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Protein
Submitted name:

Melanocortin 3 receptor

Gene

Mc3r

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 3 receptorImported
Gene namesi
Name:Mc3rImported
ORF Names:mCG_2575Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96929. Mc3r.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9924HelicalSequence analysisAdd
BLAST
Transmembranei119 – 14022HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Transmembranei187 – 21226HelicalSequence analysisAdd
BLAST
Transmembranei241 – 26626HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000038537.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047358.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 299245G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOVERGENiHBG108148.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG091G0BVW.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q544G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSCCLSSV SPMLPNLSEH PAAPPASNRS GSGFCEQVFI KPEVFLALGI
60 70 80 90 100
VSLMENILVI LAVVRNGNLH SPMYFFLCSL AAADMLVSLS NSLETIMIAV
110 120 130 140 150
INSDSLTLED QFIQHMDNIF DSMICISLVA SICNLLAIAI DRYVTIFYAL
160 170 180 190 200
RYHSIMTVRK ALTLIGVIWV CCGICGVMFI IYSESKMVIV CLITMFFAMV
210 220 230 240 250
LLMGTLYIHM FLFARLHVQR IAVLPPAGVV APQQHSCMKG AVTITILLGV
260 270 280 290 300
FIFCWAPFFL HLVLIITCPT NPYCICYTAH FNTYLVLIMC NSVIDPLIYA
310 320
FRSLELRNTF KEILCGCNSM NLG
Length:323
Mass (Da):35,806
Last modified:May 24, 2005 - v1
Checksum:iF4B7B02FA4A87B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104730 mRNA. Translation: AAI04731.1.
BC105667 mRNA. Translation: AAI05668.1.
BC105668 mRNA. Translation: AAI05669.1.
AK038677 mRNA. Translation: BAC30094.1.
CH466551 Genomic DNA. Translation: EDL06595.1.
RefSeqiNP_032587.1. NM_008561.3.
UniGeneiMm.57183.

Genome annotation databases

GeneIDi17201.
KEGGimmu:17201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104730 mRNA. Translation: AAI04731.1.
BC105667 mRNA. Translation: AAI05668.1.
BC105668 mRNA. Translation: AAI05669.1.
AK038677 mRNA. Translation: BAC30094.1.
CH466551 Genomic DNA. Translation: EDL06595.1.
RefSeqiNP_032587.1. NM_008561.3.
UniGeneiMm.57183.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047358.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17201.
KEGGimmu:17201.

Organism-specific databases

CTDi4159.
MGIiMGI:96929. Mc3r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00770000120529.
HOVERGENiHBG108148.
KOiK04201.
OMAiVHMFLFA.
OrthoDBiEOG091G0BVW.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038537.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002122. Mcort_3_rcpt.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF4. PTHR22750:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01061. MELNOCORTN3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ544G7_MOUSE
AccessioniPrimary (citable) accession number: Q544G7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.