Q54488 (Q54488_SERMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Carbapenem-hydrolyzing beta-lactamase EMBL AAB03414.1

Submitted name:
Serine carbapenemase EMBL AEJ79644.1

Gene names

Name:	sme-2 EMBL AAB03414.1
Synonyms:	blaSME1 EMBL AEJ79644.1

Organism

Serratia marcescens EMBL AAB03414.1

Taxonomic identifier

615 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid. SAAS SAAS012338

Ontologies

Keywords
Biological process	Antibiotic resistance SAAS SAAS012338
Molecular function	Hydrolase SAAS SAAS012338
Technical term	3D-structure PDB 1DY6
Gene Ontology (GO)
Biological process	beta-lactam antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	beta-lactamase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q54488 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C326C0DC65293094	FASTA	294	32,247
	10 20 30 40 50 60 MSNKVNFKTA SFLFSVCLAL SAFNAHANKS DAAAKQIKKL EEDFDGRIGV FAIDTGSGNT 70 80 90 100 110 120 FGYRSDERFP LCSSFKGFLA AAVLERVQQK KLDINQKVKY ESRDLEYHSP ITTKYKGSGM 130 140 150 160 170 180 TLGDMASAAL QYSDNGATNI IMERFLGGPE GMTKFMRSIG DNEFRLDRWE LELNTAIPGD 190 200 210 220 230 240 KRDTSTPKAV ANSLNKLALG NVLNAKVKAI YQNWLKGNTT GDARIRASVP ADWVVGDKTG 250 260 270 280 290 SCGAYGTAND YAVIWPKNRA PLIVSIYTTR KSKDDKHSDK TIAEASRIAI QAID

References

[1]	"Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6." Naas T., Vandel L., Sougakoff W., Livermore D.M., Nordmann P. Antimicrob. Agents Chemother. 38:1262-1270(1994) [PubMed: 8092824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: S6 EMBL AAB03414.1.
[2]	"Detection of 2 SME-1 carbapenemase-producing Serratia marcescens in Detroit." Fairfax M.R., Queenan A.M., Lephart P.R., Kaye K.S., Dror M., Arnous N., Salimnia T.T., Mitchell R.A., Alangaden G., Salimnia H. Diagn. Microbiol. Infect. Dis. 71:325-326(2011) [PubMed: 21840669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SMDET-2 EMBL AEJ79644.1.
[3]	"Structure of the imipenem-hydrolyzing class A beta-lactamase SME-1 from Serratia marcescens." Sougakoff W., L'Hermite G., Pernot L., Naas T., Guillet V., Nordmann P., Jarlier V., Delettre J. Acta Crystallogr. D Biol. Crystallogr. 58:267-274(2002) [PubMed: 11807251] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.13 ANGSTROMS) OF 28-294.
[4]	Fairfax M., Queenan A.M., Lephart P., Kaye K., Dror M., Arnous N., Salimnia T., Mitchell R., Alangaden G., Salimnia H. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SMDET-2 EMBL AEJ79644.1.
[5]	"Carbapenem-hydrolyzing beta-lactamase, Sme-2." Rasmussen B.A., Keeney D., Cohen C. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: S6 EMBL AAB03414.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U60295 Genomic DNA. Translation: AAB03414.1.
JF974075 Genomic DNA. Translation: AEJ79644.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DY6	X-ray	2.13	A/B	28-294	[»]

ProteinModelPortal

Q54488.

SMR

Q54488. Positions 28-294.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view]

Gene3D

G3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.

Pfam

PF00144. Beta-lactamase. 1 hit.
[Graphical view]

PRINTS

PR00118. BLACTAMASEA.

SUPFAM

SSF56601. PBP_transp_fold. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q54488_SERMA

Accession

Primary (citable) accession number: Q54488

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)