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Q54699 (HYLP2_BPH45) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronoglucosaminidase

Short name=Hyaluronidase
EC=3.2.1.35
Gene names
Name:HYLP2
OrganismStreptococcus pyogenes phage H10403
Taxonomic identifier86065 [NCBI]
Taxonomic lineageVirusesunclassified phages
Virus hostStreptococcus pyogenes [TaxID: 1314]

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sequence similarities

Belongs to the glycosyl hydrolase 69 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcapsule polysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Hyaluronoglucosaminidase
PRO_0000057724

Sequences

Sequence LengthMass (Da)Tools
Q54699 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 770EB8E6B7F9D842

FASTA33736,453
        10         20         30         40         50         60 
MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS DLGYISPLDY 

        70         80         90        100        110        120 
NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE LDKKLNLKGG VMTGQLKFKP 

       130        140        150        160        170        180 
AATVAYSSST GGAVNIDLSS TRGAGVVVYS DNDTSDGPLM SLRTGKETFN QSALFVDYKG 

       190        200        210        220        230        240 
TTNAVNIAMR HATTPNFSSA LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK 

       250        260        270        280        290        300 
NAARYPLILS KRQNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS 

       310        320        330 
QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK 

« Hide

References

[1]"Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity."
Hynes W.L., Hancock L., Ferretti J.J.
Infect. Immun. 63:3015-3020(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28144 Genomic DNA. Translation: AAA86895.1.

3D structure databases

ProteinModelPortalQ54699.
SMRQ54699. Positions 7-337.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyPL16. Polysaccharide Lyase Family 16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKQ54699.

Family and domain databases

InterProIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHYLP2_BPH45
AccessionPrimary (citable) accession number: Q54699
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries