Cellular componentNucleus SAAS SAAS000536
   DomainZinc-finger SAAS SAAS000536
   LigandDNA-binding SAAS SAAS000536
Metal-binding
Zinc
   Molecular functionReceptor EMBL CAD44517.1
Gene Ontology (GO)
   Biological_processadipose tissue development

Inferred from mutant phenotype PubMed 11756685. Source: MGI

anagen

Inferred from mutant phenotype PubMed 15713628. Source: MGI

apoptotic process

Inferred from electronic annotation. Source: Compara

axon ensheathment

Inferred from mutant phenotype PubMed 10866668. Source: MGI

cell differentiation

Inferred from direct assay PubMed 16581799. Source: MGI

cell-substrate adhesion

Inferred from mutant phenotype PubMed 11514592. Source: MGI

keratinocyte migration

Inferred from mutant phenotype PubMed 11514592. Source: MGI

keratinocyte proliferation

Inferred from mutant phenotype PubMed 11511099. Source: MGI

lipid metabolic process

Inferred from mutant phenotype PubMed 10866668PubMed 16581799. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 14758356. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8041794. Source: MGI

placenta development

Inferred from mutant phenotype PubMed 11756685. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 11756685. Source: MGI

positive regulation of phosphatidylinositol 3-kinase cascade

Inferred from direct assay PubMed 16581799. Source: MGI

positive regulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: Compara

regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 11756685. Source: MGI

wound healing

Inferred from mutant phenotype PubMed 11514592. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from direct assay PubMed 8041794. Source: MGI

drug binding

Inferred from electronic annotation. Source: Compara

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Traceable author statement PubMed 10866668. Source: MGI

linoleic acid binding

Inferred from electronic annotation. Source: Compara

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q546I3 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 58E0F595DD193FDA

FASTA44049,715
        10         20         30         40         50         60 
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP SSLLDQLQMG 

        70         80         90        100        110        120 
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLEYEKC DRICKIQKKN 

       130        140        150        160        170        180 
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH 

       190        200        210        220        230        240 
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI 

       250        260        270        280        290        300 
SVHVFYRCQS TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 

       310        320        330        340        350        360 
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR 

       370        380        390        400        410        420 
PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK 

       430        440 
KTESETLLHP LLQEIYKDMY

« Hide

References

[1]"Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency."
Larsen L.K., Amri E.Z., Mandrup S., Pacot C., Kristiansen K.
Biochem. J. 366:767-775(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57 Bl/6J EMBL CAD44517.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ420921, AJ420922 Genomic DNA. Translation: CAD44517.1.
IPIIPI00271799.
RefSeqNP_035275.1. NM_011145.3.
UniGeneMm.328914.

3D structure databases

ProteinModelPortalQ546I3.
SMRQ546I3. Positions 64-440.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ546I3.

Proteomic databases

PRIDEQ546I3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19015.
KEGGmmu:19015.
UCSCuc008bqk.1. mouse.

Organism-specific databases

CTD5467.
MGIMGI:101884. Ppard.

Phylogenomic databases

GeneTreeENSGT00700000104361.
HOVERGENHBG106004.
InParanoidQ546I3.
KOK04504.
OMASSLFLND.

Gene expression databases

ArrayExpressQ546I3.
GenevestigatorQ546I3.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. Str_ncl_receptor. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295440.
SOURCESearch...

Entry information

Entry nameQ546I3_MOUSE
AccessionPrimary (citable) accession number: Q546I3
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info