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Q54318

- HLYC_BRAHO

UniProt

Q54318 - HLYC_BRAHO

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Protein
Hemolysin C
Gene
tlyC
Organism
Brachyspira hyodysenteriae (Treponema hyodysenteriae)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Protein family/group databases

TCDBi9.A.40.1.1. the hlyc/corc (hcc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin C
Gene namesi
Name:tlyC
OrganismiBrachyspira hyodysenteriae (Treponema hyodysenteriae)
Taxonomic identifieri159 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Hemolysin C
PRO_0000088354Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 11160CBS 1
Add
BLAST
Domaini114 – 17158CBS 2
Add
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54318-1 [UniParc]FASTAAdd to Basket

« Hide

MPIKKLISKI VKKKDSDTEK NNYINLSALT EAEREIITNT IELKSKSVRE    50
IMVPRVDVVM IPMESSYDKV IKAFNRDRNS RIPVYKDGID DIVGVLYVKD 100
LIDAEEKNFS LKKILHKPLF VPISISLMEL LKNFREKQIH IAMVVDEYGG 150
FSGIVSMEDV LEQIIGDIRD EYDEEDEEIK SNDDGTYLVD ARTRIDDFNK 200
YEILPPIPDD EADTVGGFLF SYLGRLPKRN EDIEYNGYSF TVVGKSGNIV 250
TKIRIEKLKK DNTAKNKD 268
Length:268
Mass (Da):30,764
Last modified:November 1, 1996 - v1
Checksum:iE56A3D43D8764FDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73141 Genomic DNA. Translation: CAA51657.1.
PIRiT46749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73141 Genomic DNA. Translation: CAA51657.1 .
PIRi T46749.

3D structure databases

ProteinModelPortali Q54318.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 9.A.40.1.1. the hlyc/corc (hcc) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.465.10. 1 hit.
InterProi IPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view ]
SMARTi SM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view ]
SUPFAMi SSF56176. SSF56176. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of three putative Serpulina hyodysenteriae hemolysins."
    Ter Huurne A.A.H.M., Muir S., van Houten M., van der Zeijst B.A.M., Gaastra W., Kusters J.G.
    Microb. Pathog. 16:269-282(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B204.

Entry informationi

Entry nameiHLYC_BRAHO
AccessioniPrimary (citable) accession number: Q54318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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