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Q546I3

- Q546I3_MOUSE

UniProt

Q546I3 - Q546I3_MOUSE

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Protein
Submitted name: Peroxisome proliferator activated receptor beta/delta
Gene
Ppard, PPARb/d
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. drug binding Source: Ensembl
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  4. linoleic acid binding Source: Ensembl
  5. sequence-specific DNA binding Source: InterPro
  6. steroid hormone receptor activity Source: InterPro
  7. transcription coactivator activity Source: Ensembl
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. adipose tissue development Source: MGI
  2. anagen Source: MGI
  3. apoptotic signaling pathway Source: Ensembl
  4. axon ensheathment Source: MGI
  5. cell differentiation Source: MGI
  6. cell proliferation Source: MGI
  7. cell-substrate adhesion Source: MGI
  8. cellular process Source: MGI
  9. cellular response to hypoxia Source: MGI
  10. decidualization Source: Ensembl
  11. embryo implantation Source: Ensembl
  12. epidermis development Source: MGI
  13. fatty acid oxidation Source: Ensembl
  14. heart development Source: Ensembl
  15. keratinocyte migration Source: MGI
  16. keratinocyte proliferation Source: MGI
  17. lipid metabolic process Source: MGI
  18. mRNA transcription Source: Ensembl
  19. negative regulation of apoptotic process Source: Ensembl
  20. negative regulation of cell growth Source: Ensembl
  21. negative regulation of collagen biosynthetic process Source: Ensembl
  22. negative regulation of epithelial cell proliferation Source: MGI
  23. negative regulation of inflammatory response Source: Ensembl
  24. negative regulation of smooth muscle cell migration Source: Ensembl
  25. negative regulation of smooth muscle cell proliferation Source: Ensembl
  26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  27. phospholipid biosynthetic process Source: Ensembl
  28. placenta development Source: MGI
  29. positive regulation of cell proliferation Source: MGI
  30. positive regulation of epidermis development Source: Ensembl
  31. positive regulation of insulin secretion Source: Ensembl
  32. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  33. positive regulation of transcription, DNA-templated Source: Ensembl
  34. positive regulation of vasodilation Source: Ensembl
  35. proteoglycan metabolic process Source: Ensembl
  36. regulation of cell proliferation Source: MGI
  37. regulation of fat cell differentiation Source: MGI
  38. response to activity Source: Ensembl
  39. response to glucose Source: Ensembl
  40. response to vitamin A Source: Ensembl
  41. vitamin A metabolic process Source: Ensembl
  42. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activated receptor beta/deltaImported
Gene namesi
Name:PpardImported
Synonyms:PPARb/dImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101884. Ppard.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

PTM / Processingi

Proteomic databases

PRIDEiQ546I3.

Expressioni

Gene expression databases

GenevestigatoriQ546I3.

Structurei

3D structure databases

ProteinModelPortaliQ546I3.
SMRiQ546I3. Positions 64-440.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115076.
HOVERGENiHBG106004.
InParanoidiQ546I3.
KOiK04504.
OMAiMNVPQVE.
PhylomeDBiQ546I3.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q546I3-1 [UniParc]FASTAAdd to Basket

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MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP    50
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA 150
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL 200
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS 250
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 300
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF 350
IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ 400
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY 440
Length:440
Mass (Da):49,715
Last modified:May 24, 2005 - v1
Checksum:i58E0F595DD193FDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ420921, AJ420922 Genomic DNA. Translation: CAD44517.1.
RefSeqiNP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGeneiMm.328914.

Genome annotation databases

GeneIDi19015.
KEGGimmu:19015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ420921 , AJ420922 Genomic DNA. Translation: CAD44517.1 .
RefSeqi NP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGenei Mm.328914.

3D structure databases

ProteinModelPortali Q546I3.
SMRi Q546I3. Positions 64-440.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q546I3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 19015.
KEGGi mmu:19015.

Organism-specific databases

CTDi 5467.
MGIi MGI:101884. Ppard.

Phylogenomic databases

GeneTreei ENSGT00740000115076.
HOVERGENi HBG106004.
InParanoidi Q546I3.
KOi K04504.
OMAi MNVPQVE.
PhylomeDBi Q546I3.

Miscellaneous databases

NextBioi 295440.
SOURCEi Search...

Gene expression databases

Genevestigatori Q546I3.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency."
    Larsen L.K., Amri E.Z., Mandrup S., Pacot C., Kristiansen K.
    Biochem. J. 366:767-775(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57 Bl/6JImported.

Entry informationi

Entry nameiQ546I3_MOUSE
AccessioniPrimary (citable) accession number: Q546I3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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