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Protein

Hyaluronoglucosaminidase

Gene

HYLP2

Organism
Streptococcus pyogenes phage H10403
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.36. 8503.
SABIO-RKQ54699.

Protein family/group databases

CAZyiPL16. Polysaccharide Lyase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronoglucosaminidase (EC:3.2.1.35)
Short name:
Hyaluronidase
Gene namesi
Name:HYLP2
OrganismiStreptococcus pyogenes phage H10403
Taxonomic identifieri86065 [NCBI]
Taxonomic lineageiVirusesunclassified phages
Virus hostiStreptococcus pyogenes [TaxID: 1314]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337HyaluronoglucosaminidasePRO_0000057724Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54699.
SMRiQ54699. Positions 7-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 69 family.Curated

Family and domain databases

InterProiIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamiPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS
60 70 80 90 100
DLGYISPLDY NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE
110 120 130 140 150
LDKKLNLKGG VMTGQLKFKP AATVAYSSST GGAVNIDLSS TRGAGVVVYS
160 170 180 190 200
DNDTSDGPLM SLRTGKETFN QSALFVDYKG TTNAVNIAMR HATTPNFSSA
210 220 230 240 250
LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK NAARYPLILS
260 270 280 290 300
KRQNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS
310 320 330
QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK
Length:337
Mass (Da):36,453
Last modified:October 31, 1996 - v1
Checksum:i770EB8E6B7F9D842
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28144 Genomic DNA. Translation: AAA86895.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28144 Genomic DNA. Translation: AAA86895.1.

3D structure databases

ProteinModelPortaliQ54699.
SMRiQ54699. Positions 7-337.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiPL16. Polysaccharide Lyase Family 16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.2.1.36. 8503.
SABIO-RKQ54699.

Family and domain databases

InterProiIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamiPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity."
    Hynes W.L., Hancock L., Ferretti J.J.
    Infect. Immun. 63:3015-3020(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHYLP2_BPH45
AccessioniPrimary (citable) accession number: Q54699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.