Chrm3

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.UniRule annotation

GO - Molecular functionⁱ

acetylcholine binding Source: Ensembl
drug binding Source: Ensembl
G-protein coupled acetylcholine receptor activity Source: UniProtKB-UniRule

Complete GO annotation...

GO - Biological processⁱ

positive regulation of smooth muscle contraction Source: Ensembl
regulation of vascular smooth muscle contraction Source: Ensembl
saliva secretion Source: InterPro
smooth muscle contraction Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	G-protein coupled receptorUniRule annotation, Receptor, Transducer

Molecular function

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptorUniRule annotation
Gene namesⁱ	Name:Chrm3Imported ORF Names:mCG_52288Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:88398. Chrm3.

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	64 – 92	HelicalUniRule annotationAdd BLAST	29
Transmembraneⁱ	104 – 130	HelicalUniRule annotationAdd BLAST	27
Transmembraneⁱ	142 – 163	HelicalUniRule annotationAdd BLAST	22
Transmembraneⁱ	184 – 209	HelicalUniRule annotationAdd BLAST	26
Transmembraneⁱ	229 – 251	HelicalUniRule annotationAdd BLAST	23
Transmembraneⁱ	488 – 508	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	528 – 546	HelicalUniRule annotationAdd BLAST	19

GO - Cellular componentⁱ

asymmetric synapse Source: Ensembl
axon terminus Source: Ensembl
cell junction Source: UniProtKB-UniRule
dendrite Source: Ensembl
integral component of plasma membrane Source: Ensembl
postsynaptic membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell junction, Cell membraneUniRule annotation, Membrane, Postsynaptic cell membraneUniRule annotation, Synapse

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000046159.
ExpressionAtlasⁱ	Q542R4. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q542R4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	84 – 543	G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST		460

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG4220. Eukaryota. ENOG410YCQR. LUCA.
HOVERGENⁱ	HBG105720.
KEGG Orthology (KO) More...KOⁱ	K04131.
OMAⁱ	CQCDKRK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001183. Musac_Ach_M3_rcpt. IPR000995. Musac_Ach_rcpt.
PANTHERⁱ	PTHR24249:SF357. PTHR24249:SF357. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00540. MUSCRINICM3R.
SMARTⁱ	View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q542R4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVSQLDSY NISQTSGNFS 
        60         70         80         90        100
SNDTSSDPLG GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT 
       110        120        130        140        150
VNNYFLLSLA CADLIIGVIS MNLFTTYIIM NRWALGNLAC DLWLSIDYVA 
       160        170        180        190        200
SNASVMNLLV ISFDRYFSIT RPLTYRAKRT TKRAGVMIGL AWVISFVLWA 
       210        220        230        240        250
PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY MPVTIMTILY 
       260        270        280        290        300
WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGTK 
       310        320        330        340        350
RSSRRKYGGC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS 
       360        370        380        390        400
SDEEDIGSET RAIYSIVLKL PGHSTILNST KLPSSDNLQV PDKDLGTMDV 
       410        420        430        440        450
ERNAHKLQAQ KSMDDRDNCQ KDFSKLPIQL ESAVDTAKTS DTNSSVDKTT 
       460        470        480        490        500
AALPLSFKEA TLAKRFALKT RSQITKRKRM SLIKEKKAAQ TLSAILLAFI 
       510        520        530        540        550
ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP VCYALCNKTF 
       560        570        580 
RTTFKMLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL

Length:589

Mass (Da):66,212

Last modified:May 24, 2005 - v1

Checksum:ⁱAB782149EBEE7804

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC129892 mRNA. Translation: AAI29893.1. BC129893 mRNA. Translation: AAI29894.1. AK080950 mRNA. Translation: BAC38088.1. CH466588 Genomic DNA. Translation: EDL32297.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_150372.1. NM_033269.4. XP_006516531.1. XM_006516468.3.
UniGeneⁱ	Mm.342315.

Genome annotation databases

GeneIDⁱ	12671.
KEGGⁱ	mmu:12671.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC129892 mRNA. Translation: AAI29893.1. BC129893 mRNA. Translation: AAI29894.1. AK080950 mRNA. Translation: BAC38088.1. CH466588 Genomic DNA. Translation: EDL32297.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_150372.1. NM_033269.4. XP_006516531.1. XM_006516468.3.
UniGeneⁱ	Mm.342315.

3D structure databases

SMRⁱ	Q542R4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	12671.
KEGGⁱ	mmu:12671.

Organism-specific databases

CTDⁱ	1131.
MGIⁱ	MGI:88398. Chrm3.

Phylogenomic databases

eggNOGⁱ	KOG4220. Eukaryota. ENOG410YCQR. LUCA.
HOVERGENⁱ	HBG105720.
KEGG Orthology (KO) More...KOⁱ	K04131.
OMAⁱ	CQCDKRK.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000046159.
ExpressionAtlasⁱ	Q542R4. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001183. Musac_Ach_M3_rcpt. IPR000995. Musac_Ach_rcpt.
PANTHERⁱ	PTHR24249:SF357. PTHR24249:SF357. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001. 7tm_1. 1 hit.
PRINTSⁱ	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00540. MUSCRINICM3R.
SMARTⁱ	View protein in SMART SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q542R4_MOUSE
Accessionⁱ	Q542R4Primary (citable) accession number: Q542R4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 24, 2005
	Last sequence update:	May 24, 2005
	Last modified:	July 5, 2017
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - Q542R4 (Q542R4_MOUSE)

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Muscarinic acetylcholine receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ