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Protein
Submitted name:

Prostaglandin-endoperoxide synthase 1

Gene

Ptgs1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin-endoperoxide synthase 1Imported
Submitted name:
Ptgs1 proteinImported
Gene namesi
Name:Ptgs1Imported
ORF Names:mCG_22272Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97797. Ptgs1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501109938228 – 602Sequence analysisAdd BLAST575

Expressioni

Gene expression databases

BgeeiENSMUSG00000047250.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 72EGF-likeInterPro annotationAdd BLAST39

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2408. Eukaryota.
ENOG410XPZ3. LUCA.
HOVERGENiHBG000366.
KOiK00509.
OMAiFKTSGKM.
OrthoDBiEOG091G03CD.

Family and domain databases

InterProiView protein in InterPro
IPR029580. COX-1.
IPR000742. EGF-like_dom.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
PANTHERiPTHR11903:SF6. PTHR11903:SF6. 1 hit.
PfamiView protein in Pfam
PF03098. An_peroxidase. 1 hit.
PRINTSiPR00457. ANPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiView protein in PROSITE
PS50026. EGF_3. 1 hit.
PS50292. PEROXIDASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q543T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRSLSLWF PLLLLLLLPP TPSVLLADPG VPSPVNPCCY YPCQNQGVCV
60 70 80 90 100
RFGLDNYQCD CTRTGYSGPN CTIPEIWTWL RNSLRPSPSF THFLLTHGYW
110 120 130 140 150
LWEFVNATFI REVLMRLVLT VRSNLIPSPP TYNSAHDYIS WESFSNVSYY
160 170 180 190 200
TRILPSVPKD CPTPMGTKGK KQLPDVQLLA QQLLLRREFI PAPQGTNILF
210 220 230 240 250
AFFAQHFTHQ FFKTSGKMGP GFTKALGHGV DLGHIYGDNL ERQYHLRLFK
260 270 280 290 300
DGKLKYQVLD GEVYPPSVEQ ASVLMRYPPG VPPERQMAVG QEVFGLLPGL
310 320 330 340 350
MLFSTIWLRE HNRVCDLLKE EHPTWDDEQL FQTTRLILIG ETIKIVIEEY
360 370 380 390 400
VQHLSGYFLQ LKFDPELLFR AQFQYRNRIA MEFNHLYHWH PLMPNSFQVG
410 420 430 440 450
SQEYSYEQFL FNTSMLVDYG VEALVDAFSR QRAGRIGGGR NFDYHVLHVA
460 470 480 490 500
VDVIKESREM RLQPFNEYRK RFGLKPYTSF QELTGEKEMA AELEELYGDI
510 520 530 540 550
DALEFYPGLL LEKCQPNSIF GESMIEMGAP FSLKGLLGNP ICSPEYWKPS
560 570 580 590 600
TFGGDVGFNL VNTASLKKLV CLNTKTCPYV SFRVPDYPGD DGSVLVRRST

EL
Length:602
Mass (Da):69,042
Last modified:May 24, 2005 - v1
Checksum:i634C0E602045C3A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023322 mRNA. Translation: AAH23322.2.
AH015269
, DQ173708, DQ173710, DQ173711, DQ173712, DQ173713, DQ173714 Genomic DNA. Translation: ABA19088.1.
AH015270
, DQ173699, DQ173700, DQ173701, DQ173702, DQ173703, DQ173704 Genomic DNA. Translation: ABA19089.1.
AK046457 mRNA. Translation: BAC32737.1.
AK138432 mRNA. Translation: BAE23660.1.
AK142741 mRNA. Translation: BAE25179.1.
AK159907 mRNA. Translation: BAE35471.1.
AK163609 mRNA. Translation: BAE37419.1.
AK170414 mRNA. Translation: BAE41780.1.
AK170664 mRNA. Translation: BAE41945.1.
CT010314 mRNA. Translation: CAJ18522.1.
CH466542 Genomic DNA. Translation: EDL08676.1.
RefSeqiNP_032995.1. NM_008969.4.
XP_006497853.1. XM_006497790.3.
XP_006497854.1. XM_006497791.3.
XP_011237338.1. XM_011239036.2.
XP_017171985.1. XM_017316496.1.
UniGeneiMm.275434.

Genome annotation databases

GeneIDi19224.
KEGGimmu:19224.

Similar proteinsi

Entry informationi

Entry nameiQ543T1_MOUSE
AccessioniPrimary (citable) accession number: Q543T1
Secondary accession number(s): Q8CIL6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation