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Protein
Submitted name:

Mannosidase 1, alpha, isoform CRA_a

Gene

Man1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Names & Taxonomyi

Protein namesi
Submitted name:
Mannosidase 1, alpha, isoform CRA_aImported
Gene namesi
Name:Man1aImported
ORF Names:mCG_50876Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:104677. Man1a.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. endoplasmic reticulum-Golgi intermediate compartment Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. Golgi apparatus Source: MGI
  5. Golgi membrane Source: MGI
  6. membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ544T7.

Expressioni

Gene expression databases

BgeeiQ544T7.
ExpressionAtlasiQ544T7. baseline and differential.
GenevestigatoriQ544T7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101110.

Structurei

3D structure databases

ProteinModelPortaliQ544T7.
SMRiQ544T7. Positions 178-644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000016529.
HOVERGENiHBG052389.
KOiK01230.
OMAiAWEAVEX.
PhylomeDBiQ544T7.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

Q544T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVGGLLPLF SSPGGGGLGS GLGGGLGGGR KGSGPAAFRL TEKFVLLLVF
60 70 80 90 100
SAFITLCFGA IFFLPDSSKL LSGVLFHSNP ALQPPAEHKP GLGARAEDAA
110 120 130 140 150
EGRVRHREEG APGDPGAGLE DNLARIRENH ERALREAKET LQKLPEEIQR
160 170 180 190 200
DILLEKEKVA QDQLRDKDLF RGLPKVDFLP PVGVENREPA DATIREKRAK
210 220 230 240 250
IKEMMTHAWN NYKRYAWGLN ELKPISKEGH SSSLFGNIKG ATIVDALDTL
260 270 280 290 300
FIMGMKTEFQ EAKSWIKKYL DFNVNAEVSV FEVNIRFVGG LLSAYYLSGE
310 320 330 340 350
EIFRKKAVEL GVKLLPAFHT PSGIPWALLN MKSGIGRNWP WASGGSSILA
360 370 380 390 400
EFGTLHLEFM HLSHLSGDPV FAEKVMKIRT VLNKLDKPEG LYPNYLNPSS
410 420 430 440 450
GQWGQHHVSV GGLGDSFYEY LLKAWLMSDK TDLEAKKMYF DAVQAIETHL
460 470 480 490 500
IRKSSGGLTY IAEWKGGLLE HKMGHLTCFA GGMFALGADG APEARAQHYL
510 520 530 540 550
ELGAEIARTC HESYNRTYVK LGPEAFRFDG GVEAIATRQN EKYYILRPEV
560 570 580 590 600
IETYMYMWRL THDPKYRTWA WEAVEALESH CRVNGGYSGL RDVYIARESY
610 620 630 640 650
DDVQQSFFLA ETLKYLYLIF SDDDLLPLEH WIFNTEAHPF PILREQKKEI

DGKEK
Length:655
Mass (Da):73,276
Last modified:May 23, 2005 - v1
Checksum:i15AF658364930BF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031038 mRNA. Translation: BAC27225.1.
AK154820 mRNA. Translation: BAE32852.1.
CH466540 Genomic DNA. Translation: EDL05098.1.
CH466540 Genomic DNA. Translation: EDL05100.1.
RefSeqiNP_032574.1. NM_008548.4.
XP_006512632.1. XM_006512569.2.
UniGeneiMm.117294.

Genome annotation databases

GeneIDi17155.
KEGGimmu:17155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031038 mRNA. Translation: BAC27225.1.
AK154820 mRNA. Translation: BAE32852.1.
CH466540 Genomic DNA. Translation: EDL05098.1.
CH466540 Genomic DNA. Translation: EDL05100.1.
RefSeqiNP_032574.1. NM_008548.4.
XP_006512632.1. XM_006512569.2.
UniGeneiMm.117294.

3D structure databases

ProteinModelPortaliQ544T7.
SMRiQ544T7. Positions 178-644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101110.

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Proteomic databases

PRIDEiQ544T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17155.
KEGGimmu:17155.

Organism-specific databases

CTDi17155.
MGIiMGI:104677. Man1a.

Phylogenomic databases

GeneTreeiENSGT00390000016529.
HOVERGENiHBG052389.
KOiK01230.
OMAiAWEAVEX.
PhylomeDBiQ544T7.

Miscellaneous databases

ChiTaRSiMan1a. mouse.
NextBioi291418.
SOURCEiSearch...

Gene expression databases

BgeeiQ544T7.
ExpressionAtlasiQ544T7. baseline and differential.
GenevestigatoriQ544T7.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: NODImported.
  9. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and NODImported.
    Tissue: ThymusImported.
  11. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ544T7_MOUSE
AccessioniPrimary (citable) accession number: Q544T7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 23, 2005
Last sequence update: May 23, 2005
Last modified: March 31, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.