Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q546I3

- Q546I3_MOUSE

UniProt

Q546I3 - Q546I3_MOUSE

Protein
Submitted name:

Peroxisome proliferator activated receptor beta/delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. drug binding Source: Ensembl
    3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    4. linoleic acid binding Source: Ensembl
    5. sequence-specific DNA binding Source: InterPro
    6. steroid hormone receptor activity Source: InterPro
    7. transcription coactivator activity Source: Ensembl
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adipose tissue development Source: MGI
    2. anagen Source: MGI
    3. apoptotic signaling pathway Source: Ensembl
    4. axon ensheathment Source: MGI
    5. cell differentiation Source: MGI
    6. cell proliferation Source: MGI
    7. cell-substrate adhesion Source: MGI
    8. cellular process Source: MGI
    9. cellular response to hypoxia Source: MGI
    10. decidualization Source: Ensembl
    11. embryo implantation Source: Ensembl
    12. epidermis development Source: MGI
    13. fatty acid oxidation Source: Ensembl
    14. heart development Source: Ensembl
    15. keratinocyte migration Source: MGI
    16. keratinocyte proliferation Source: MGI
    17. lipid metabolic process Source: MGI
    18. mRNA transcription Source: Ensembl
    19. negative regulation of apoptotic process Source: Ensembl
    20. negative regulation of cell growth Source: Ensembl
    21. negative regulation of collagen biosynthetic process Source: Ensembl
    22. negative regulation of epithelial cell proliferation Source: MGI
    23. negative regulation of inflammatory response Source: Ensembl
    24. negative regulation of smooth muscle cell migration Source: Ensembl
    25. negative regulation of smooth muscle cell proliferation Source: Ensembl
    26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    27. phospholipid biosynthetic process Source: Ensembl
    28. placenta development Source: MGI
    29. positive regulation of cell proliferation Source: MGI
    30. positive regulation of epidermis development Source: Ensembl
    31. positive regulation of insulin secretion Source: Ensembl
    32. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    33. positive regulation of transcription, DNA-templated Source: Ensembl
    34. positive regulation of vasodilation Source: Ensembl
    35. proteoglycan metabolic process Source: Ensembl
    36. regulation of cell proliferation Source: MGI
    37. regulation of fat cell differentiation Source: MGI
    38. response to activity Source: Ensembl
    39. response to glucose Source: Ensembl
    40. response to vitamin A Source: Ensembl
    41. vitamin A metabolic process Source: Ensembl
    42. wound healing Source: MGI

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Peroxisome proliferator activated receptor beta/deltaImported
    Gene namesi
    Name:PpardImported
    Synonyms:PPARb/dImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:101884. Ppard.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ546I3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ546I3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ546I3.
    SMRiQ546I3. Positions 64-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115076.
    HOVERGENiHBG106004.
    InParanoidiQ546I3.
    KOiK04504.
    OMAiMNVPQVE.
    PhylomeDBiQ546I3.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003075. 1Cnucl_rcpt_B.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01290. PROXISOMPABR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q546I3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP    50
    SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
    IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA 150
    EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL 200
    TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS 250
    TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 300
    GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF 350
    IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ 400
    KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY 440
    Length:440
    Mass (Da):49,715
    Last modified:May 24, 2005 - v1
    Checksum:i58E0F595DD193FDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ420921, AJ420922 Genomic DNA. Translation: CAD44517.1.
    RefSeqiNP_035275.1. NM_011145.3.
    XP_006523922.1. XM_006523859.1.
    XP_006536796.1. XM_006536733.1.
    UniGeneiMm.328914.

    Genome annotation databases

    GeneIDi19015.
    KEGGimmu:19015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ420921 , AJ420922 Genomic DNA. Translation: CAD44517.1 .
    RefSeqi NP_035275.1. NM_011145.3.
    XP_006523922.1. XM_006523859.1.
    XP_006536796.1. XM_006536733.1.
    UniGenei Mm.328914.

    3D structure databases

    ProteinModelPortali Q546I3.
    SMRi Q546I3. Positions 64-440.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q546I3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 19015.
    KEGGi mmu:19015.

    Organism-specific databases

    CTDi 5467.
    MGIi MGI:101884. Ppard.

    Phylogenomic databases

    GeneTreei ENSGT00740000115076.
    HOVERGENi HBG106004.
    InParanoidi Q546I3.
    KOi K04504.
    OMAi MNVPQVE.
    PhylomeDBi Q546I3.

    Miscellaneous databases

    NextBioi 295440.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q546I3.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003075. 1Cnucl_rcpt_B.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01290. PROXISOMPABR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency."
      Larsen L.K., Amri E.Z., Mandrup S., Pacot C., Kristiansen K.
      Biochem. J. 366:767-775(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57 Bl/6JImported.

    Entry informationi

    Entry nameiQ546I3_MOUSE
    AccessioniPrimary (citable) accession number: Q546I3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)