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Protein
Submitted name:

Kallikrein 3, (Prostate specific antigen), isoform CRA_m

Gene

KLK3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Kallikrein 3, (Prostate specific antigen), isoform CRA_mImported
Submitted name:
Kallikrein A2Imported
Submitted name:
Prostate specific antigenImported
Submitted name:
cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNAImported
Gene namesi
Name:KLK3Imported
Synonyms:KLNA2Imported
ORF Names:hCG_22929Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000142515.14

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164741810

Protein family/group databases

Allergomei2836 Hom s PSA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501430958618 – 261Sequence analysisAdd BLAST244

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ546G3

Expressioni

Gene expression databases

BgeeiENSG00000142515
ExpressionAtlasiQ546G3 baseline and differential

Structurei

3D structure databases

SMRiQ546G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1InterPro annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOVERGENiHBG013304
KOiK01351

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q546G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC
60 70 80 90 100
GGVLVHPQWV LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL
110 120 130 140 150
YDMSLLKNRF LRPGDDSSHD LMLLRLSEPA ELTDAVKVMD LPTQEPALGT
160 170 180 190 200
TCYASGWGSI EPEEFLTPKK LQCVDLHVIS NDVCAQVHPQ KVTKFMLCAG
210 220 230 240 250
RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP SLYTKVVHYR
260
KWIKDTIVAN P
Length:261
Mass (Da):28,741
Last modified:May 24, 2005 - v1
Checksum:iAE9E732AF872141A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312933 mRNA Translation: BAG35776.1
AJ459783 mRNA Translation: CAD30845.1
CH471135 Genomic DNA Translation: EAW71935.1
LT631551 Genomic DNA Translation: SFW93198.1
RefSeqiNP_001639.1, NM_001648.2
UniGeneiHs.171995

Genome annotation databases

GeneIDi354
KEGGihsa:354
UCSCiuc021uyi.2 human

Similar proteinsi

Entry informationi

Entry nameiQ546G3_HUMAN
AccessioniPrimary (citable) accession number: Q546G3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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