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Protein
Submitted name:

Chemokine (C-C motif) receptor 2

Gene

Ccr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-C motif) receptor 2Imported
Gene namesi
Name:Ccr2Imported
ORF Names:mCG_16379Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106185 Ccr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Transmembranei166 – 191HelicalSequence analysisAdd BLAST26
Transmembranei221 – 243HelicalSequence analysisAdd BLAST23
Transmembranei255 – 278HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ543S8

Expressioni

Gene expression databases

BgeeiENSMUSG00000049103
ExpressionAtlasiQ543S8 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ543S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 318G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG106917
KOiK04177
OMAiCPVFYRE
OrthoDBiEOG091G0B7A

Family and domain databases

InterProiView protein in InterPro
IPR002237 Chemokine_CCR2
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01107 CHEMOKINER2
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q543S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDNNMLPQF IHGILSTSHS LFTRSIQELD EGATTPYDYD DGEPCHKTSV
60 70 80 90 100
KQIGAWILPP LYSLVFIFGF VGNMLVIIIL IGCKKLKSMT DIYLLNLAIS
110 120 130 140 150
DLLFLLTLPF WAHYAANEWV FGNIMCKVFT GLYHIGYFGG IFFIILLTID
160 170 180 190 200
RYLAIVHAVF ALKARTVTFG VITSVVTWVV AVFASLPGII FTKSKQDDHH
210 220 230 240 250
YTCGPYFTQL WKNFQTIMRN ILSLILPLLV MVICYSGILH TLFRCRNEKK
260 270 280 290 300
RHRAVRLIFA IMIVYFLFWT PYNIVLFLTT FQESLGMSNC VIDKHLDQAM
310 320 330 340 350
QVTETLGMTH CCINPVIYAF VGEKFRRYLS IFFRKHIAKR LCKQCPVFYR
360 370
ETADRVSSTF TPSTGEQEVS VGL
Length:373
Mass (Da):42,783
Last modified:May 24, 2005 - v1
Checksum:iFA012C10F4C9325A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138803 mRNA Translation: AAI38804.1
BC138804 mRNA Translation: AAI38805.1
AK046579 mRNA Translation: BAC32793.1
AK138599 mRNA Translation: BAE23710.1
CH466671 Genomic DNA Translation: EDL37176.1
RefSeqiNP_034045.1, NM_009915.2
XP_006512491.1, XM_006512428.2
XP_011241365.1, XM_011243063.1
XP_011241366.1, XM_011243064.2
UniGeneiMm.6272

Genome annotation databases

GeneIDi12772
KEGGimmu:12772

Similar proteinsi

Entry informationi

Entry nameiQ543S8_MOUSE
AccessioniPrimary (citable) accession number: Q543S8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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