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Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus pneumoniae
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Pathwayi: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCapsule biogenesis/degradation, Exopolysaccharide synthesis
LigandManganese

Enzyme and pathway databases

UniPathwayiUPA00934

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Synonyms:cap1B, cps19fB
OrganismiStreptococcus pneumoniae
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi199D → N: Loss of activity; when associated with Q-201. 1 Publication1
Mutagenesisi201H → Q: Loss of activity; when associated with N-199. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578921 – 243Tyrosine-protein phosphatase CpsBAdd BLAST243

Structurei

3D structure databases

ProteinModelPortaliQ54518
SMRiQ54518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR016667 Caps_polysacc_synth_CpsB/CapC
IPR032466 Metal_Hydrolase
PANTHERiPTHR39181 PTHR39181, 1 hit
PIRSFiPIRSF016557 Caps_synth_CpsB, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit

Sequencei

Sequence statusi: Complete.

Q54518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDIHSHIVF DVDDGPKSRE ESKALLAESY RQGVRTIVST SHRRKGMFET
60 70 80 90 100
PEEKIAENFL QVREIAKEVA DDLVIAYGAE IYYTLDALEK LEKKEIPTLN
110 120 130 140 150
DSRYALIEFS MHTSYRQIHT GLSNILMLGI TPVIAHIERY DALENNEKRV
160 170 180 190 200
RELIDMGCYT QINSYHVSKP KFFGEKYKFM KKRARYFLER DLVHVVASDM
210 220 230 240
HNLDSRPPYM QQAYDIIAKK YGAKKAKELF VDNPRKIIMD QLI
Length:243
Mass (Da):28,354
Last modified:November 1, 1996 - v1
Checksum:i810A4C802EC43079
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti226A → V in strain: NCTC 11906. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09239 Genomic DNA Translation: AAC44959.1
Z83335 Genomic DNA Translation: CAB05935.1
AF030367 Genomic DNA Translation: AAC38717.1
AF030368 Genomic DNA Translation: AAC38722.1
AF030369 Genomic DNA Translation: AAC38727.1
AF030370 Genomic DNA Translation: AAC38731.1
AF030371 Genomic DNA Translation: AAC38736.1
AF030372 Genomic DNA Translation: AAC38741.1
AF106137 Genomic DNA Translation: AAD17985.1
RefSeqiWP_000565348.1, NZ_PIZF01000014.1
WP_000565349.1, NZ_FYMI01000027.1

Similar proteinsi

Entry informationi

Entry nameiCPSB_STREE
AccessioniPrimary (citable) accession number: Q54518
Secondary accession number(s): O08049, O08278, O52232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health