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Protein

Eukaryotic translation initiation factor 6

Gene

Eif6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotation
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:Eif6Imported
Synonyms:EIF6UniRule annotation, ITGB4BPUniRule annotation, Itgb4bpImported
ORF Names:mCG_21067Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1196288. Eif6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei165PhosphothreonineUniRule annotation1
Modified residuei166PhosphoserineUniRule annotation1
Modified residuei174Phosphoserine; by CK1UniRule annotation1
Modified residuei175Phosphoserine; by CK1UniRule annotation1

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000027613.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
HOVERGENiHBG001300.
KOiK03264.
OMAiTAGNRHG.
OrthoDBiEOG091G0HYF.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiView protein in InterPro
IPR002769. eIF6.
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiView protein in Pfam
PF01912. eIF-6. 1 hit.
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiView protein in SMART
SM00654. eIF6. 1 hit.
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q545K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRASFENN CEVGCFAKLT NAYCLVAIGG SENFYSVFEG ELSDAIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD SVQIRRVEER
110 120 130 140 150
LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS
160 170 180 190 200
YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVVES VFKLNEAKPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,511
Last modified:May 24, 2005 - v1
Checksum:i35BF0F4C17D5E045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003447 mRNA. Translation: BAB22796.1.
AK007594 mRNA. Translation: BAB25125.1.
AK012218 mRNA. Translation: BAB28105.1.
AK088707 mRNA. Translation: BAC40517.1.
AK134364 mRNA. Translation: BAE22116.1.
AK150400 mRNA. Translation: BAE29526.1.
AK150720 mRNA. Translation: BAE29798.1.
AK151089 mRNA. Translation: BAE30102.1.
AK151102 mRNA. Translation: BAE30112.1.
AK151644 mRNA. Translation: BAE30574.1.
AK152093 mRNA. Translation: BAE30941.1.
AK159157 mRNA. Translation: BAE34862.1.
AK165946 mRNA. Translation: BAE38478.1.
AK167422 mRNA. Translation: BAE39510.1.
AK168257 mRNA. Translation: BAE40205.1.
CH466551 Genomic DNA. Translation: EDL06146.1.
RefSeqiNP_034709.1. NM_010579.2.
UniGeneiMm.271674.

Genome annotation databases

GeneIDi16418.
KEGGimmu:16418.

Similar proteinsi

Entry informationi

Entry nameiQ545K4_MOUSE
AccessioniPrimary (citable) accession number: Q545K4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)