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Protein
Submitted name:

Transforming growth factor alpha

Gene

Tgfa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transforming growth factor alphaImported
Submitted name:
Transforming growth factor alpha, isoform CRA_bImported
Gene namesi
Name:TgfaImported
ORF Names:mCG_130510Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98724. Tgfa.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei98 – 120HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501084403523 – 159Sequence analysisAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 81PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiQ545E4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029999.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ545E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 82EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IVW5. Eukaryota.
ENOG4111Z4I. LUCA.
HOVERGENiHBG000330.
KOiK08774.
OMAiLIHCCEV.
OrthoDBiEOG091G0RK4.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q545E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPATGQLAL LALGILLAVC QALENSTSPL SDSPVAAAVV SHFNKCPDSH
60 70 80 90 100
TQYCFHGTCR FLVQEEKPAC VCHSGYVGVR CEHADLLAVV AASQKKQAIT
110 120 130 140 150
ALVVVSIVAL AVLIITCVLI HCCQLRKHCE WCRALVCRHE KPSALLKGRT

ACCHSETVV
Length:159
Mass (Da):17,018
Last modified:May 24, 2005 - v1
Checksum:iBE0AE8D89CE7DDFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132185 mRNA. Translation: AAI32186.1.
BC132211 mRNA. Translation: AAI32212.1.
AK010785 mRNA. Translation: BAB27181.1.
AK162680 mRNA. Translation: BAE37019.1.
AK166321 mRNA. Translation: BAE38704.1.
CH466523 Genomic DNA. Translation: EDK99159.1.
RefSeqiNP_112476.1. NM_031199.4.
UniGeneiMm.137222.

Genome annotation databases

GeneIDi21802.
KEGGimmu:21802.

Similar proteinsi

Entry informationi

Entry nameiQ545E4_MOUSE
AccessioniPrimary (citable) accession number: Q545E4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation