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Q54699

- HYLP2_BPH45

UniProt

Q54699 - HYLP2_BPH45

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Protein

Hyaluronoglucosaminidase

Gene
HYLP2
Organism
Streptococcus pyogenes phage H10403
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The hyaluronidase of this bacteriophage mediates the penetration of the hyaluronic capsule of Streptococcus pyogenes.

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKQ54699.

Protein family/group databases

CAZyiPL16. Polysaccharide Lyase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronoglucosaminidase (EC:3.2.1.35)
Short name:
Hyaluronidase
Gene namesi
Name:HYLP2
OrganismiStreptococcus pyogenes phage H10403
Taxonomic identifieri86065 [NCBI]
Taxonomic lineageiVirusesunclassified phages
Virus hostiStreptococcus pyogenes [TaxID: 1314]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337HyaluronoglucosaminidasePRO_0000057724Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54699.
SMRiQ54699. Positions 7-337.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009860. Hyaluronidase_bac.
[Graphical view]
PfamiPF07212. Hyaluronidase_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54699-1 [UniParc]FASTAAdd to Basket

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MSENIPLRVQ FKRMKAAEWA RSDVILLESE IGFETDTGFA RAGDGHNRFS    50
DLGYISPLDY NLLTNKPNID GLATKVETAQ KLQQKADKET VYTKAESKQE 100
LDKKLNLKGG VMTGQLKFKP AATVAYSSST GGAVNIDLSS TRGAGVVVYS 150
DNDTSDGPLM SLRTGKETFN QSALFVDYKG TTNAVNIAMR HATTPNFSSA 200
LNITSGNENG SAMQLRGSEK ALGTLKITHE NPSIGADYDK NAARYPLILS 250
KRQNGAGTAA QGIYINSTSG TTGKLLRIRN LSDDKFYVKS DGGFYAKETS 300
QIDGNLKLKD PTANDHAATK AYVDKAISEL KKLILKK 337
Length:337
Mass (Da):36,453
Last modified:November 1, 1996 - v1
Checksum:i770EB8E6B7F9D842
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28144 Genomic DNA. Translation: AAA86895.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28144 Genomic DNA. Translation: AAA86895.1 .

3D structure databases

ProteinModelPortali Q54699.
SMRi Q54699. Positions 7-337.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi PL16. Polysaccharide Lyase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK Q54699.

Family and domain databases

InterProi IPR009860. Hyaluronidase_bac.
[Graphical view ]
Pfami PF07212. Hyaluronidase_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity."
    Hynes W.L., Hancock L., Ferretti J.J.
    Infect. Immun. 63:3015-3020(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHYLP2_BPH45
AccessioniPrimary (citable) accession number: Q54699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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