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Protein
Submitted name:

Melanocortin 2 receptor

Gene

Mc2r

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 2 receptorImported
Submitted name:
Melanocortin 2 receptor, isoform CRA_aImported
Gene namesi
Name:Mc2rImported
ORF Names:mCG_6051Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96928. Mc2r.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST
Transmembranei104 – 12623HelicalSequence analysisAdd
BLAST
Transmembranei147 – 16822HelicalSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Transmembranei221 – 24424HelicalSequence analysisAdd
BLAST
Transmembranei256 – 27823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000045569.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058691.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 276236G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG108148.
KOiK04200.
OMAiAVIWTFC.
OrthoDBiEOG091G0BVW.

Family and domain databases

InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q544P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHIINSYEH TNDTARNNSD CPDVVLPEEI FFTISVIGIL ENLIVLLAVI
60 70 80 90 100
KNKNLQSPMY FFICSLAISD MLGSLYKILE NILIMFRNMG YLKPRGSFES
110 120 130 140 150
TADDIIDCMF ILSLLGSIFS LSVIAADRYI TIFHALQYHS IVTMRRTIIT
160 170 180 190 200
LTIIWMFCTG SGITMVIFSH HIPTVLTFTS LFPLMLVFIL CLYIHMFLLA
210 220 230 240 250
RSHARKISTL PRTNMKGAMT LTILLGVFIF CWAPFVLHVL LMTFCPNNPY
260 270 280 290
CVCYMSLFQV NGMLIMCNAV IDPFIYAFRS PELRDAFKRM LFCNRY
Length:296
Mass (Da):33,982
Last modified:May 24, 2005 - v1
Checksum:i8ECB3D9A028CB9B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139210 mRNA. Translation: AAI39211.1.
BC139211 mRNA. Translation: AAI39212.1.
AK033100 mRNA. Translation: BAC28151.1.
CH466528 Genomic DNA. Translation: EDL09606.1.
CH466528 Genomic DNA. Translation: EDL09607.1.
CH466528 Genomic DNA. Translation: EDL09608.1.
CH466528 Genomic DNA. Translation: EDL09609.1.
RefSeqiNP_001258645.1. NM_001271716.1.
NP_001258646.1. NM_001271717.1.
NP_001288301.1. NM_001301372.1.
NP_032586.1. NM_008560.3.
UniGeneiMm.426053.

Genome annotation databases

GeneIDi17200.
KEGGimmu:17200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139210 mRNA. Translation: AAI39211.1.
BC139211 mRNA. Translation: AAI39212.1.
AK033100 mRNA. Translation: BAC28151.1.
CH466528 Genomic DNA. Translation: EDL09606.1.
CH466528 Genomic DNA. Translation: EDL09607.1.
CH466528 Genomic DNA. Translation: EDL09608.1.
CH466528 Genomic DNA. Translation: EDL09609.1.
RefSeqiNP_001258645.1. NM_001271716.1.
NP_001258646.1. NM_001271717.1.
NP_001288301.1. NM_001301372.1.
NP_032586.1. NM_008560.3.
UniGeneiMm.426053.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058691.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17200.
KEGGimmu:17200.

Organism-specific databases

CTDi4158.
MGIiMGI:96928. Mc2r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG108148.
KOiK04200.
OMAiAVIWTFC.
OrthoDBiEOG091G0BVW.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045569.

Family and domain databases

InterProiIPR001168. ACTH_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF3. PTHR22750:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00520. ACTROPHINR.
PR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ544P9_MOUSE
AccessioniPrimary (citable) accession number: Q544P9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.