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Protein
Submitted name:

Chemokine (C-C motif) receptor 2

Gene

Ccr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-C motif) receptor 2Imported
Gene namesi
Name:Ccr2Imported
ORF Names:mCG_16379Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106185. Ccr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 8121HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11220HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15423HelicalSequence analysisAdd
BLAST
Transmembranei166 – 19126HelicalSequence analysisAdd
BLAST
Transmembranei221 – 24323HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27824HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000049103.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 318247G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
KOiK04177.
OMAiCPVFYRE.
OrthoDBiEOG091G0B7A.

Family and domain databases

InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q543S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDNNMLPQF IHGILSTSHS LFTRSIQELD EGATTPYDYD DGEPCHKTSV
60 70 80 90 100
KQIGAWILPP LYSLVFIFGF VGNMLVIIIL IGCKKLKSMT DIYLLNLAIS
110 120 130 140 150
DLLFLLTLPF WAHYAANEWV FGNIMCKVFT GLYHIGYFGG IFFIILLTID
160 170 180 190 200
RYLAIVHAVF ALKARTVTFG VITSVVTWVV AVFASLPGII FTKSKQDDHH
210 220 230 240 250
YTCGPYFTQL WKNFQTIMRN ILSLILPLLV MVICYSGILH TLFRCRNEKK
260 270 280 290 300
RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQESLGMSNC VIDKHLDQAM
310 320 330 340 350
QVTETLGMTH CCINPVIYAF VGEKFRRYLS IFFRKHIAKR LCKQCPVFYR
360 370
ETADRVSSTF TPSTGEQEVS VGL
Length:373
Mass (Da):42,783
Last modified:May 24, 2005 - v1
Checksum:iFA012C10F4C9325A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138803 mRNA. Translation: AAI38804.1.
BC138804 mRNA. Translation: AAI38805.1.
AK046579 mRNA. Translation: BAC32793.1.
AK138599 mRNA. Translation: BAE23710.1.
CH466671 Genomic DNA. Translation: EDL37176.1.
RefSeqiNP_034045.1. NM_009915.2.
XP_006512489.1. XM_006512426.1.
XP_006512491.1. XM_006512428.2.
XP_011241365.1. XM_011243063.1.
XP_011241366.1. XM_011243064.1.
UniGeneiMm.6272.

Genome annotation databases

GeneIDi12772.
KEGGimmu:12772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138803 mRNA. Translation: AAI38804.1.
BC138804 mRNA. Translation: AAI38805.1.
AK046579 mRNA. Translation: BAC32793.1.
AK138599 mRNA. Translation: BAE23710.1.
CH466671 Genomic DNA. Translation: EDL37176.1.
RefSeqiNP_034045.1. NM_009915.2.
XP_006512489.1. XM_006512426.1.
XP_006512491.1. XM_006512428.2.
XP_011241365.1. XM_011243063.1.
XP_011241366.1. XM_011243064.1.
UniGeneiMm.6272.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049909.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12772.
KEGGimmu:12772.

Organism-specific databases

CTDi729230.
MGIiMGI:106185. Ccr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
KOiK04177.
OMAiCPVFYRE.
OrthoDBiEOG091G0B7A.

Miscellaneous databases

ChiTaRSiCcr2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049103.

Family and domain databases

InterProiIPR002237. Chemokine_CCR2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01107. CHEMOKINER2.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ543S8_MOUSE
AccessioniPrimary (citable) accession number: Q543S8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.