Satb2

Functionⁱ

GO - Molecular functionⁱ

RNA polymerase II core promoter proximal region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 16751105
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 16751105

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotation
Biological process	Transcription, Transcription regulationUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA-binding protein SATBUniRule annotation Alternative name(s): Special AT-rich sequence-binding proteinUniRule annotation
Gene namesⁱ	Name:Satb2Imported Synonyms:SATB2Imported ORF Names:mCG_113907Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:2679336. Satb2.

Subcellular locationⁱ

Nucleus
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU000682

GO - Cellular componentⁱ

nucleoplasm Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000038331.
ExpressionAtlasⁱ	Q546B3. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q546B3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	350 – 437	CUT DNA-bindingInterPro annotationAdd BLAST	88
Domainⁱ	473 – 560	CUT DNA-bindingInterPro annotationAdd BLAST	88
Domainⁱ	612 – 673	Homeobox DNA-bindingInterPro annotationAdd BLAST	62

Sequence similaritiesⁱ

Belongs to the CUT homeobox family.UniRule annotation

Keywords - Domainⁱ

HomeoboxUniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410ISJ9. Eukaryota. ENOG41113K2. LUCA.
HOVERGENⁱ	HBG054240.
OMAⁱ	CVVEQSD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02HV.

Family and domain databases

InterProⁱ	View protein in InterPro IPR003350. CUT_dom. IPR032355. CUTL. IPR009057. Homeobox-like. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom. IPR032392. ULD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02376. CUT. 2 hits. PF16557. CUTL. 1 hit. PF00046. Homeobox. 1 hit. PF16534. ULD. 1 hit.
SMARTⁱ	View protein in SMART SM01109. CUT. 2 hits. SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 2 hits.
PROSITEⁱ	View protein in PROSITE PS51042. CUT. 2 hits. PS50071. HOMEOBOX_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q546B3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA 
        60         70         80         90        100
VAKAVGGLMI PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA 
       110        120        130        140        150
LLALGYSHSS AAQAQGIIKL GRWNPLPLSY VTDAPDATVA DMLQDVYHVV 
       160        170        180        190        200
TLKIQLQSCS KLEDLPAEQW NHATVRNALK ELLKEMNQST LAKECPLSQS 
       210        220        230        240        250
MISSIVNSTY YANVSATKCQ EFGRWYKKYK KIKVERVERE NLSDYCVLGQ 
       260        270        280        290        300
RPMHLPNMNQ LASLGKTNEQ SPHSQIHHST PIRNQVPALQ PIMSPGLLSP 
       310        320        330        340        350
QLSPQLVRQQ IAMAHLINQQ IAVSRLLAHQ HPQAINQQFL NHPPIPRAVK 
       360        370        380        390        400
PEPTNSSVEV SPDIYQQVRD ELKRASVSQA VFARVAFNRT QGLLSEILRK 
       410        420        430        440        450
EEDPRTASQS LLVNLRAMQN FLNLPEVERD RIYQDERERS MNPNVSMVSS 
       460        470        480        490        500
ASSSPSSSRT PQAKTSTPTT DLPIKVDGAN VNITAAIYDE IQQEMKRAKV 
       510        520        530        540        550
SQALFAKVAA NKSQGWLCEL LRWKENPSPE NRTLWENLCT IRRFLNLPQH 
       560        570        580        590        600
ERDVIYEEES RHHHSERMQH VVQLPPEPVQ VLHRQQSQPT KESSPPREEA 
       610        620        630        640        650
PPPPPPTEDS CAKKPRSRTK ISLEALGILQ SFIHDVGLYP DQEAIHTLSA 
       660        670        680        690        700
QLDLPKHTII KFFQNQRYHV KHHGKLKEHL GSAVDVAEYK DEELLTESEE 
       710        720        730 
NDSEEGSEEM YKVEAEEENA DKSKAAPAET DQR

Length:733

Mass (Da):82,559

Last modified:May 24, 2005 - v1

Checksum:ⁱ153CFD1CC3491F25

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC138625 mRNA. Translation: AAI38626.1. BC138626 mRNA. Translation: AAI38627.1. AJ606045 mRNA. Translation: CAE54289.1. CH466548 Genomic DNA. Translation: EDL00043.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_631885.1. NM_139146.2. XP_017175119.1. XM_017319630.1. XP_017175120.1. XM_017319631.1.
UniGeneⁱ	Mm.145599.

Genome annotation databases

GeneIDⁱ	212712.
KEGGⁱ	mmu:212712.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC138625 mRNA. Translation: AAI38626.1. BC138626 mRNA. Translation: AAI38627.1. AJ606045 mRNA. Translation: CAE54289.1. CH466548 Genomic DNA. Translation: EDL00043.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_631885.1. NM_139146.2. XP_017175119.1. XM_017319630.1. XP_017175120.1. XM_017319631.1.
UniGeneⁱ	Mm.145599.

3D structure databases

SMRⁱ	Q546B3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	212712.
KEGGⁱ	mmu:212712.

Organism-specific databases

CTDⁱ	23314.
MGIⁱ	MGI:2679336. Satb2.

Phylogenomic databases

eggNOGⁱ	ENOG410ISJ9. Eukaryota. ENOG41113K2. LUCA.
HOVERGENⁱ	HBG054240.
OMAⁱ	CVVEQSD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02HV.

Miscellaneous databases

ChiTaRSⁱ	Satb2. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038331.
ExpressionAtlasⁱ	Q546B3. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR003350. CUT_dom. IPR032355. CUTL. IPR009057. Homeobox-like. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom. IPR032392. ULD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02376. CUT. 2 hits. PF16557. CUTL. 1 hit. PF00046. Homeobox. 1 hit. PF16534. ULD. 1 hit.
SMARTⁱ	View protein in SMART SM01109. CUT. 2 hits. SM00389. HOX. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 2 hits.
PROSITEⁱ	View protein in PROSITE PS51042. CUT. 2 hits. PS50071. HOMEOBOX_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q546B3_MOUSE
Accessionⁱ	Q546B3Primary (citable) accession number: Q546B3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 24, 2005
	Last sequence update:	May 24, 2005
	Last modified:	July 5, 2017
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q546B3 (Q546B3_MOUSE)

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DNA-binding protein SATB

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Functionⁱ

GO - Molecular functionⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q546B3 (Q546B3_MOUSE)

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DNA-binding protein SATB

Satb2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ