ID HYLP2_BPH45 Reviewed; 337 AA. AC Q54699; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 08-NOV-2023, entry version 62. DE RecName: Full=Hyaluronoglucosaminidase; DE Short=Hyaluronidase; DE EC=3.2.1.35; GN Name=HYLP2; OS Streptococcus pyogenes phage H10403. OC Viruses. OX NCBI_TaxID=86065; OH NCBI_TaxID=1314; Streptococcus pyogenes. RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=7622224; DOI=10.1128/iai.63.8.3015-3020.1995; RA Hynes W.L., Hancock L., Ferretti J.J.; RT "Analysis of a second bacteriophage hyaluronidase gene from Streptococcus RT pyogenes: evidence for a third hyaluronidase involved in extracellular RT enzymatic activity."; RL Infect. Immun. 63:3015-3020(1995). CC -!- FUNCTION: The hyaluronidase of this bacteriophage mediates the CC penetration of the hyaluronic capsule of Streptococcus pyogenes. CC -!- CATALYTIC ACTIVITY: CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D- CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35; CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 69 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U28144; AAA86895.1; -; Genomic_DNA. DR SMR; Q54699; -. DR CAZy; PL16; Polysaccharide Lyase Family 16. DR BRENDA; 3.2.1.36; 8503. DR SABIO-RK; Q54699; -. DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW. DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-EC. DR GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:InterPro. DR GO; GO:0098994; P:disruption of host cell envelope during viral entry; IEA:UniProtKB-KW. DR GO; GO:0098996; P:disruption of host cell glycocalyx during viral entry; IEA:UniProtKB-KW. DR InterPro; IPR009860; Hyaluronidase_bac. DR InterPro; IPR041352; Mtd_N. DR Pfam; PF07212; Hyaluronidase_1; 1. DR Pfam; PF18454; Mtd_N; 1. DR SUPFAM; SSF69349; Phage fibre proteins; 1. PE 3: Inferred from homology; KW Degradation of host capsule during virus entry; KW Degradation of host cell envelope components during virus entry; KW Glycosidase; Hydrolase; Virion; Virus entry into host cell. FT CHAIN 1..337 FT /note="Hyaluronoglucosaminidase" FT /id="PRO_0000057724" SQ SEQUENCE 337 AA; 36453 MW; 770EB8E6B7F9D842 CRC64; MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS DLGYISPLDY NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE LDKKLNLKGG VMTGQLKFKP AATVAYSSST GGAVNIDLSS TRGAGVVVYS DNDTSDGPLM SLRTGKETFN QSALFVDYKG TTNAVNIAMR HATTPNFSSA LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK NAARYPLILS KRQNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK //