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Protein

Hemolysin C

Gene

tlyC

Organism
Brachyspira hyodysenteriae (Treponema hyodysenteriae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Protein family/group databases

TCDBi9.A.40.1.1. the hlyc/corc (hcc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemolysin C
Gene namesi
Name:tlyC
OrganismiBrachyspira hyodysenteriae (Treponema hyodysenteriae)
Taxonomic identifieri159 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBrachyspiraceaeBrachyspira

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Hemolysin CPRO_0000088354Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ54318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 11160CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 17158CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q54318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKKLISKI VKKKDSDTEK NNYINLSALT EAEREIITNT IELKSKSVRE
60 70 80 90 100
IMVPRVDVVM IPMESSYDKV IKAFNRDRNS RIPVYKDGID DIVGVLYVKD
110 120 130 140 150
LIDAEEKNFS LKKILHKPLF VPISISLMEL LKNFREKQIH IAMVVDEYGG
160 170 180 190 200
FSGIVSMEDV LEQIIGDIRD EYDEEDEEIK SNDDGTYLVD ARTRIDDFNK
210 220 230 240 250
YEILPPIPDD EADTVGGFLF SYLGRLPKRN EDIEYNGYSF TVVGKSGNIV
260
TKIRIEKLKK DNTAKNKD
Length:268
Mass (Da):30,764
Last modified:November 1, 1996 - v1
Checksum:iE56A3D43D8764FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73141 Genomic DNA. Translation: CAA51657.1.
PIRiT46749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73141 Genomic DNA. Translation: CAA51657.1.
PIRiT46749.

3D structure databases

ProteinModelPortaliQ54318.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi9.A.40.1.1. the hlyc/corc (hcc) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of three putative Serpulina hyodysenteriae hemolysins."
    Ter Huurne A.A.H.M., Muir S., van Houten M., van der Zeijst B.A.M., Gaastra W., Kusters J.G.
    Microb. Pathog. 16:269-282(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B204.

Entry informationi

Entry nameiHLYC_BRAHO
AccessioniPrimary (citable) accession number: Q54318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.