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Protein

Alpha-(1,6)-fucosyltransferase

Gene

FUT8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.UniRule annotation

Catalytic activityi

GDP-beta-L-fucose + N4-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N4-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT23 Glycosyltransferase Family 23

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,6)-fucosyltransferaseUniRule annotation (EC:2.4.1.68UniRule annotation)
Gene namesi
Name:FUT8Imported
ORF Names:hCG_22125Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000033170.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 30HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28435

PTM / Processingi

Proteomic databases

PRIDEiQ546E0

Expressioni

Gene expression databases

BgeeiENSG00000033170
ExpressionAtlasiQ546E0 baseline and differential

Structurei

3D structure databases

SMRiQ546E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 493GT23InterPro annotationAdd BLAST288
Domaini502 – 563SH3InterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili43 – 70Sequence analysisAdd BLAST28
Coiled coili83 – 103Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the glycosyltransferase 23 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3705 Eukaryota
ENOG410YHM8 LUCA
HOVERGENiHBG028260
KOiK00717
OMAiVCKLNKG
OrthoDBiEOG091G05GD

Family and domain databases

CDDicd11792 SH3_Fut8, 1 hit
InterProiView protein in InterPro
IPR015827 Fut8
IPR035653 Fut8_SH3
IPR027350 GT23_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF14604 SH3_9, 1 hit
PIRSFiPIRSF000472 Alpha1_6FUT_euk, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51659 GT23, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q546E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL
60 70 80 90 100
ERLKQQNEDL RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY
110 120 130 140 150
KKQTRNGLGK DHEILRRRIE NGAKELWFFL QSELKKLKNL EGNELQRHAD
160 170 180 190 200
EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR EKEAKDLTEL VQRRITYLQN
210 220 230 240 250
PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT LILESQNWRY
260 270 280 290 300
ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR
310 320 330 340 350
PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT
360 370 380 390 400
KKLGFKHPVI GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD
410 420 430 440 450
KKRVYLATDD PSLLKEAKTK YPNYEFISDN SISWSAGLHN RYTENSLRGV
460 470 480 490 500
ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ TLHPDASANF HSLDDIYYFG
510 520 530 540 550
GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS KGVNRKLGRT
560 570
GLYPSYKVRE KIETVKYPTY PEAEK
Length:575
Mass (Da):66,516
Last modified:May 24, 2005 - v1
Checksum:i5AE24A93881E18D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ536053 mRNA Translation: CAD59924.1
AJ536054 mRNA Translation: CAD59925.1
AJ536055 mRNA Translation: CAD59926.1
AJ536056 mRNA Translation: CAD59927.1
AJ539535 mRNA Translation: CAD62444.1
AJ539536 mRNA Translation: CAD62445.1
CH471061 Genomic DNA Translation: EAW80913.1
CH471061 Genomic DNA Translation: EAW80915.1
CH471061 Genomic DNA Translation: EAW80916.1
CH471061 Genomic DNA Translation: EAW80917.1
RefSeqiNP_004471.4, NM_004480.4
NP_835368.1, NM_178155.2
NP_835369.1, NM_178156.2
UniGeneiHs.597649
Hs.654961

Genome annotation databases

GeneIDi2530
KEGGihsa:2530

Similar proteinsi

Entry informationi

Entry nameiQ546E0_HUMAN
AccessioniPrimary (citable) accession number: Q546E0
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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