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Q543C6

- Q543C6_MOUSE

UniProt

Q543C6 - Q543C6_MOUSE

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Protein
Submitted name:

Putative uncharacterized protein

Gene

Lhx2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. RNA polymerase II transcription factor binding transcription factor activity Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: MGI
  2. axon extension Source: MGI
  3. axon guidance Source: MGI
  4. brain development Source: MGI
  5. cerebral cortex development Source: MGI
  6. dorsal/ventral pattern formation Source: MGI
  7. mesoderm development Source: MGI
  8. negative regulation of transcription regulatory region DNA binding Source: MGI
  9. nervous system development Source: MGI
  10. neural tube closure Source: MGI
  11. neurogenesis Source: MGI
  12. neuron differentiation Source: MGI
  13. olfactory bulb development Source: MGI
  14. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  15. retina development in camera-type eye Source: MGI
  16. telencephalon development Source: MGI
  17. telencephalon regionalization Source: MGI
  18. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Lhx2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96785. Lhx2.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ543C6.

Expressioni

Gene expression databases

ExpressionAtlasiQ543C6. baseline and differential.
GenevestigatoriQ543C6.

Structurei

3D structure databases

ProteinModelPortaliQ543C6.
SMRiQ543C6. Positions 53-165, 262-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.UniRule annotation
Contains LIM zinc-binding domains.SAAS annotation
Contains homeobox DNA-binding domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation, LIM domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOVERGENiHBG006262.
KOiK09373.
OMAiHECRSPS.
PhylomeDBiQ543C6.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q543C6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFHSLSGPE VHGVIDEMDR RAKSEAPAIS SAIDRGDTET TMPSISSDRA
60 70 80 90 100
ALCAGCGGKI SDRYYLLAVD KQWHMRCLKC CECKLNLESE LTCFSKDGSI
110 120 130 140 150
YCKEDYYRRF SVQRCARCHL GISASEMVMR ARDLVYHLNC FTCTTCNKML
160 170 180 190 200
TTGDHFGMKD SLVYCRLHFE ALLQGEYPAH FNHADVAAAA AAAAAAKSAG
210 220 230 240 250
LGSAGANPLG LPYYNGVGTV QKGRPRKRKS PGPGADLAAY NAALSCNEND
260 270 280 290 300
AEHLDRDQPY PSSQKTKRMR TSFKHHQLRT MKSYFAINHN PDAKDLKQLA
310 320 330 340 350
QKTGLTKRVL QVWFQNARAK FRRNLLRQEN TGVDKTSDAT LQTGTPSGPA
360 370 380 390 400
SELSNASLSP SSTPTTLTDL TSPTLPTVTS VLTSVPGNLE GHEPHSPSQT

TLTNLF
Length:406
Mass (Da):44,419
Last modified:May 24, 2005 - v1
Checksum:iFE7B4E76454D6A90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053572 mRNA. Translation: BAC35432.1.
RefSeqiNP_034840.1. NM_010710.4.
UniGeneiMm.142856.

Genome annotation databases

GeneIDi16870.
KEGGimmu:16870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK053572 mRNA. Translation: BAC35432.1 .
RefSeqi NP_034840.1. NM_010710.4.
UniGenei Mm.142856.

3D structure databases

ProteinModelPortali Q543C6.
SMRi Q543C6. Positions 53-165, 262-337.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q543C6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16870.
KEGGi mmu:16870.

Organism-specific databases

CTDi 9355.
MGIi MGI:96785. Lhx2.

Phylogenomic databases

HOVERGENi HBG006262.
KOi K09373.
OMAi HECRSPS.
PhylomeDBi Q543C6.

Miscellaneous databases

NextBioi 290834.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi Q543C6. baseline and differential.
Genevestigatori Q543C6.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: EyeballImported.

Entry informationi

Entry nameiQ543C6_MOUSE
AccessioniPrimary (citable) accession number: Q543C6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)