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Protein

Alpha-(1,6)-fucosyltransferase

Gene

FUT8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.UniRule annotation

Catalytic activityi

GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT23. Glycosyltransferase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,6)-fucosyltransferaseUniRule annotation (EC:2.4.1.68UniRule annotation)
Gene namesi
Name:FUT8Imported
ORF Names:hCG_22125Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Golgi apparatusGolgi stack membrane UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3019HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28435.

Expressioni

Gene expression databases

BgeeiENSG00000033170.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353910.

Structurei

3D structure databases

SMRiQ546E0. Positions 108-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 493288GT23InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili43 – 7028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 23 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3705. Eukaryota.
ENOG410YHM8. LUCA.
HOVERGENiHBG028260.
KOiK00717.
OMAiNARKLVC.
OrthoDBiEOG091G05GD.
PhylomeDBiQ546E0.

Family and domain databases

InterProiIPR015827. Alpha1_6FUT_euk.
IPR027350. GT23_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51659. GT23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q546E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL
60 70 80 90 100
ERLKQQNEDL RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY
110 120 130 140 150
KKQTRNGLGK DHEILRRRIE NGAKELWFFL QSELKKLKNL EGNELQRHAD
160 170 180 190 200
EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR EKEAKDLTEL VQRRITYLQN
210 220 230 240 250
PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT LILESQNWRY
260 270 280 290 300
ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR
310 320 330 340 350
PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT
360 370 380 390 400
KKLGFKHPVI GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD
410 420 430 440 450
KKRVYLATDD PSLLKEAKTK YPNYEFISDN SISWSAGLHN RYTENSLRGV
460 470 480 490 500
ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ TLHPDASANF HSLDDIYYFG
510 520 530 540 550
GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS KGVNRKLGRT
560 570
GLYPSYKVRE KIETVKYPTY PEAEK
Length:575
Mass (Da):66,516
Last modified:May 24, 2005 - v1
Checksum:i5AE24A93881E18D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536053 mRNA. Translation: CAD59924.1.
AJ536054 mRNA. Translation: CAD59925.1.
AJ536055 mRNA. Translation: CAD59926.1.
AJ536056 mRNA. Translation: CAD59927.1.
AJ539535 mRNA. Translation: CAD62444.1.
AJ539536 mRNA. Translation: CAD62445.1.
CH471061 Genomic DNA. Translation: EAW80913.1.
CH471061 Genomic DNA. Translation: EAW80915.1.
CH471061 Genomic DNA. Translation: EAW80916.1.
CH471061 Genomic DNA. Translation: EAW80917.1.
RefSeqiNP_004471.4. NM_004480.4.
NP_835368.1. NM_178155.2.
NP_835369.1. NM_178156.2.
UniGeneiHs.597649.
Hs.654961.

Genome annotation databases

GeneIDi2530.
KEGGihsa:2530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536053 mRNA. Translation: CAD59924.1.
AJ536054 mRNA. Translation: CAD59925.1.
AJ536055 mRNA. Translation: CAD59926.1.
AJ536056 mRNA. Translation: CAD59927.1.
AJ539535 mRNA. Translation: CAD62444.1.
AJ539536 mRNA. Translation: CAD62445.1.
CH471061 Genomic DNA. Translation: EAW80913.1.
CH471061 Genomic DNA. Translation: EAW80915.1.
CH471061 Genomic DNA. Translation: EAW80916.1.
CH471061 Genomic DNA. Translation: EAW80917.1.
RefSeqiNP_004471.4. NM_004480.4.
NP_835368.1. NM_178155.2.
NP_835369.1. NM_178156.2.
UniGeneiHs.597649.
Hs.654961.

3D structure databases

SMRiQ546E0. Positions 108-572.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353910.

Protein family/group databases

CAZyiGT23. Glycosyltransferase Family 23.

Protocols and materials databases

DNASUi2530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2530.
KEGGihsa:2530.

Organism-specific databases

CTDi2530.
PharmGKBiPA28435.

Phylogenomic databases

eggNOGiKOG3705. Eukaryota.
ENOG410YHM8. LUCA.
HOVERGENiHBG028260.
KOiK00717.
OMAiNARKLVC.
OrthoDBiEOG091G05GD.
PhylomeDBiQ546E0.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

ChiTaRSiFUT8. human.
GenomeRNAii2530.

Gene expression databases

BgeeiENSG00000033170.

Family and domain databases

InterProiIPR015827. Alpha1_6FUT_euk.
IPR027350. GT23_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51659. GT23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ546E0_HUMAN
AccessioniPrimary (citable) accession number: Q546E0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.