ID Q542P9_MOUSE Unreviewed; 468 AA. AC Q542P9; DT 24-MAY-2005, integrated into UniProtKB/TrEMBL. DT 24-MAY-2005, sequence version 1. DT 27-MAR-2024, entry version 173. DE RecName: Full=Peroxisome proliferator-activated receptor alpha {ECO:0000256|ARBA:ARBA00019236}; DE AltName: Full=Nuclear receptor subfamily 1 group C member 1 {ECO:0000256|ARBA:ARBA00032723}; GN Name=Ppara {ECO:0000313|MGI:MGI:104740}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC38303.1}; RN [1] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAE28893.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE28893.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAE28893.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [9] {ECO:0000313|EMBL:BAC38303.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38303.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38303.1}, Liver RC {ECO:0000313|EMBL:BAE28893.1}, and Urinary bladder RC {ECO:0000313|EMBL:BAC29149.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- FUNCTION: Ligand-activated transcription factor. Key regulator of lipid CC metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- CC glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by CC oleylethanolamide, a naturally occurring lipid that regulates satiety. CC Receptor for peroxisome proliferators such as hypolipidemic drugs and CC fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty CC acids. Functions as a transcription activator for the ACOX1 and P450 CC genes. Transactivation activity requires heterodimerization with RXRA CC and is antagonized by NR2C2. May be required for the propagation of CC clock information to metabolic pathways regulated by PER2. CC {ECO:0000256|ARBA:ARBA00043860}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|RuleBase:RU004334}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 CC subfamily. {ECO:0000256|ARBA:ARBA00008092}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK035676; BAC29149.1; -; mRNA. DR EMBL; AK081709; BAC38303.1; -; mRNA. DR EMBL; AK149460; BAE28893.1; -; mRNA. DR RefSeq; NP_001106889.1; NM_001113418.1. DR RefSeq; NP_035274.2; NM_011144.6. DR RefSeq; XP_006520682.1; XM_006520619.1. DR RefSeq; XP_006520683.1; XM_006520620.3. DR RefSeq; XP_006520684.1; XM_006520621.3. DR RefSeq; XP_006520685.1; XM_006520622.3. DR RefSeq; XP_006520686.1; XM_006520623.3. DR RefSeq; XP_011243818.1; XM_011245516.2. DR RefSeq; XP_011243819.1; XM_011245517.2. DR RefSeq; XP_011243821.1; XM_011245519.2. DR AlphaFoldDB; Q542P9; -. DR SMR; Q542P9; -. DR MaxQB; Q542P9; -. DR Antibodypedia; 13823; 930 antibodies from 39 providers. DR DNASU; 19013; -. DR GeneID; 19013; -. DR KEGG; mmu:19013; -. DR AGR; MGI:104740; -. DR CTD; 5465; -. DR MGI; MGI:104740; Ppara. DR VEuPathDB; HostDB:ENSMUSG00000022383; -. DR HOGENOM; CLU_007368_4_1_1; -. DR OMA; ANNNPPF; -. DR OrthoDB; 3475284at2759; -. DR BioGRID-ORCS; 19013; 5 hits in 82 CRISPR screens. DR ChiTaRS; Ppara; mouse. DR ExpressionAtlas; Q542P9; baseline and differential. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0008289; F:lipid binding; IEA:Ensembl. DR GO; GO:0097371; F:MDM2/MDM4 family protein binding; IEA:Ensembl. DR GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IEA:Ensembl. DR GO; GO:0051525; F:NFAT protein binding; IEA:Ensembl. DR GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl. DR GO; GO:0003707; F:nuclear steroid receptor activity; IEA:Ensembl. DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl. DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl. DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl. DR GO; GO:0001223; F:transcription coactivator binding; IEA:Ensembl. DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:Ensembl. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0035095; P:behavioral response to nicotine; IEA:Ensembl. DR GO; GO:0071332; P:cellular response to fructose stimulus; IEA:Ensembl. DR GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl. DR GO; GO:0007507; P:heart development; IEA:Ensembl. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:Ensembl. DR GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl. DR GO; GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; IEA:Ensembl. DR GO; GO:0010887; P:negative regulation of cholesterol storage; IEA:Ensembl. DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl. DR GO; GO:0045820; P:negative regulation of glycolytic process; IEA:Ensembl. DR GO; GO:1903944; P:negative regulation of hepatocyte apoptotic process; IEA:Ensembl. DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl. DR GO; GO:1903038; P:negative regulation of leukocyte cell-cell adhesion; IEA:Ensembl. DR GO; GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IEA:Ensembl. DR GO; GO:1902894; P:negative regulation of miRNA transcription; IEA:Ensembl. DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl. DR GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; IEA:Ensembl. DR GO; GO:0010891; P:negative regulation of sequestering of triglyceride; IEA:Ensembl. DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl. DR GO; GO:0046209; P:nitric oxide metabolic process; IEA:Ensembl. DR GO; GO:2001171; P:positive regulation of ATP biosynthetic process; IEA:Ensembl. DR GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Ensembl. DR GO; GO:1904189; P:positive regulation of transformation of host cell by virus; IEA:Ensembl. DR GO; GO:0019217; P:regulation of fatty acid metabolic process; IEA:Ensembl. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl. DR GO; GO:0032868; P:response to insulin; IEA:Ensembl. DR GO; GO:0007584; P:response to nutrient; IEA:Ensembl. DR CDD; cd06965; NR_DBD_Ppar; 1. DR CDD; cd06932; NR_LBD_PPAR; 1. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1. DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1. DR InterPro; IPR003074; 1Cnucl_rcpt. DR InterPro; IPR035500; NHR-like_dom_sf. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd. DR InterPro; IPR001723; Nuclear_hrmn_rcpt. DR InterPro; IPR003076; PPAR-alpha. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1. DR PANTHER; PTHR24082:SF197; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA; 1. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR01288; PROXISOMEPAR. DR PRINTS; PR01289; PROXISOMPAAR. DR PRINTS; PR00398; STRDHORMONER. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1. DR PROSITE; PS51843; NR_LBD; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 2: Evidence at transcript level; KW Activator {ECO:0000256|ARBA:ARBA00023159}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|RuleBase:RU004334}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, KW ECO:0000256|RuleBase:RU004334}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|RuleBase:RU004334}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}. FT DOMAIN 99..173 FT /note="Nuclear receptor" FT /evidence="ECO:0000259|PROSITE:PS51030" FT DOMAIN 239..466 FT /note="NR LBD" FT /evidence="ECO:0000259|PROSITE:PS51843" SQ SEQUENCE 468 AA; 52347 MW; 2930A5191C610B6B CRC64; MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS IGEESSGSFG FADYQYLGSC PGSEGSVITD TLSPASSPSS VSCPVIPAST DESPGSALNI ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDLKDSET ADLKSLGKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV IHDMETLCMA EKTLVAKMVA NGVEDKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL QEGIVHVLKL HLQSNHPDDT FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT ESDAALHPLL QEIYRDMY //