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Protein

Probable phosphopantothenoylcysteine decarboxylase

Gene

coaC

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of 4'-phosphopantothenoylcysteine to 4'-phosphopantetheine.

Catalytic activityi

N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.

Cofactori

FMNBy similarityNote: Binds 1 FMN per subunit.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. no protein annotated in this organism
  3. Probable phosphopantothenoylcysteine decarboxylase (coaC)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124SubstrateBy similarity1
Active sitei157Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandFlavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphopantothenoylcysteine decarboxylase (EC:4.1.1.36)
Short name:
PPCDC
Gene namesi
Name:coaC
Ordered Locus Names:SMU_1075
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001820291 – 179Probable phosphopantothenoylcysteine decarboxylaseAdd BLAST179

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1075.

Structurei

3D structure databases

ProteinModelPortaliQ54433.
SMRiQ54433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
KOiK01598.
OMAiKHFYSPQ.
PhylomeDBiQ54433.

Family and domain databases

Gene3Di3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR011847. CoaC_strep.
IPR036551. Flavin_trans-like.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR02113. coaC_strep. 1 hit.

Sequencei

Sequence statusi: Complete.

Q54433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKILLAVS GSIAAYKAAD LSHQLTKLGY HVNVLMTNAA KQFIPPLTLQ
60 70 80 90 100
VLSKNPVYSN VMKEDDPQVI NHIALAKQAD LFLLAPASAN TLAHLAHGFA
110 120 130 140 150
DNIVTSVALA LPLEVPKFFA PAMNTKMYEN PITQSNIALL KKFGYKEIQP
160 170
KSSVLACGDV GSGALADLDT IIQKIEEQL
Length:179
Mass (Da):19,282
Last modified:November 28, 2002 - v2
Checksum:i3DB29C34CAA399CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → F in AAC44502 (PubMed:8763945).Curated1
Sequence conflicti85A → P in AAC44502 (PubMed:8763945).Curated1
Sequence conflicti138A → T in AAC44502 (PubMed:8763945).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58773.1.
U48885 Genomic DNA. Translation: AAC44502.1.
RefSeqiNP_721467.1. NC_004350.2.
WP_002262265.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58773; AAN58773; SMU_1075.
GeneIDi1028402.
KEGGismu:SMU_1075.
PATRICifig|210007.7.peg.962.

Similar proteinsi

Entry informationi

Entry nameiCOAC_STRMU
AccessioniPrimary (citable) accession number: Q54433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: October 25, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families