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Protein

Purine nucleoside phosphorylase

Gene

Pnp

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33PhosphateUniRule annotation1
Binding sitei64PhosphateUniRule annotation1
Binding sitei116Phosphate; via amide nitrogenUniRule annotation1
Binding sitei201Purine nucleosideUniRule annotation1
Binding sitei220PhosphateUniRule annotation1
Binding sitei243Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-74217. Purine salvage.
R-MMU-74259. Purine catabolism.
UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PnpImported
Synonyms:Pnp1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:97365. Pnp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000021871.

Structurei

3D structure databases

SMRiQ543K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 276PNP_UDP_1InterPro annotationAdd BLAST250

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3984. Eukaryota.
COG0005. LUCA.
GeneTreeiENSGT00550000074740.
HOVERGENiHBG002460.
KOiK03783.
OMAiVLISDHI.
OrthoDBiEOG091G0GEE.
TreeFamiTF300049.

Family and domain databases

InterProiView protein in InterPro
IPR000845. Nucleoside_phosphorylase_d.
IPR035994. Nucleoside_phosphorylase_sf.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiView protein in Pfam
PF01048. PNP_UDP_1. 1 hit.
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
PROSITEiView protein in PROSITE
PS01240. PNP_MTAP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q543K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENEFTYEDY ETTAKWLLQH TEYRPQVAVI CGSGLGGLTA HLKEAQIFDY
60 70 80 90 100
NEIPNFPQST VQGHAGRLVF GLLNGRCCVM MQGRFHMYEG YSLSKVTFPV
110 120 130 140 150
RVFHLLGVET LVVTNAAGGL NPNFEVGDIM LIRDHINLPG FCGQNPLRGP
160 170 180 190 200
NDERFGVRFP AMSDAYDRDM RQKAFSAWKQ MGEQRKLQEG TYVMLAGPNF
210 220 230 240 250
ETVAESRLLK MLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVVMDYE
260 270 280
NLEKANHMEV LDAGKAAAQT LERFVSILME SIPLPDRGS
Length:289
Mass (Da):32,263
Last modified:May 24, 2005 - v1
Checksum:iAE7E497B004A1116
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136376 Genomic DNA. No translation available.
AK049817 mRNA. Translation: BAC33932.1.
AK153451 mRNA. Translation: BAE32005.1.
CT010254 mRNA. Translation: CAJ18462.1.
RefSeqiNP_038660.1. NM_013632.4.
UniGeneiMm.17932.

Genome annotation databases

EnsembliENSMUST00000048615; ENSMUSP00000043926; ENSMUSG00000021871.
ENSMUST00000178092; ENSMUSP00000136557; ENSMUSG00000021871.
GeneIDi18950.
KEGGimmu:18950.
UCSCiuc007tme.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ543K9_MOUSE
AccessioniPrimary (citable) accession number: Q543K9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: January 31, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported