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Q54699

- HYLP2_BPH45

UniProt

Q54699 - HYLP2_BPH45

Protein

Hyaluronoglucosaminidase

Gene

HYLP2

Organism
Streptococcus pyogenes phage H10403
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    GO - Molecular functioni

    1. hyalurononglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    SABIO-RKQ54699.

    Protein family/group databases

    CAZyiPL16. Polysaccharide Lyase Family 16.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronoglucosaminidase (EC:3.2.1.35)
    Short name:
    Hyaluronidase
    Gene namesi
    Name:HYLP2
    OrganismiStreptococcus pyogenes phage H10403
    Taxonomic identifieri86065 [NCBI]
    Taxonomic lineageiVirusesunclassified phages
    Virus hostiStreptococcus pyogenes [TaxID: 1314]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337HyaluronoglucosaminidasePRO_0000057724Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ54699.
    SMRiQ54699. Positions 7-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 69 family.Curated

    Family and domain databases

    InterProiIPR009860. Hyaluronidase_bac.
    [Graphical view]
    PfamiPF07212. Hyaluronidase_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q54699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS    50
    DLGYISPLDY NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE 100
    LDKKLNLKGG VMTGQLKFKP AATVAYSSST GGAVNIDLSS TRGAGVVVYS 150
    DNDTSDGPLM SLRTGKETFN QSALFVDYKG TTNAVNIAMR HATTPNFSSA 200
    LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK NAARYPLILS 250
    KRQNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS 300
    QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK 337
    Length:337
    Mass (Da):36,453
    Last modified:November 1, 1996 - v1
    Checksum:i770EB8E6B7F9D842
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28144 Genomic DNA. Translation: AAA86895.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28144 Genomic DNA. Translation: AAA86895.1 .

    3D structure databases

    ProteinModelPortali Q54699.
    SMRi Q54699. Positions 7-337.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi PL16. Polysaccharide Lyase Family 16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK Q54699.

    Family and domain databases

    InterProi IPR009860. Hyaluronidase_bac.
    [Graphical view ]
    Pfami PF07212. Hyaluronidase_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity."
      Hynes W.L., Hancock L., Ferretti J.J.
      Infect. Immun. 63:3015-3020(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHYLP2_BPH45
    AccessioniPrimary (citable) accession number: Q54699
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3