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Protein

Muscarinic acetylcholine receptor

Gene

Chrm3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorCurated, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptorCurated
Gene namesi
Name:Chrm30 Publication
ORF Names:mCG_522880 Publication
OrganismiMus musculus (Mouse)0 Publication
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88398. Chrm3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 92HelicalCuratedAdd BLAST29
Transmembranei104 – 130HelicalCuratedAdd BLAST27
Transmembranei142 – 163HelicalCuratedAdd BLAST22
Transmembranei184 – 209HelicalCuratedAdd BLAST26
Transmembranei229 – 251HelicalCuratedAdd BLAST23
Transmembranei488 – 508HelicalCuratedAdd BLAST21
Transmembranei528 – 546HelicalCuratedAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membraneCurated, Membrane, Postsynaptic cell membraneCurated, Synapse

Expressioni

Gene expression databases

BgeeiENSMUSG00000046159.

Structurei

3D structure databases

SMRiQ542R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 543G_PROTEIN_RECEP_F1_2ImportedAdd BLAST460

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helixCurated

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
HOVERGENiHBG105720.
KOiK04131.
OMAiCQCDKRK.
OrthoDBiEOG091G06VI.

Family and domain databases

CDDicd15299. 7tmA_mAChR_M3. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001183. Musac_Ach_M3_rcpt.
IPR000995. Musac_Ach_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00540. MUSCRINICM3R.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q542R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVSQLDSY NISQTSGNFS
60 70 80 90 100
SNDTSSDPLG GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT
110 120 130 140 150
VNNYFLLSLA CADLIIGVIS MNLFTTYIIM NRWALGNLAC DLWLSIDYVA
160 170 180 190 200
SNASVMNLLV ISFDRYFSIT RPLTYRAKRT TKRAGVMIGL AWVISFVLWA
210 220 230 240 250
PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY MPVTIMTILY
260 270 280 290 300
WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGTK
310 320 330 340 350
RSSRRKYGGC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS
360 370 380 390 400
SDEEDIGSET RAIYSIVLKL PGHSTILNST KLPSSDNLQV PDKDLGTMDV
410 420 430 440 450
ERNAHKLQAQ KSMDDRDNCQ KDFSKLPIQL ESAVDTAKTS DTNSSVDKTT
460 470 480 490 500
AALPLSFKEA TLAKRFALKT RSQITKRKRM SLIKEKKAAQ TLSAILLAFI
510 520 530 540 550
ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP VCYALCNKTF
560 570 580
RTTFKMLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL
Length:589
Mass (Da):66,212
Last modified:May 24, 2005 - v1
Checksum:iAB782149EBEE7804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129892 mRNA. Translation: AAI29893.1.
BC129893 mRNA. Translation: AAI29894.1.
AK080950 mRNA. Translation: BAC38088.1.
CH466588 Genomic DNA. Translation: EDL32297.1.
RefSeqiNP_150372.1. NM_033269.4.
XP_006516531.1. XM_006516468.3.
UniGeneiMm.342315.

Genome annotation databases

GeneIDi12671.
KEGGimmu:12671.

Similar proteinsi

Entry informationi

Entry nameiQ542R4_MOUSE
AccessioniPrimary (citable) accession number: Q542R4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 22, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)