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Q543C6 (Q543C6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Lhx2 MGI 96785
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity SAAS SAAS001781 RuleBase RU000682.

Sequence similarities

Contains 2 LIM zinc-binding domains. RuleBase RU000350

Contains LIM zinc-binding domains. SAAS SAAS001781

Contains homeobox DNA-binding domain. SAAS SAAS001781

Ontologies

Keywords
   Cellular componentNucleus SAAS SAAS001781 RuleBase RU000682
   DomainHomeobox RuleBase RU000682 SAAS SAAS001781
LIM domain SAAS SAAS001781 RuleBase RU000350
Repeat SAAS SAAS001781
   LigandDNA-binding SAAS SAAS001781 RuleBase RU000682
Metal-binding
Zinc
Gene Ontology (GO)
   Biological_processanatomical structure formation involved in morphogenesis

Inferred from mutant phenotype PubMed 11719201. Source: MGI

axon extension

Inferred from direct assay PubMed 21857657. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 17493606. Source: MGI

brain development

Inferred from mutant phenotype PubMed 14566948PubMed 15295034. Source: MGI

cerebral cortex development

Inferred from mutant phenotype PubMed 19820705. Source: MGI

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 11165475PubMed 14566948. Source: MGI

mesoderm development

Inferred from mutant phenotype PubMed 9247336. Source: MGI

negative regulation of transcription regulatory region DNA binding

Inferred from genetic interaction PubMed 9697309. Source: MGI

nervous system development

Inferred from mutant phenotype PubMed 9247336. Source: MGI

neural tube closure

Inferred from mutant phenotype PubMed 11719201. Source: MGI

neurogenesis

Inferred from direct assay PubMed 18184563. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 15173589. Source: MGI

olfactory bulb development

Inferred from mutant phenotype PubMed 19820705. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 10431247PubMed 19146846. Source: MGI

retina development in camera-type eye

Inferred from genetic interaction PubMed 19146846. Source: MGI

telencephalon development

Inferred from mutant phenotype PubMed 11165475PubMed 11719201PubMed 17493606PubMed 19820705. Source: MGI

telencephalon regionalization

Inferred from mutant phenotype PubMed 11719201. Source: MGI

transcription from RNA polymerase II promoter

Inferred from physical interaction PubMed 17991461. Source: GOC

   Cellular_componentintracellular

Inferred from direct assay PubMed 10482234. Source: MGI

nucleus

Inferred from direct assay PubMed 18076286. Source: MGI

   Molecular_functionRNA polymerase II transcription factor binding transcription factor activity

Inferred from physical interaction PubMed 17991461. Source: MGI

chromatin binding

Inferred from direct assay PubMed 19146846. Source: MGI

protein binding

Inferred from physical interaction PubMed 10431247. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 15173589. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q543C6 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: FE7B4E76454D6A90

FASTA40644,419
        10         20         30         40         50         60 
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA ALCAGCGGKI 

        70         80         90        100        110        120 
SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI YCKEDYYRRF SVQRCARCHL 

       130        140        150        160        170        180 
GISASEMVMR ARDLVYHLNC FTCTTCNKML TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH 

       190        200        210        220        230        240 
FNHADVAAAA AAAAAAKSAG LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY 

       250        260        270        280        290        300 
NAALSCNEND AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA 

       310        320        330        340        350        360 
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA SELSNASLSP 

       370        380        390        400 
SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT TLTNLF 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC35432.1.
Tissue: Eyeball EMBL BAC35432.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK053572 mRNA. Translation: BAC35432.1.
RefSeqNP_034840.1. NM_010710.4.
UniGeneMm.142856.

3D structure databases

ProteinModelPortalQ543C6.
SMRQ543C6. Positions 53-165, 262-337.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ543C6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16870.
KEGGmmu:16870.

Organism-specific databases

CTD9355.
MGIMGI:96785. Lhx2.

Phylogenomic databases

HOVERGENHBG006262.
InParanoidQ543C6.
KOK09373.
OMAHECRSPS.
PhylomeDBQ543C6.

Gene expression databases

ArrayExpressQ543C6.
GenevestigatorQ543C6.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio290834.
SOURCESearch...

Entry information

Entry nameQ543C6_MOUSE
AccessionPrimary (citable) accession number: Q543C6
Entry history
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)