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Protein
Submitted name:

Putative uncharacterized protein

Gene

Tgfa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Submitted name:
Transforming growth factor alphaImported
Submitted name:
Transforming growth factor alpha, isoform CRA_bImported
Gene namesi
Name:TgfaImported
ORF Names:mCG_130510Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98724. Tgfa.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei98 – 120HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500934342823 – 159Sequence analysisAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 81PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000029999.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032066.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 82EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IVW5. Eukaryota.
ENOG4111Z4I. LUCA.
HOVERGENiHBG000330.
KOiK08774.
OMAiLIHCCEV.
OrthoDBiEOG091G0RK4.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q545E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPATGQLAL LALGILLAVC QALENSTSPL SDSPVAAAVV SHFNKCPDSH
60 70 80 90 100
TQYCFHGTCR FLVQEEKPAC VCHSGYVGVR CEHADLLAVV AASQKKQAIT
110 120 130 140 150
ALVVVSIVAL AVLIITCVLI HCCQLRKHCE WCRALVCRHE KPSALLKGRT

ACCHSETVV
Length:159
Mass (Da):17,018
Last modified:May 24, 2005 - v1
Checksum:iBE0AE8D89CE7DDFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132185 mRNA. Translation: AAI32186.1.
BC132211 mRNA. Translation: AAI32212.1.
AK010785 mRNA. Translation: BAB27181.1.
AK162680 mRNA. Translation: BAE37019.1.
AK166321 mRNA. Translation: BAE38704.1.
CH466523 Genomic DNA. Translation: EDK99159.1.
RefSeqiNP_112476.1. NM_031199.4.
UniGeneiMm.137222.

Genome annotation databases

GeneIDi21802.
KEGGimmu:21802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132185 mRNA. Translation: AAI32186.1.
BC132211 mRNA. Translation: AAI32212.1.
AK010785 mRNA. Translation: BAB27181.1.
AK162680 mRNA. Translation: BAE37019.1.
AK166321 mRNA. Translation: BAE38704.1.
CH466523 Genomic DNA. Translation: EDK99159.1.
RefSeqiNP_112476.1. NM_031199.4.
UniGeneiMm.137222.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21802.
KEGGimmu:21802.

Organism-specific databases

CTDi7039.
MGIiMGI:98724. Tgfa.

Phylogenomic databases

eggNOGiENOG410IVW5. Eukaryota.
ENOG4111Z4I. LUCA.
HOVERGENiHBG000330.
KOiK08774.
OMAiLIHCCEV.
OrthoDBiEOG091G0RK4.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029999.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ545E4_MOUSE
AccessioniPrimary (citable) accession number: Q545E4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: February 15, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.