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Q546I3 (Q546I3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Ppard MGI 101884
Synonyms:PPARb/d EMBL CAD44517.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains nuclear receptor DNA-binding domain. SAAS SAAS001723

Ontologies

Keywords
   Biological processTranscription
Transcription regulation RuleBase RU004334 SAAS SAAS001723
   Cellular componentNucleus RuleBase RU004334 SAAS SAAS001723
   DomainZinc-finger RuleBase RU004334 SAAS SAAS001723
   LigandDNA-binding RuleBase RU004334 SAAS SAAS001723
Metal-binding
Zinc
   Molecular functionReceptor RuleBase RU004334 EMBL CAD44517.1
Gene Ontology (GO)
   Biological_processadipose tissue development

Inferred from mutant phenotype PubMed 11756685. Source: MGI

anagen

Inferred from mutant phenotype PubMed 15713628. Source: MGI

apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

axon ensheathment

Inferred from mutant phenotype PubMed 10866668. Source: MGI

cell differentiation

Inferred from direct assay PubMed 16581799. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 10866668. Source: MGI

cell-substrate adhesion

Inferred from mutant phenotype PubMed 11514592. Source: MGI

cellular process

Traceable author statement PubMed 10866668. Source: MGI

cellular response to hypoxia

Inferred from genetic interaction PubMed 24011070. Source: MGI

decidualization

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from electronic annotation. Source: Ensembl

epidermis development

Traceable author statement PubMed 10866668. Source: MGI

fatty acid oxidation

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

keratinocyte migration

Inferred from mutant phenotype PubMed 11514592. Source: MGI

keratinocyte proliferation

Inferred from mutant phenotype PubMed 11511099. Source: MGI

lipid metabolic process

Inferred from mutant phenotype PubMed 10866668PubMed 16581799. Source: MGI

mRNA transcription

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 14758356. Source: MGI

negative regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8041794. Source: MGI

phospholipid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

placenta development

Inferred from mutant phenotype PubMed 11756685. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 11756685. Source: MGI

positive regulation of epidermis development

Inferred from electronic annotation. Source: Ensembl

positive regulation of insulin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from direct assay PubMed 16581799. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

proteoglycan metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of cell proliferation

Inferred from genetic interaction PubMed 15380519. Source: MGI

regulation of fat cell differentiation

Inferred from mutant phenotype PubMed 11756685. Source: MGI

response to activity

Inferred from electronic annotation. Source: Ensembl

response to glucose

Inferred from electronic annotation. Source: Ensembl

response to vitamin A

Inferred from electronic annotation. Source: Ensembl

vitamin A metabolic process

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from mutant phenotype PubMed 11514592. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from direct assay PubMed 8041794. Source: MGI

drug binding

Inferred from electronic annotation. Source: Ensembl

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

Traceable author statement PubMed 10866668. Source: MGI

linoleic acid binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q546I3 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 58E0F595DD193FDA

FASTA44049,715
        10         20         30         40         50         60 
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP SSLLDQLQMG 

        70         80         90        100        110        120 
CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT IRMKLEYEKC DRICKIQKKN 

       130        140        150        160        170        180 
RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH 

       190        200        210        220        230        240 
IYNAYLKNFN MTKKKARSIL TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI 

       250        260        270        280        290        300 
SVHVFYRCQS TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 

       310        320        330        340        350        360 
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF IAAIILCGDR 

       370        380        390        400        410        420 
PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ KMADLRQLVT EHAQMMQWLK 

       430        440 
KTESETLLHP LLQEIYKDMY 

« Hide

References

[1]"Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency."
Larsen L.K., Amri E.Z., Mandrup S., Pacot C., Kristiansen K.
Biochem. J. 366:767-775(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57 Bl/6J EMBL CAD44517.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ420921, AJ420922 Genomic DNA. Translation: CAD44517.1.
RefSeqNP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGeneMm.328914.

3D structure databases

ProteinModelPortalQ546I3.
SMRQ546I3. Positions 64-440.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ546I3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19015.
KEGGmmu:19015.

Organism-specific databases

CTD5467.
MGIMGI:101884. Ppard.

Phylogenomic databases

GeneTreeENSGT00740000115076.
HOVERGENHBG106004.
InParanoidQ546I3.
KOK04504.
OMAMNVPQVE.
PhylomeDBQ546I3.

Gene expression databases

GenevestigatorQ546I3.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295440.
SOURCESearch...

Entry information

Entry nameQ546I3_MOUSE
AccessionPrimary (citable) accession number: Q546I3
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)