Q54318 (HLYC_TREHY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemolysin C

Gene names

Name:

tlyC

Organism

Treponema hyodysenteriae (Serpulina hyodysenteriae)

Taxonomic identifier

159 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Brachyspiraceae › Brachyspira

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
Sequence similarities	Belongs to the UPF0053 family. Contains 2 CBS domains.

Ontologies

Keywords
Biological process	Cytolysis Hemolysis
Domain	CBS domain Repeat
Molecular function	Toxin
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW hemolysis in other organism Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Hemolysin C		PRO_0000088354
Regions
	Domain	52 – 111	60	CBS 1
	Domain	114 – 171	58	CBS 2

Sequences

	Sequence		Length	Mass (Da)
	Q54318 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E56A3D43D8764FDA	FASTA	268	30,764
	10 20 30 40 50 60 MPIKKLISKI VKKKDSDTEK NNYINLSALT EAEREIITNT IELKSKSVRE IMVPRVDVVM 70 80 90 100 110 120 IPMESSYDKV IKAFNRDRNS RIPVYKDGID DIVGVLYVKD LIDAEEKNFS LKKILHKPLF 130 140 150 160 170 180 VPISISLMEL LKNFREKQIH IAMVVDEYGG FSGIVSMEDV LEQIIGDIRD EYDEEDEEIK 190 200 210 220 230 240 SNDDGTYLVD ARTRIDDFNK YEILPPIPDD EADTVGGFLF SYLGRLPKRN EDIEYNGYSF 250 260 TVVGKSGNIV TKIRIEKLKK DNTAKNKD

References

[1]	"Characterization of three putative Serpulina hyodysenteriae hemolysins." Ter Huurne A.A.H.M., Muir S., van Houten M., van der Zeijst B.A.M., Gaastra W., Kusters J.G. Microb. Pathog. 16:269-282(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B204.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73141 Genomic DNA. Translation: CAA51657.1.
PIR	T46749.
3D structure databases
ProteinModelPortal	Q54318.
ModBase	Search...
Protein family/group databases
TCDB	9.A.40.1.1. HlyC/CorC (HCC) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.465.10. 1 hit.
InterPro	IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR000644. Cysta_beta_synth_core. IPR005170. Transptr-assoc_dom. [Graphical view]
Pfam	PF00571. CBS. 2 hits. PF03471. CorC_HlyC. 1 hit. [Graphical view]
SMART	SM00116. CBS. 2 hits. SM01091. CorC_HlyC. 1 hit. [Graphical view]
PROSITE	PS51371. CBS. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HLYC_TREHY

Accession

Primary (citable) accession number: Q54318

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program