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Protein
Submitted name:

Melanocortin 3 receptor

Gene

Mc3r

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 3 receptorImported
Gene namesi
Name:Mc3rImported
ORF Names:mCG_2575Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96929 Mc3r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei76 – 99HelicalSequence analysisAdd BLAST24
Transmembranei119 – 140HelicalSequence analysisAdd BLAST22
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei187 – 212HelicalSequence analysisAdd BLAST26
Transmembranei241 – 266HelicalSequence analysisAdd BLAST26
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000038537

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 299G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST245

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG108148
KOiK04201
OMAiVHMFLFA
OrthoDBiEOG091G0BVW

Family and domain databases

CDDicd15352 7tmA_MC3R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002122 Mcort_3_rcpt
IPR001908 Melancort_rcpt
IPR001671 Melcrt_ACTH_rcpt
PANTHERiPTHR22750:SF4 PTHR22750:SF4, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01061 MELNOCORTN3R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q544G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI
60 70 80 90 100
VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV
110 120 130 140 150
INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV
210 220 230 240 250
LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF KEILCGCNSM NLG
Length:323
Mass (Da):35,806
Last modified:May 24, 2005 - v1
Checksum:iF4B7B02FA4A87B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104730 mRNA Translation: AAI04731.1
BC105667 mRNA Translation: AAI05668.1
BC105668 mRNA Translation: AAI05669.1
AK038677 mRNA Translation: BAC30094.1
CH466551 Genomic DNA Translation: EDL06595.1
RefSeqiNP_032587.1, NM_008561.3
UniGeneiMm.57183

Genome annotation databases

GeneIDi17201
KEGGimmu:17201

Similar proteinsi

Entry informationi

Entry nameiQ544G7_MOUSE
AccessioniPrimary (citable) accession number: Q544G7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)