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Unreviewed, UniProtKB/TrEMBL Q543V3 (Q543V3_MOUSE)

Last modified February 9, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAC32308.1
Submitted name:
    Insulin receptor substrate 1 EMBL EDL02131.1
Gene names
Name: Irs1 MGI 99454
ORF Names: mCG_20326 EMBL EDL02131.1
OrganismMus musculus (Mouse) EMBL BAC32308.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1231 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 PH domain.

Ontologies

Keywords
   Molecular functionReceptor EMBL EDL02131.1
Gene Ontology (GO)
   Biological processinsulin-like growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Compara

mammary gland development

Inferred from genetic interaction. Source: MGI

negative regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Compara

phosphoinositide 3-kinase cascade

Inferred from electronic annotation. Source: Compara

positive regulation of cell migration

Inferred from genetic interaction. Source: MGI

positive regulation of fatty acid beta-oxidation

Inferred from electronic annotation. Source: Compara

positive regulation of glucose import

Inferred from electronic annotation. Source: Compara

positive regulation of glucose metabolic process

Inferred from electronic annotation. Source: Compara

positive regulation of glycogen biosynthetic process

Inferred from electronic annotation. Source: Compara

positive regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Compara

positive regulation of mesenchymal cell proliferation

Inferred from genetic interaction. Source: MGI

positive regulation of phosphoinositide 3-kinase activity

Inferred from electronic annotation. Source: Compara

protein heterooligomerization

Inferred from electronic annotation. Source: Compara

protein kinase B signaling cascade

Inferred from genetic interaction. Source: MGI

response to peptide hormone stimulus

Inferred from electronic annotation. Source: Compara

   Cellular componentcaveola

Inferred from electronic annotation. Source: Compara

cytoplasm

Inferred from direct assay. Source: MGI

insulin receptor complex

Inferred from electronic annotation. Source: Compara

microsome

Inferred from direct assay. Source: MGI

nucleus

Inferred from direct assay. Source: MGI

   Molecular functionSH2 domain binding

Inferred from electronic annotation. Source: Compara

insulin receptor binding

Inferred from electronic annotation. Source: Compara

insulin-like growth factor receptor activity

Inferred from electronic annotation. Source: Compara

insulin-like growth factor receptor binding

Inferred from electronic annotation. Source: Compara

phosphoinositide 3-kinase binding

Inferred from electronic annotation. Source: Compara

protein kinase C binding

Inferred from electronic annotation. Source: Compara

transmembrane receptor protein tyrosine kinase docking protein activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q543V3-1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FC4388974D9B561A

FASTA1,231130,584
        10         20         30         40         50         60 
MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP 

        70         80         90        100        110        120 
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKAH 

       130        140        150        160        170        180 
HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL 

       190        200        210        220        230        240 
CLTSKTISFV KLNSEAAAVV LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV 

       250        260        270        280        290        300 
AQNMHETILE AMRAMSDEFR PRSKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT 

       310        320        330        340        350        360 
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH AHRHRGSSRL 

       370        380        390        400        410        420 
HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD CLFPRRSSAS VSGSPSDGGF 

       430        440        450        460        470        480 
ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP ARGEEELSNY ICMGGKGAST LAAPNGHYIL 

       490        500        510        520        530        540 
SRGGNGHRYI PGANLGTSPA LPGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV 

       550        560        570        580        590        600 
ASIEEYTEMM PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDTS 

       610        620        630        640        650        660 
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP QRVDPNGYMM 

       670        680        690        700        710        720 
MSPSGSCSPD IGGGSSSSSS ISAAPSGSSY GKPWTNGVGG HHTHALPHAK PPVESGGGKL 

       730        740        750        760        770        780 
LPCTGDYMNM SPVGDSNTSS PSECYYGPED PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR 

       790        800        810        820        830        840 
HQHLRLSSSS GRLRYTATAE DSSSSTSSDS LGGGYCGARP ESSLTHPHHH VLQPHLPRKV 

       850        860        870        880        890        900 
DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQSSL HPPEPKSPGE YVNIEFGSGQ 

       910        920        930        940        950        960 
PGYLAGPATS RSSPSVRCPP QLHPAPREET GSEEYMNMDL GPGRRATWQE SGGVELGRIG 

       970        980        990       1000       1010       1020 
PAPPGSATVC RPTRSVPNSR GDYMTMQIGC PRQSYVDTSP VAPVSYADMR TGIAAEKASL 

      1030       1040       1050       1060       1070       1080 
PRPTGAAPPP SSTASSSVTP QGATAEQATH SSLLGGPQGP GGMSAFTRVN LSPNHNQSAK 

      1090       1100       1110       1120       1130       1140 
VIRADTQGCR RRHSSETFSA PTRAGNTVPF GAGAAVGGSG GGGGGGSEDV KRHSSASFEN 

      1150       1160       1170       1180       1190       1200 
VWLRPGDLGG VSKESAPVCG AAGGLEKSLN YIDLDLAKER SQDCPSQQQS LPPPPPHQPL 

      1210       1220       1230 
GSNEGNSPRR SSEDLSNYAS ISFQKQPEDR Q 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAC32308.1.
Tissue: Parthenogenote EMBL BAC32308.1 and Heart EMBL BAE24991.1.
[2]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed: 12040188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL02131.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL02131.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK045317 mRNA. Translation: BAC32308.1.
AK142242 mRNA. Translation: BAE24991.1.
CH466629 Genomic DNA. Translation: EDL02131.1.
IPIIPI00605223.
RefSeqNP_034700.2.
UniGeneMm.476433
Mm.4952

3D structure databases

SMRQ543V3. Positions 11-259, 152-262, 433-461.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ543V3.

Proteomic databases

PRIDEQ543V3.

Genome annotation databases

EnsemblENSMUST00000069799; ENSMUSP00000063795; ENSMUSG00000055980; Mus musculus. [Genome view]
GeneID16367.
KEGGmmu:16367.
UCSCuc007brp.1. mouse.

Organism-specific databases

CTD16367.
MGIMGI:99454. Irs1.

Phylogenomic databases

HOVERGENQ543V3.
InParanoidQ543V3.
OMAGCRRRHS.
OrthoDBEOG9BVVDQ.
PhylomeDBQ543V3.

Gene expression databases

ArrayExpressQ543V3.
BgeeQ543V3.
GenevestigatorQ543V3.

Family and domain databases

InterProIPR002404. Insln_rcpt_S1.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 2 hits.
PfamPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00628. INSULINRSI.
SMARTSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio289484.
SOURCESearch...

Entry information

Entry nameQ543V3_MOUSE
AccessionPrimary (citable) accession number: Q543V3
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information