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Protein
Submitted name:

Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_a

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Epidermal growth factor-containing fibulin-like extracellular matrix protein 2, isoform CRA_aImported
Gene namesi
Name:Efemp2Imported
ORF Names:mCG_11764Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1891209 Efemp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501430955528 – 443Sequence analysisAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi207 ↔ 217PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRIDEiQ542X5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024909
ExpressionAtlasiQ542X5 baseline and differential

Structurei

3D structure databases

SMRiQ542X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 163EGF-likeInterPro annotationAdd BLAST41
Domaini164 – 202EGF-likeInterPro annotationAdd BLAST39
Domaini203 – 238EGF-likeInterPro annotationAdd BLAST36
Domaini243 – 282EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IR6U Eukaryota
ENOG410ZNNG LUCA
HOVERGENiHBG051560
KOiK19866

Family and domain databases

InterProiView protein in InterPro
IPR026823 cEGF
IPR026824 Efemp2
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037287 Fibulin_3/4/5
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44074 PTHR44074, 1 hit
PTHR44074:SF3 PTHR44074:SF3, 1 hit
PfamiView protein in Pfam
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Q542X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ
60 70 80 90 100
HCRDVNECLT IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA
110 120 130 140 150
AHAQQPNPCP QGYEPDEQES CVDVDECTQA LHDCRPSQDC HNLPGSYQCT
160 170 180 190 200
CPDGYRKIGP ECVDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS
210 220 230 240 250
CVDVNECDMG APCEQRCFNS YGTFLCRCNQ GYELHRDGFS CSDIDECGYS
260 270 280 290 300
SYLCQYRCVN EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC
310 320 330 340 350
VNFHGGYRCV DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI
360 370 380 390 400
TSERSVPADV FQIQATSVYP GAYNAFQIRS GNTQGDFYIR QINNVSAMLV
410 420 430 440
LARPVTGPRE YVLDLEMVTM NSLMSYRASS VLRLTVFVGA YTF
Length:443
Mass (Da):49,425
Last modified:May 24, 2005 - v1
Checksum:i4969C0328A23DD88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075585 mRNA Translation: BAC35838.1
CH466612 Genomic DNA Translation: EDL33138.1
CH466612 Genomic DNA Translation: EDL33139.1
RefSeqiNP_001157824.1, NM_001164352.1
NP_067449.3, NM_021474.3
XP_006531871.1, XM_006531808.1
UniGeneiMm.276367

Genome annotation databases

GeneIDi58859
KEGGimmu:58859

Similar proteinsi

Entry informationi

Entry nameiQ542X5_MOUSE
AccessioniPrimary (citable) accession number: Q542X5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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