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Protein
Submitted name:

Peroxisome proliferator activated receptor beta/delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: MGI
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: MGI
  • axon ensheathment Source: MGI
  • cell differentiation Source: MGI
  • cell proliferation Source: MGI
  • cell-substrate adhesion Source: MGI
  • cellular process Source: MGI
  • cellular response to hypoxia Source: MGI
  • decidualization Source: Ensembl
  • embryo implantation Source: MGI
  • epidermis development Source: MGI
  • fatty acid oxidation Source: Ensembl
  • heart development Source: Ensembl
  • intracellular receptor signaling pathway Source: MGI
  • keratinocyte migration Source: MGI
  • keratinocyte proliferation Source: MGI
  • lipid metabolic process Source: MGI
  • mRNA transcription Source: Ensembl
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of collagen biosynthetic process Source: Ensembl
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of inflammatory response Source: Ensembl
  • negative regulation of smooth muscle cell migration Source: Ensembl
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • phospholipid biosynthetic process Source: Ensembl
  • placenta development Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epidermis development Source: Ensembl
  • positive regulation of insulin secretion Source: Ensembl
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of vasodilation Source: Ensembl
  • proteoglycan metabolic process Source: Ensembl
  • regulation of cell proliferation Source: MGI
  • regulation of fat cell differentiation Source: MGI
  • response to activity Source: Ensembl
  • response to glucose Source: Ensembl
  • response to vitamin A Source: Ensembl
  • vitamin A metabolic process Source: Ensembl
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activated receptor beta/deltaImported
Gene namesi
Name:PpardImported
Synonyms:PPARb/dImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101884. Ppard.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ546I3.

Expressioni

Gene expression databases

BgeeiQ546I3.
ExpressionAtlasiQ546I3. baseline and differential.
GenevisibleiQ546I3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002320.

Structurei

3D structure databases

ProteinModelPortaliQ546I3.
SMRiQ546I3. Positions 64-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOVERGENiHBG106004.
KOiK04504.
OMAiMNVPQVE.
PhylomeDBiQ546I3.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q546I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP
60 70 80 90 100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA
160 170 180 190 200
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL
210 220 230 240 250
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS
260 270 280 290 300
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
310 320 330 340 350
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF
360 370 380 390 400
IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ
410 420 430 440
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY
Length:440
Mass (Da):49,715
Last modified:May 24, 2005 - v1
Checksum:i58E0F595DD193FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ420921, AJ420922 Genomic DNA. Translation: CAD44517.1.
RefSeqiNP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGeneiMm.328914.

Genome annotation databases

GeneIDi19015.
KEGGimmu:19015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ420921, AJ420922 Genomic DNA. Translation: CAD44517.1.
RefSeqiNP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGeneiMm.328914.

3D structure databases

ProteinModelPortaliQ546I3.
SMRiQ546I3. Positions 64-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002320.

Chemistry

BindingDBiQ546I3.

Proteomic databases

PRIDEiQ546I3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19015.
KEGGimmu:19015.

Organism-specific databases

CTDi5467.
MGIiMGI:101884. Ppard.

Phylogenomic databases

GeneTreeiENSGT00780000121834.
HOVERGENiHBG106004.
KOiK04504.
OMAiMNVPQVE.
PhylomeDBiQ546I3.

Miscellaneous databases

NextBioi295440.
SOURCEiSearch...

Gene expression databases

BgeeiQ546I3.
ExpressionAtlasiQ546I3. baseline and differential.
GenevisibleiQ546I3. MM.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency."
    Larsen L.K., Amri E.Z., Mandrup S., Pacot C., Kristiansen K.
    Biochem. J. 366:767-775(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57 Bl/6JImported.

Entry informationi

Entry nameiQ546I3_MOUSE
AccessioniPrimary (citable) accession number: Q546I3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 24, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.