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Q54410

- TAP_STRLI

UniProt

Q54410 - TAP_STRLI

Protein

Tripeptidyl aminopeptidase

Gene

tap

Organism
Streptomyces lividans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cleaves tripeptides from the N-termini of proteins. Does not cleave mono- or dipeptides, or N-terminally blocked peptides.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei245 – 2451NucleophileBy similarity
    Active sitei470 – 4701By similarity
    Active sitei499 – 4991Proton donorBy similarity

    GO - Molecular functioni

    1. tripeptide aminopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS33.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripeptidyl aminopeptidase1 Publication (EC:3.4.14.-)
    Short name:
    Tap1 Publication
    Gene namesi
    Name:tap1 Publication
    OrganismiStreptomyces lividans
    Taxonomic identifieri1916 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Sequence AnalysisAdd
    BLAST
    Propeptidei37 – 3931 PublicationSequence AnalysisPRO_0000401063
    Chaini40 – 537498Tripeptidyl aminopeptidase1 PublicationPRO_5000142441Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ54410.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi10 – 7465Ala-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S33 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1820. 3 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR013595. Pept_S33_TAP-like_C.
    [Graphical view]
    PfamiPF08386. Abhydrolase_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q54410-1 [UniParc]FASTAAdd to Basket

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    MRKSSIRRRA TAFGTAGALV TATLIAGAVS APAASAAPAD GHGHGRSWDR    50
    EARGAAIAAA RAARAGIDWE DCAADWNLPK PIQCGYVTVP MDYAKPYGKQ 100
    IRLAVDRIGN TGTRSERQGA LIYNPGGPGG SGLRFPARVT NKSAVWANTA 150
    KAYDFVGFDP RGVGHSAPIS CVDPQEFVKA PKADPVPGSE ADKRAQRKLA 200
    REYAEGCFER SGEMLPHMTT PNTARDLDVI RAALGEKKLN YLGVSYGTYL 250
    GAVYGTLFPD HVRRMVVDSV VNPSRDKIWY QANLDQDVAF EGRWKDWQDW 300
    VAANDAAYHL GDTRAEVQDQ WLKLRAAAAK KPLGGVVGPA ELISFFQSAP 350
    YYDSAWAPTA EIFSKYVAGD TQALVDAAAP DLSDTAGNAS AENGNAVYTA 400
    VECTDAKWPA NWRTWDRDNT RLHRDHPFMT WANAWMNLPC ATWPVKQQTP 450
    LNVKTGKGLP PVLIVQSERD AATPYEGAVE LHQRFRGSRL ITERDAGSHG 500
    VTGLVNPCIN DRVDTYLLTG RTDARDVTCA PHATPRP 537
    Length:537
    Mass (Da):58,273
    Last modified:November 1, 1996 - v1
    Checksum:i850703374BC4DEC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27466 Genomic DNA. Translation: AAA92338.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27466 Genomic DNA. Translation: AAA92338.1 .

    3D structure databases

    ProteinModelPortali Q54410.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S33.002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 3 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR013595. Pept_S33_TAP-like_C.
    [Graphical view ]
    Pfami PF08386. Abhydrolase_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66."
      Butler M.J., Binnie C., DiZonno M.A., Krygsman P., Soltes G.A., Soostmeyer G., Walczyk E., Malek L.T.
      Appl. Environ. Microbiol. 61:3145-3150(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 40-50, FUNCTION, SUBCELLULAR LOCATION.
      Strain: 66 / 13261 Publication.

    Entry informationi

    Entry nameiTAP_STRLI
    AccessioniPrimary (citable) accession number: Q54410
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3