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Q54410

- TAP_STRLI

UniProt

Q54410 - TAP_STRLI

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Protein

Tripeptidyl aminopeptidase

Gene

tap

Organism
Streptomyces lividans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cleaves tripeptides from the N-termini of proteins. Does not cleave mono- or dipeptides, or N-terminally blocked peptides.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei245 – 2451NucleophileBy similarity
Active sitei470 – 4701By similarity
Active sitei499 – 4991Proton donorBy similarity

GO - Molecular functioni

  1. tripeptide aminopeptidase activity Source: UniProtKB

GO - Biological processi

  1. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS33.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripeptidyl aminopeptidase1 Publication (EC:3.4.14.-)
Short name:
Tap1 Publication
Gene namesi
Name:tap1 Publication
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Propeptidei37 – 3931 PublicationSequence AnalysisPRO_0000401063
Chaini40 – 537498Tripeptidyl aminopeptidase1 PublicationPRO_5000142441Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 7465Ala-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
InterProiIPR029058. AB_hydrolase.
IPR013595. Pept_S33_TAP-like_C.
[Graphical view]
PfamiPF08386. Abhydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q54410-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKSSIRRRA TAFGTAGALV TATLIAGAVS APAASAAPAD GHGHGRSWDR
60 70 80 90 100
EARGAAIAAA RAARAGIDWE DCAADWNLPK PIQCGYVTVP MDYAKPYGKQ
110 120 130 140 150
IRLAVDRIGN TGTRSERQGA LIYNPGGPGG SGLRFPARVT NKSAVWANTA
160 170 180 190 200
KAYDFVGFDP RGVGHSAPIS CVDPQEFVKA PKADPVPGSE ADKRAQRKLA
210 220 230 240 250
REYAEGCFER SGEMLPHMTT PNTARDLDVI RAALGEKKLN YLGVSYGTYL
260 270 280 290 300
GAVYGTLFPD HVRRMVVDSV VNPSRDKIWY QANLDQDVAF EGRWKDWQDW
310 320 330 340 350
VAANDAAYHL GDTRAEVQDQ WLKLRAAAAK KPLGGVVGPA ELISFFQSAP
360 370 380 390 400
YYDSAWAPTA EIFSKYVAGD TQALVDAAAP DLSDTAGNAS AENGNAVYTA
410 420 430 440 450
VECTDAKWPA NWRTWDRDNT RLHRDHPFMT WANAWMNLPC ATWPVKQQTP
460 470 480 490 500
LNVKTGKGLP PVLIVQSERD AATPYEGAVE LHQRFRGSRL ITERDAGSHG
510 520 530
VTGLVNPCIN DRVDTYLLTG RTDARDVTCA PHATPRP
Length:537
Mass (Da):58,273
Last modified:November 1, 1996 - v1
Checksum:i850703374BC4DEC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27466 Genomic DNA. Translation: AAA92338.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27466 Genomic DNA. Translation: AAA92338.1 .

3D structure databases

ProteinModelPortali Q54410.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S33.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 3 hits.
InterProi IPR029058. AB_hydrolase.
IPR013595. Pept_S33_TAP-like_C.
[Graphical view ]
Pfami PF08386. Abhydrolase_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66."
    Butler M.J., Binnie C., DiZonno M.A., Krygsman P., Soltes G.A., Soostmeyer G., Walczyk E., Malek L.T.
    Appl. Environ. Microbiol. 61:3145-3150(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 40-50, FUNCTION, SUBCELLULAR LOCATION.
    Strain: 66 / 13261 Publication.

Entry informationi

Entry nameiTAP_STRLI
AccessioniPrimary (citable) accession number: Q54410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3