Q54316 (HLYB_TREHY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemolysin B

Gene names

Name:

tlyB

Organism

Treponema hyodysenteriae (Serpulina hyodysenteriae)

Taxonomic identifier

159 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Brachyspiraceae › Brachyspira

Protein attributes

Sequence length	828 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
Sequence similarities	Belongs to the clpA/clpB family. ClpC subfamily. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	Cytolysis Hemolysis
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone Toxin
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW hemolysis in other organism Inferred from electronic annotation. Source: UniProtKB-KW protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 828	828	Hemolysin B		PRO_0000191229
Regions
	Repeat	20 – 51	32	1
	Repeat	96 – 127	32	2
	Domain	426 – 461	36	UVR
	Nucleotide binding	217 – 224	8	ATP Potential
	Nucleotide binding	554 – 561	8	ATP Potential
	Region	20 – 127	108	2 X 32 AA approximate repeats
	Region	172 – 419	248	I
	Region	480 – 671	192	II
	Compositional bias	662 – 665	4	Poly-Ile

Sequences

	Sequence		Length	Mass (Da)
	Q54316 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2F7E1183000438C2	FASTA	828	93,311
	10 20 30 40 50 60 MFQFHLTSKA KKVIELYAQE EAKRLNHDMV TPEHILLGLL YESEALATRV LMRLKIDLDR 70 80 90 100 110 120 LKLELESAMV KSSTTKVFGT LPTAPRVQKL ISRSAEEARA LSHNYIGTEH LLLGLLREES 130 140 150 160 170 180 GTAYNVLTSM GLELTILRQE ILKMLGVAGS NISSMEQTSQ EDNVKKVKTP TLDQFARDLT 190 200 210 220 230 240 KMARDKALDR VIGRENEVMR VVQILSRRKK NNPILLGEPG VGKTAIVEGL AEKIVAADVP 250 260 270 280 290 300 DILLKKRVLT LDLSSVVAGT KYRGEFEERI KNIVLEIKKA SNIIIFIDEL HTLIGAGGAE 310 320 330 340 350 360 GALDAANMLK PALSRGEIQC IGATTINEYK KYIEKDGALV RRFQPINVEE PSIEDTIEIL 370 380 390 400 410 420 NGIKGKYEEH HKVKYTDEAI NAAAVLSKRY IFERHLPDKA IDLIDEAGSR ARLLNMTRPQ 430 440 450 460 470 480 EFKDLEKKIE ELNQQKKRVV ESQNFEDAAK IRDEITSLQE ELSKKEEKCR EEREKIETFI 490 500 510 520 530 540 EEDDIRHVIS EITNIPIKRL LNSESKRLIG MEEELHQKVV GQKEAISSIS KAIRRSRAGL 550 560 570 580 590 600 KTSKRPLGSF IFLGPTGVGK TALAKVLSEF MFGDSDALIR IDMSEFMEKF AVSRLIGAPP 610 620 630 640 650 660 GYVGYEEGGG LTEKVRRKPY SLILFDEIEK AHPDVTNILL QVLEEGQLTD NFGRKVDFSN 670 680 690 700 710 720 TIIIITSNLG ARDIVKGSSL GFNAVGSEKD ANDIKNFALE ELKQNFNPEF LNRIDDIIVF 730 740 750 760 770 780 HTLSKEDLKD IINIMLKELN EAIKERNIVI NLSEEAKNYI IDKGFDKKYG ARSLRRAIQK 790 800 810 820 EIEDYVSTEI LFGNIEDGDT INVDRNDGSL IFSYDKSVKT ENKELSKS

References

[1]	"Characterization of three putative Serpulina hyodysenteriae hemolysins." Ter Huurne A.A.H.M., Muir S., van Houten M., van der Zeijst B.A.M., Gaastra W., Kusters J.G. Microb. Pathog. 16:269-282(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B204.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X73140 Genomic DNA. Translation: CAA51655.1.
3D structure databases
ProteinModelPortal	Q54316.
SMR	Q54316. Positions 172-352.
ModBase	Search...
Proteomic databases
PRIDE	Q54316.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1780.10. 1 hit. 4.10.860.10. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR003959. ATPase_AAA_core. IPR018368. Chaperonin_ClpA/B_CS. IPR001270. Chaprnin_ClpA/B. IPR019489. Clp_ATPase_C. IPR004176. Clp_N. IPR023150. Dbl_Clp-N. IPR001943. UVR_dom. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF07724. AAA_2. 1 hit. PF02861. Clp_N. 2 hits. PF10431. ClpB_D2-small. 1 hit. PF02151. UVR. 1 hit. [Graphical view]
PRINTS	PR00300. CLPPROTEASEA.
SMART	SM00382. AAA. 2 hits. SM01086. ClpB_D2-small. 1 hit. [Graphical view]
PROSITE	PS00870. CLPAB_1. 1 hit. PS00871. CLPAB_2. 1 hit. PS50151. UVR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HLYB_TREHY

Accession

Primary (citable) accession number: Q54316

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program