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Q54410 (TAP_STRLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripeptidyl aminopeptidase

Short name=Tap
EC=3.4.14.-
Gene names
Name:tap
OrganismStreptomyces lividans
Taxonomic identifier1916 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cleaves tripeptides from the N-termini of proteins. Does not cleave mono- or dipeptides, or N-terminally blocked peptides. Ref.1

Subcellular location

Secreted Ref.1.

Sequence similarities

Belongs to the peptidase S33 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAminopeptidase
Hydrolase
Protease
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from direct assay Ref.1. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functiontripeptide aminopeptidase activity

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Potential
Propeptide37 – 393 Ref.1
PRO_0000401063
Chain40 – 537498Tripeptidyl aminopeptidase Ref.1
PRO_5000142441

Regions

Compositional bias10 – 7465Ala-rich

Sites

Active site2451Nucleophile By similarity
Active site4701 By similarity
Active site4991Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q54410 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 850703374BC4DEC9

FASTA53758,273
        10         20         30         40         50         60 
MRKSSIRRRA TAFGTAGALV TATLIAGAVS APAASAAPAD GHGHGRSWDR EARGAAIAAA 

        70         80         90        100        110        120 
RAARAGIDWE DCAADWNLPK PIQCGYVTVP MDYAKPYGKQ IRLAVDRIGN TGTRSERQGA 

       130        140        150        160        170        180 
LIYNPGGPGG SGLRFPARVT NKSAVWANTA KAYDFVGFDP RGVGHSAPIS CVDPQEFVKA 

       190        200        210        220        230        240 
PKADPVPGSE ADKRAQRKLA REYAEGCFER SGEMLPHMTT PNTARDLDVI RAALGEKKLN 

       250        260        270        280        290        300 
YLGVSYGTYL GAVYGTLFPD HVRRMVVDSV VNPSRDKIWY QANLDQDVAF EGRWKDWQDW 

       310        320        330        340        350        360 
VAANDAAYHL GDTRAEVQDQ WLKLRAAAAK KPLGGVVGPA ELISFFQSAP YYDSAWAPTA 

       370        380        390        400        410        420 
EIFSKYVAGD TQALVDAAAP DLSDTAGNAS AENGNAVYTA VECTDAKWPA NWRTWDRDNT 

       430        440        450        460        470        480 
RLHRDHPFMT WANAWMNLPC ATWPVKQQTP LNVKTGKGLP PVLIVQSERD AATPYEGAVE 

       490        500        510        520        530 
LHQRFRGSRL ITERDAGSHG VTGLVNPCIN DRVDTYLLTG RTDARDVTCA PHATPRP 

« Hide

References

[1]"Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66."
Butler M.J., Binnie C., DiZonno M.A., Krygsman P., Soltes G.A., Soostmeyer G., Walczyk E., Malek L.T.
Appl. Environ. Microbiol. 61:3145-3150(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 40-50, FUNCTION, SUBCELLULAR LOCATION.
Strain: 66 / 1326.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27466 Genomic DNA. Translation: AAA92338.1.

3D structure databases

ProteinModelPortalQ54410.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS33.002.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR013595. Pept_S33_TAP-like_C.
[Graphical view]
PfamPF08386. Abhydrolase_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTAP_STRLI
AccessionPrimary (citable) accession number: Q54410
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries