Q546G3 (Q546G3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Kallikrein 3, (Prostate specific antigen), isoform CRA_m EMBL EAW71935.1

Submitted name:
Prostate specific antigen EMBL CAD30845.1
Submitted name:
cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNA EMBL BAG35776.1

Gene names

Name:	KLK3 EMBL CAD30845.1
ORF Names:	hCG_22929 EMBL EAW71935.1

Organism

Homo sapiens (Human) EMBL CAD30845.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase S1 family. RuleBase RU000360

Ontologies

Keywords
Domain	Signal EMBL CAD30845.1
Molecular function	Hydrolase Protease Serine protease RuleBase RU004260
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential EMBL CAD30845.1
	Chain	18 – 261	244	Potential EMBL CAD30845.1		PRO_5000068522
	Chain	25 – 261	237	prostate specific antigen EMBL CAD30845.1		PRO_5000068523

Sequences

	Sequence		Length	Mass (Da)
	Q546G3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: AE9E732AF872141A	FASTA	261	28,741
	10 20 30 40 50 60 MWVPVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC GGVLVHPQWV 70 80 90 100 110 120 LTAAHCIRNK SVILLGRHSL FHPEDTGQVF QVSHSFPHPL YDMSLLKNRF LRPGDDSSHD 130 140 150 160 170 180 LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI EPEEFLTPKK LQCVDLHVIS 190 200 210 220 230 240 NDVCAQVHPQ KVTKFMLCAG RWTGGKSTCS GDSGGPLVCN GVLQGITSWG SEPCALPERP 250 260 SLYTKVVHYR KWIKDTIVAN P

References

[1]	"Complex alternative splicing of the hKLK3 gene coding for the tumour marker PSA (prostate-specific-antigen)." Heuze-Vourc'h N., Courty Y. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Prostate EMBL CAD30845.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Prostate EMBL BAG35776.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK312933 mRNA. Translation: BAG35776.1. AJ459783 mRNA. Translation: CAD30845.1. CH471135 Genomic DNA. Translation: EAW71935.1.
IPI	IPI00010858.
RefSeq	NP_001639.1. NM_001648.2.
UniGene	Hs.171995.
3D structure databases
ProteinModelPortal	Q546G3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q546G3.
Protein family/group databases
Allergome	2836. Hom s PSA.
Proteomic databases
PRIDE	Q546G3.
Protocols and materials databases
DNASU	354.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	354.
KEGG	hsa:354.
Organism-specific databases
CTD	354.
PharmGKB	PA164741810.
Phylogenomic databases
HOVERGEN	HBG013304.
KO	K01351.
OMA	EDIMIAN.
PhylomeDB	Q546G3.
Gene expression databases
ArrayExpress	Q546G3.
Bgee	Q546G3.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KLK3. human.
GenomeRNAi	354.
NextBio	1459.

Entry information

Entry name

Q546G3_HUMAN

Accession

Primary (citable) accession number: Q546G3

Entry history

Integrated into UniProtKB/TrEMBL:	May 24, 2005
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.