Carbapenem-hydrolyzing beta-lactamase - Serratia marcescens

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Unreviewed, UniProtKB/TrEMBL Q54488 (Q54488_SERMA)

Last modified November 3, 2009. Version 42. History...

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Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Carbapenem-hydrolyzing beta-lactamase EMBL AAB03414.1

Gene names

Name:

sme-2 EMBL AAB03414.1

Organism

Serratia marcescens EMBL AAB03414.1

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Molecular function	Hydrolase Spearmint SPM001466
Gene Ontology (GO)
Biological process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: InterPro
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q54488-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C326C0DC65293094
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294

32,247

        10         20         30         40         50         60 
MSNKVNFKTA SFLFSVCLAL SAFNAHANKS DAAAKQIKKL EEDFDGRIGV FAIDTGSGNT 

        70         80         90        100        110        120 
FGYRSDERFP LCSSFKGFLA AAVLERVQQK KLDINQKVKY ESRDLEYHSP ITTKYKGSGM 

       130        140        150        160        170        180 
TLGDMASAAL QYSDNGATNI IMERFLGGPE GMTKFMRSIG DNEFRLDRWE LELNTAIPGD 

       190        200        210        220        230        240 
KRDTSTPKAV ANSLNKLALG NVLNAKVKAI YQNWLKGNTT GDARIRASVP ADWVVGDKTG 

       250        260        270        280        290 
SCGAYGTAND YAVIWPKNRA PLIVSIYTTR KSKDDKHSDK TIAEASRIAI QAID

References

[1]	"Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6." Naas T., Vandel L., Sougakoff W., Livermore D.M., Nordmann P. Antimicrob. Agents Chemother. 38:1262-1270(1994) [PubMed: 8092824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: S6 EMBL AAB03414.1.
[2]	"Carbapenem-hydrolyzing beta-lactamase, Sme-2." Rasmussen B.A., Keeney D., Cohen C. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S6 EMBL AAB03414.1.
[3]	"Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescens." Sougakoff W., L'Hermite G., Pernot L., Naas T., Guillet V., Nordmann P., Jarlier V., Delettre J. Acta Crystallogr. D Biol. Crystallogr. 58:267-274(2002) [PubMed: 11807251] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 28-294.
+	Additional computationally mapped references.

Cross-references

Sequence databases

U60295 Genomic DNA. Translation: AAB03414.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DY6	X-ray	2.13	A/B	28-294	[»]

ModBase

Family and domain databases

InterPro

IPR012338. B-lactamase-typ_transpept_fold.
IPR001466. Beta_lactamase-related.
IPR000871. Beta_lactamase_A/D.
[Graphical view]

Pfam

PF00144. Beta-lactamase. 1 hit.
[Graphical view]

PRINTS

PR00118. BLACTAMASEA.

ProtoNet

Entry information

Entry name

Q54488_SERMA

Accession

Primary (citable) accession number: Q54488

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information